The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia

Biochemical and Biophysical Research Communications

Volumn 273, Issue 1, 2000, Pages 231-238

  Maltepe, Emin ^a   Keith, Brian ^b   Arsham, Andrew M ^b   Brorson, James R ^b   Simon, M Celeste ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Angiogenesis; ARNT2; Gene expression; HIF 1; Hypoxia; Neuron; VEGF

Indexed keywords

HELIX LOOP HELIX PROTEIN; NUCLEAR PROTEIN; VASCULOTROPIN;

ARTICLE; CANCER GROWTH; CELL TYPE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; LIVER CELL; LIVER CELL CARCINOMA; NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERATOCARCINOMA; TUMOR VASCULARIZATION;

EID: 0034709652     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2928     Document Type: Article

References (40)

1. Semenza G. L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15:1999;551-578.
2. Bunn H. F., Poyton R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76:1996;839-885.
3. Tian H., McKnight S. L., Russell D. W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11:1997;72-82.
4. Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y. Z., Pray-Grant M., Perdew G. H., Bradfield C. A. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272:1997;8581-8593.
5. Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. USA. 94:1997;4273-4278.
6. Flamme I., Frohlich T., von Reutern M., Kappel A., Damert A., Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech. Dev. 63:1997;51-60.
7. Gu Y. Z., Moran S. M., Hogenesch J. B., Wartman L., Bradfield C. A. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 7:1998;205-213.
8. Hirose K., Morita M., Ema M., Mimura J., Hamada H., Fujii H., Saijo Y., Gotoh O., Sogawa K., Fujii-Kuriyama Y. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the Aryl hydrocarbon receptor nuclear translocator (Arnt). Mol. Cell. Biol. 16:1996;1706-1713.
9. Drutel G., Heron A., Kathmann M., Gros C., Mace S., Plotkine M., Schartz J., Arrang J. ARNT2, a transcription factor for brain neuron survival? Eur. J. Neurosci. 11:1999;1545-1553.
10. Ikeda M., Nomura M. cDNA cloning and tissue-specific expression of a novel basic helix-loop- helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem. Biophys. Res. Commun. 233:1997;258-264.
11. Jain S., Maltepe E., Lu M. M., Simon C., Bradfield C. A. Expression of ARNT, ARNT2, HIF1alpha, HIF2alpha and Ah receptor mRNAs in the developing mouse. Mech. Dev. 73:1998;117-123.
12. Wiesener M., Turley H., Allen W., William C., Eckardt K., Talks K., Wood S., Gatter K., Harris A., Pugh C., Ratcliffe P., Maxwell P. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood. 92:1998;2260-2268.
13. Ryan H. E., Lo J., Johnson R. S. HIF-1a is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015.
14. Iyer N. V., Kotch L. E., Agani F., Leung S. W., Laughner E., Wenger R. H., Gassmann M., Gearhart J. D., Lawler A. M., Yu A. Y., Semenza G. L. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12:1998;149-162.
15. Tian H., Hammer R. E., Matsumoto A. M., Russell D. W., McKnight S. L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12:1998;3320-3324.
16. Maltepe E., Schmidt J. V., Baunoch D., Bradfield C. A., Simon M. C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 386:1997;403-407.
17. Kozak K. R., Abbott B., Hankinson O. ARNT-deficient mice and placental differentiation. Dev. Biol. 191:1997;297-305.
18. Goldberg M. P., Choi D. W. Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13:1993;3510-3524.
19. Brorson J. R., Zhang H. Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons. J. Neurochem. 69:1997;1882-1889.
20. Miller A. G., Israel D., Whitlock J. P. Jr. Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity. J. Biol. Chem. 258:1983;3523-3527.
21. Kuo C. T., Morrisey E. E., Anandappa R., Sigrist K., Lu M. M., Parmacek M. S., Soudais C., Leiden J. M. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11:1997;1048-1060.
22. Andrews N., Faller D. Rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:1991;2499.
23. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K. S., Powell-Braxton L., Hillan K. J., Moore M. W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 380:1996;439-442.
24. Morrisey E. E., Ip H. S., Tang Z., Lu M. M., Parmacek M. S. GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev. Biol. 183:1997;21-36.
25. Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 359:1992;843-845.
26. Maxwell P. H., Dachs G. U., Gleadle J. M., Nicholls L. G., Harris A. L., Stratford I. J., Hankinson O., Pugh C. W., Ratcliffe P. J. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA. 94:1997;8104-8109.
27. 2+ homeostasis in hippocampal neurons. J. Neurochem. 68:1997;95-105.
28. Brewer G. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and denatate gyrus. J. Neurosci. Res. 42:1995;674-683.
29. Brewer G., Torricelli J., Evege E., Price P. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35:1993;556-576.
30. Ruscher K., Isaev N., Trendelenburg G., Weih M., Iurato L., Meisel A., Dirnagl U. Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons. Neurosci. Lett. 254:1998;117-120.
31. Seidel S. D., Denison M. S. Differential gene expression in wild-type and arnt-defective mouse hepatoma (Hepa1c1c7) cells. Toxicol. Sci. 52:1999;217-225.
32. Hogenesch J. B., Gu Y. Z., Jain S., Bradfield C. A. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. USA. 95:1998;5474-5479.
33. Samoto K., Ikezaki K., Ono M., Shono T., Kohno K., Kuwano M., Fukui M. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res. 55:1995;1189-1193.
34. Hatva E., Kaipainen A., Mentula P., Jaaskelainen J., Paetau A., Haltia M., Alitalo K. Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am. J. Pathol. 146:1995;368-378.
35. Berkman R., Merrill J., Reinhold W., Monacci W., Saxena A., Clark W., Robertson J., Ali I., Oldfield E. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest. 91:1993;153-159.
36. Carmeliet P., Dor Y., Herbert J. M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C. J., Ratcliffe P., Moons L., Jain R. K., Collen D., Keshet E. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:1998;485-490.
37. An W. G., Kanekal M., Simon M. C., Maltepe E., Blagosklonny M. V., Neckers L. M. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature. 392:1998;405-408.
38. Ravi R., Mookerjee B., Bhujwalla Z. M., Sutter C. H., Artemov D., Zeng Q., Dillehay L. E., Madan A., Semenza G. L., Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:2000;34-44.
39. Michaud J. L., DeRossi C., May N. R., Holdener B. C., Fan C. ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mech. Dev. 90:2000;253-261.
40. Michaud J. L., Rosenquist T., May N. R., Fan C. M. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1 [In Process Citation]. Genes Dev. 12:1998;3264-3275.