Hypoxic cervical cancers with low apoptotic index are highly aggressive

Cancer Research

Volumn 59, Issue 18, 1999, Pages 4525-4528

  Höckel, Michael ^a,c   Schlenger, Karlheinz ^b   Höckel, Susanne ^b   Vaupel, Peter ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CARCINOGENESIS; FEMALE; FOLLOW UP; HUMAN; HYPOXIA; LYMPH FLOW; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TISSUE OXYGENATION; UTERINE CERVIX CANCER;

EID: 0037480606     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., and Scott, O. C. A. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol., 26: 638-648, 1953.
2. Gatenby, R. A., Kessler, H. B., Rosenblum, J. S., Coia, L. R., Moldofsky, P. J., Hartz, W. H., and Broder, G. J. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 14: 831-838, 1988.
3. 2 tension measurements. Cancer Res., 51: 6098-6102, 1991.
4. Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., and Vaupel, P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res., 56: 4509-4515, 1996.
5. Höckel, M., Schlenger, K., Höckel, S., Aral, B., Schäffer, U., and Vaupel, P. Tumor hypoxia in pelvic recurrences of cervical cancer. Int. J. Cancer, 79: 365-369, 1998.
6. Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989.
7. Brizel, D. W., Scully, S. P., Harrelson, J. M., Layfield, L. J., Bean, J. M., Prosnitz, L. R., and Dewhirst, M. W. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res., 56: 941-943, 1996.
8. Nordsmark, M., and Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol., 41: 31-39, 1996.
9. Young, S. D., Marshall, R. S., and Hill, R. P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc. Natl. Acad. Sci. USA, 85: 9533-9537, 1988.
10. Reynolds, T. Y., Rockwell, S., and Glazer, P. M. Genetic instability by the tumor microenvironment. Cancer Res., 56: 5754-5757, 1996.
11. Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., and Ratcliffe P. J. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA, 94: 8104-8109, 1997.
12. Graham, C. H., Forsdike, J., Fitzgerald. C. J., and MacDonald-Goodfellow, S. Hypoxia-mediated stimulation of carcinoma cell invasiveness via up-regulation of urokinase receptor expression. Int. J. Cancer, 80: 617-623, 1999.
13. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. K., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature (Lond.), 379: 88-91, 1996.
14. Kim, C. Y., Tsai, M. H., Osmanian, C., Graeber, T. G., Lee, J. E., Giffard, R. G., DiPaolo, J. A., Peehl, D. M., and Giaccia, A. J. Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res., 57: 4200-4204, 1997.
15. Gerdes, J. Becker, M. H., Key, G., and Cattoretti, G. Immunohistological detection of tumor growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J. Pathol., 168: 85-86, 1992.
16. Levine, E. L., Renehan, A., Gossiel R., Davidson, S. E., Roberts, S. A., Chadwick, G., Wilks, D. P., Potten, C. S., Hendry, F. H., and Hunter, R. D. Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. Radiother. Oncol., 37: 1-9, 1995.
17. Levine, E. L., Davidson, S. E., Roberts, S. A., Chadwick, C. A., Potten, C. S., and West, G. M. Apoptosis as predictor of response to radiotherapy in cervical carcinoma. Lancet, 344: 472, 1994.
18. Altman, P. L., and Dittmer, D. S., (eds.), Biology Data Book, Vol. III, Ed. 2, pp. 1942-1947. Federation of American Societies for Experimental Biology, Bethesda, MD: 1974.
19. D'Amico, A. V., and McKenna, W. G. Apoptosis and a reinvestigation of the biologic basis for cancer therapy. Radiother. Oncol., 33: 3-10, 1994.
20. Höckel, M. Uterine cervix. In: B. U. Sevin, P. G. Knapstein, and O. R. Köchli (eds.), Multimodality Therapy in Gynecologic Oncology, pp. 94-96. Stuttgart, Germany: Thieme, 1996.