Secretory pathway of trypanosomatid parasites

Microbiology and Molecular Biology Reviews

Volumn 66, Issue 1, 2002, Pages 122-154

  McConville, Malcolm J ^a   Mullin, Kylie A ^a   Ilgoutz, Steven C ^a   Teasdale, Rohan D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMIASIS; ANIMAL PARASITOSIS; CELL SURFACE; CHAGAS DISEASE; EUKARYOTE EVOLUTION; INFECTION; LEISHMANIA; LEISHMANIASIS; NONHUMAN; PARASITE SURVIVAL; PROTEIN GLYCOSYLATION; PROTEIN TRANSPORT; REVIEW; SECRETION; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; BIOLOGICAL TRANSPORT; LIPID METABOLISM; PROTEIN SORTING SIGNALS; PROTOZOAN PROTEINS; TRYPANOSOMATINA;

ANIMALIA; BOS TAURUS; EUKARYOTA; INSECTA; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 0036198697     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/MMBR.66.1.122-154.2002     Document Type: Review

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154. Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana
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157. A developmentally regulated rab11 homologue in Trypanosoma brucei is involved in recycling processes
158. Isolation and characterization of Leishmania donovani calreticulin gene and its conservation of the RNA binding activity
159. Targeted gene deletion of Leishmania major genes encoding developmental stagespecific leishmanolysin (GP63)
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161. Molecular cloning of p67, a lysosomal membrane glycoprotein from Trypanosoma brucei
162. Processing and transport of a lysosomal membrane glycoprotein is developmentally regulated in African trypanosomes
163. Transport between ER and Golgi
164. Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae
165. Retention of glucose units added by the UDP-Glc: Glycoprotein glucosyltransferase delays exit of glycoproteins from the endoplasmic reticulum
166. Trypanosoma cruzi calreticulin is a lectin that binds monoglucosylated oligosaccharides but not protein moieties of glycoproteins
167. Functional analysis of the trypanosomal AAA protein TbVCP with trans-dominant ATP-hydrolysis mutants
168. Genetics and biochemistry of Leishmania membrane transporters
169. The flagellum and flagellar pocket of trypanosomatids
170. Protein uptake and digestion in bloodstream and culture forms of Trypanosoma brucei
171. Trypanosoma cruzi: Cloning and characterization of a RAB7 gene
172. Acquisition of lipoproteins in the procyclic form of Trypanosoma brucei
173. The Leishmania ABC protein PGPA is an intracellular metal-thiol transporter ATPase
174. Sorting in the endosomal system in yeast and animal cells
175. Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae
176. Immunological purification and partial characterization of varient-specific surface antigen messenger RNA of Trypanosoma brucei
177. Reconstitution of a surface transferrin binding complex in insect form Trypanosoma brucei
178. Characterization of tGLP-1, a Golgi and lysosome-associated, transmembrane glycoprotein of African trypanosomes
179. Phosphoglycosylation of a secreted acid phosphatase from Leishmania donovani
180. Receptor-mediated endocytosis in the procyclic form of Trypanosoma brucei
181. The 63-kilobase circular amplicon of tunicamycin-resistant Leishmania amazonensis contains a functional N-acetylglucosamine-1-phosphate transferase gene that can be used as a dominant selectable market in transfection
182. The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues
183. 2+ pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonesis amastigotes
184. 2+ content and expression of an acidocalcisomal calcium pump are elevated in intracellular forms of Trypanosoma cruzi
185. Golgi GDP-mannose uptake requires Leishmania Lpg2 - A member of a eukaryotic family of putative nucleotide-sugar transporters
186. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER
187. A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule
188. Binding of coatomer by PEX11 C-terminus is not required for function
189. The coatomer of Trypanosoma brucei
190. Galactose-containing glycosylphosphatidyiinositols in Trypanosoma brucei
191. Transfer of glycosylphosphatidylinositol membrane anchors to polypeptide acceptors in a cellfree system
192. Biosynthesis of Trypanosoma brucei variant surface glycoprotein. 1. Synthesis, size, and processing of an N-terminal signal peptide
193. A family of glycoinositol phospholipids from Leishmania major. Isolation, characterization and antigenicity
194. Developmental changes in the glycosylated phospharidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids
195. The glycoinositol phospholipids of Leishmania mexicana promastigotes - Evidence for the presence of three distinct pathways of glycolipid biosynthesis
196. The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes
197. Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids
198. Recent developments in the cell biology and biochemistry of glycosylphosphatidylinositol lipids
199. Structure of Leishmania lipophosphoglycan-inter- and intra-specific polymorphism in Old World species
200. Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage
201. Glycosylphosphatidylinositol-dependent secretory transport in Trypanosoma brucei
202. Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: Insights on safety, target validation, and mechanism of action
203. Trypanosoma brucei GPEET-PARP is phosphorylated on six out of seven threonine residues
204. The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei
205. Plasma membrane targetting, vesicular budding and release of galactin 3 from the cytoplasm of mammalian cells during secretion
206. Designing glycoconjugate biosynthesis for an insidious intent: Phosphoglycan assembly in Leishmania parasites
207. Roles of free GPIs in amastigotes of Leishmania
208. A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: Topography of two GPI pathways
209. Novel (rhamnose and ribosyl) and uncommon (xylosyl) monosaccharide residues are present in asparagine-linked oligosaccharide of the trypanosomatid Blastocrithidia culicis
210. A novel glycosylphosphatidylinositol in African trypanosomes; a possible catabolic intermediate
211. The fine structure of acidocalcisomes in Trypanosoma cruzi
212. The structure of Leishmania major amastigote lipophosphoglycan
213. The major surface antigens of Entamoeba histolytica trophozoites are GPI-anchored proteophosphoglycans
214. Isolation and characterization of the Golgi complex of the protozoan Trypanosoma cruzi
215. Developmental and morphological regulation of clathrin-mediated endocytosis in Trypanosoma brucei
216. Glycosyl phosphatidylinositol myristoylation in African trypanosomes. New intermediates in the pathway for fatty acid remodeling
217. Specialized fatty acid synthesis in African trypanosomes: Myristate for GPI anchors
218. Characterization of a novel GDP-mannose:serineprotein mannose-l-phosphotransferase from Leishmania mexicana
219. +-antiporter involved in glucose symport. Studies with sealed ghosts and vesicles of opposite polarity
220. Regulated degradation of ER membrane proteins in a novel tubular lysosome in Leishmania mexicana
221. Protein sorting upon exit from the endoplasmic reticulum
222. Intracellular transport of GPI-anchored proteins
223. Carbohydrate and LPG expression in Leishmania viannia subgenus
224. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei
225. African trypanosmes have differentially expressed genes encoding homologues of the Leishmania GP63 surface protease
226. Identification of a 44 kDa protein localized within the endoplasmic reticulum of Trypanosoma brucei brucei
227. Biosynthesis of lipophosphoglycan from Leishmania major: Characterization of β(1-3)-galactosyltransferase(s)
228. Biosynthesis of lipophosphoglycan from Leishmania major: Solubilization and characterization of a β(1-3)galactosyltransferase
229. Differential sorting and post-secretory targeting of proteins in parasitic invasion
230. SNAREs and membrane fusion in the Golgi apparatus
231. N-linked glycans containing linear poly-N-acetyllactosamine as sorting signals in endocytosis in Trypanosoma brucei
232. Characterization of a novel alanine-rich protein located in surface microdomains in Trypanosoma brucei
233. Characterization of a novel, stagespecific, invariant surface protein in Trypanosoma brucei containing an internal, serine-rich, repetitive motif
234. Identification of the gene family encoding the 160-kilodalton Trypanosoma cruzi complement regulatory protein
235. Characterization of the Trypanosoma brucei homologue of a Trypanosoma cruzi flagellum-adhesion glycoprotein
236. Both IgM and IgG anti-VSG antibodies intiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite
237. Conditional expression of glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei
238. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
239. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8
240. Purificaion and characterisation of an extracellularly released protease of Trypanosoma brucei
241. The cytostome of Trypanosoma cruzi epimastigotes is associated with the flagellar complex
242. Structures of the N-linked oligosaccharides of gp63, the major surface glycoprotein, from Leishmania mexicana amazonensis
243. Antigen presentation by macrophages harboring intravesicular pathogens
244. Endocytosis and secretion in trypanosomatid parasites - Tumultuous traffic in a pocket
245. A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei
246. Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a GPI-specific endosomal pathway
247. N-glycosylation in trypanosomatid protozoa
248. Reglucosylation of glycoprotein and quality control of glycoprotein folding in the endoplasmic reticulum of yeast cells
249. Role of N-oligosaccharide endoplasmic reticulum processing reactions in glycoprotein folding and degradation
250. The presence of complex-type oligosaccharides at the C-terminal domain glycosylation site of some molecules of cruzipain
251. A role for the dynamic acylation of a cluster of cysteine residues in regulating the activity of the glycosylphosphatidylinositol-specific phospholipase C of Trypanosoma brucei
252. Expression of a variant surface glycoprotein of Trypanosoma gambiense in procyclic forms of Trypanosoma brucei shows that the cell type dictates the nature of the glycosylphosphatidylinositol membrane anchor attached to the glycoprotein
253. Fatty acid synthesis in African trypanosomes: A solution to the myristate mystery
254. Expression and function of surface proteins in Trypanosoma brucei
255. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)
256. Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-cogalactosyl antibodies
257. Secreted proteophosphoglycan of Leishmania mexicana amastigotes activates complement by triggering the mannan binding lectin pathway
258. Leishmania major proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function
259. Fine structure and cytochemistry of the endoplasmic reticulum and its association with the plasma membrane of Leishmania mexicana amazonensis
260. The comparative fine structure and surface glycoconjugate expression of three life stages of Leishmania major
261. Differential targeting of two glucose transporters from Leishmania enriettii is mediated by an NH2-terminal domain
262. Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carrier operating between Golgi apparatus and plasma membrane
263. Trypanosoma cruzi surface mucins with exposed variant epitopes
264. Characterization of a novel trans-sialidase of Trypanosoma brucei procyclic trypomastigotes and identification of procyclin as the main sialic acid acceptor
265. Trypanosoma cruzi epimastigote endocytic pathway: Cargo enters the cytostome and passes through an early endosomal network before storage in reservosomes
266. Possible localisation of dolichol-dependent mannosyltransferases of Trypanosoma brucei to the rough endoplasmic reticulum
267. O-glycosidically linked N-acetylglucosaminebound oligosaccharides from glycoproteins of Trypanosoma cruzi
268. Leishmania adleri, a lizard parasite, expresses structurally similar glycoinositolphospholipids to mammalian Leishmania
269. Structural characterization of the major glycosylphosphatidylinositol membrane-anchored glycoprotein from epimastigote forms of Trypanosoma cruzi Y-strain
270. Biosynthesis of O-N-acetylglucosamine-linked glycans in Trypanosoma cruzi. Characterization of the novel uridine diphospho-N-acetylglucosamine:polypeptide N-acetylglucosaminyltransferase-catalyzing formation of N-acetylglucosamine-α-1-O-threonine
271. Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major
272. Serum resistance of metacyclic stage Leishmania major promastigotes is due to release of C5b-9
273. Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana - Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling
274. The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine
275. Intracellular trafficking of GPI-anchored proteins and free GPIs in Leishmania mexicana
276. The geneB protein localises to the surface of Leishmania major parasites in the absence of metacyclic stage lipophosphoglycan
277. The giycoinositol-phospholipids of Phytomonas
278. Polar transmembrane domains target proteins to the interior of the yeast vacuole
279. Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes
280. Biochemical characterization of the protective membrane glycoprotein GP46/M-2 of Leishmania amazonensis
281. Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle
282. Unravelling the procyclin coat of Trypanosoma brucei
283. +-ATPase
284. Molecular cloning and biochemical characterization of a VCP homolog in African trypanosomes
285. Isolation and characterization of subnuclear compartments from Trypanosoma brucei. Identification of a major repetitive nuclear lamina component
286. Characterization of the elongating α-D-mannosyl phosphate transferase from three species of Leishmania using synthetic acceptor substrate analogues
287. The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes
288. Rapid changes in polyphosphate content within acidocalcisomes in response to cell growth, differentiation and environmental stress in Trypanosoma cruzi
289. Trypanosoma cruzi: Monoclonal antibody to cytoskeleton recognizes giant proteins of the flagellar attachment zone
290. Biology of the Leishmania surface - With particular reference to the surface proteinase, GP63
291. Leishmania-sand fly interactions controlling species-specific vector competence
292. The role of phosphoglycans in Leishmania-sand fly interactions
293. A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei
294. Cloning and functional expression of a gene encoding a PI type nucleoside transporter from Trypanosoma brucei
295. A family of putative receptor-adenylate cyclases from Leishmania donovani
296. Changes in lipophosphoglycan and gene expression associated with the development of Leishmania major in Phlebotomus papatasi
297. Purification and characterization of a tartrate-sensitive acid phosphatase of Trypanosoma brucei
298. Structural and functional properties of Trypanosoma cruzi trans-sialidase
299. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi
300. A microtubulebinding protein of Trypanosoma brucei which contain covalently bound fatty acid
301. Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease
302. p, in Leishmania major lipophosphoglycan
303. Characterization of glycoinositol phospholipids in the amastigote stage of the protozoan parasite Leishmania major
304. Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains
305. Structural studies on a lipoarabinogalactan of Crithidia fasciculata
306. Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi
307. +-ATPase are involved in the acidification of internal compartments in Trypanosoma cruzi
308. In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi
309. A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast
310. Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
311. ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
312. Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis
313. Degradation, recycling, and shedding of Trypanosoma brucei variant surface glycoprotein
314. Pathogenic Leishmania secrete antigenically related chitinases which are encoded by a highly conserved gene locus
315. Coated vesicles from the protozoan parasite Trypanosoma brucei: Purification and characterization
316. Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins
317. A cell-free assay for glycosylphosphatidylinositol anchoring in African trypanosomes - Demonstration of a transamidation reaction mechanism
318. The lysosomal targeting and intracellular metabolism of trypanosome lytic factor by Trypanosoma brucei brucei
319. Cell invasion by un-palatable parasites
320. Parasite -specific inhibition of the glycosylphosphatidylinositol biosynthetic pathway by stereoisomeric substrate analogues
321. Cell surface components of Leishmania: Identification of a novel parasite lectin
322. Specificity of GIcNAc-PI de-Nacetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors
323. Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania
324. Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei
325. Characterization of a targeting motif for the flagellar membrane protein in Leishmania enriettii
326. Cytoskeletal association is important for differential targeting of glucose transporter isoforms in Leishmania
327. Identification of a large pre-lysosomal compartment in the pathogenic protozoon Trypanosoma cruzi
328. Quick-freeze, deep-etch rotary replication of Trypanosoma cruzi and Herpetomonas megaseliae
329. Trypanosoma cruzi: Ultrastructural, cytochemical and freeze-fracture studies of protein uptake
330. Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
331. A primer on vesicle budding
332. Tryypanosoma brucei with an active metacyclic variant surface gene expression site expresses a transferrin receptor derived from Esag6 and Esag7
333. ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex
334. Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei
335. Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three-dimensional networks that obstruct the digestive tract of infected sandfly vectors
336. Characterization of polymer release from the flagellar pocket of Leishmania mexicana promastigotes
337. Structure of a filamentous phosphoglycoprotein polymer: The secreted acid phosphatase of Leishmania mexicana
338. Stage-specific glycosphingolipids from amastigote forms of Leishmania (L.) amazonensis. Immunogenicity and role in parasite binding and invasion of macrophages
339. Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast
340. A partial cDNA clone of trypomastigote decay-accelerating factor (T-DAF), a developmentally regulated complement inhibitor of Trypanosoma cruzi, has genetic and functional similarities to the human complement inhibitor DAF
341. Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the Golgi apparatus
342. A differentially expressed gene family encoding "amastin," a surface protein of Trypanosoma cruzi amastigotes
343. Structure of O-glycosidically linked oligosaccharides from glycoproteins of Trypanosoma cruzi CL-Brener strain: Evidence for the presence of O-linked sialyl-oligosaccharides
344. Lectins as chaperones in glycoprotein folding
345. Signal-dependent membrane protein trafficking in the endocytic pathway
346. Is lipophosphoglycan a virulence factor? A surprising diversity, between Leishmania species
347. Megasome biogenesis in Leishmania amazonensis: A morphometric and cytochemical study
348. Impairment of sterol biosynthesis leads to phosphorus and calcium accumulation in Leishmania acidocalcisomes
349. A major surface glycoprotein of Trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia
350. Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant
351. The fine structure of Trypanosoma congolense in its bloodstream phase
352. On the surface coat and flagellar adhesion in trypanosomes
353. Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer
354. The GPI anchor of cell-surface proteins is synthesized on the cytoplasmic face of the endoplasmic reticulum
355. Segregation of glycosylphosphatidylinositol biosynthetic reactions in a subcompartment of the endoplasmic reticulum
356. Endocytosis by African trypanosomes. I. Three-dimensional structure of the endocytic organelles in Trypanosoma brucei and T. congolense
357. Endocytosis by African trypanosomes. II. Occurrence in different life-cycle stages and intracellular sorting
358. Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Tryponosoma brucei
359. The interaction of Trypanosoma brucei with antibodies to variant surface glycoproteins
360. Distribution of GPI-anchored proteins in the protozoan parasite Leishmania, based on an improved ultrastructural description using high-pressure frozen cells
361. Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
362. Gene cloning and cellular localization of a membranebound acid phosphatase of Leishmania mexicana
363. Expression and species-specific glycosylation of Leishmania mexicana secreted acid phosphatase in Leishmania major
364. Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase
365. Surface antigens of Leishmania mexicana amastigotes-characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid
366. Antigen presentation by Leishmania mexicana-infected macrophages: Activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites
367. Evidence for a Mr 88,000 glycoprotein with a transmembrane association to a unique flagellum attachment region in Trypanosoma brucei
368. A new developmentally regulated gene family in Leishmania amastigotes encoding a homologue of amastin surface proteins
369. Characterization of a Leishmania antigen associated with cytoplasmic vesicles resembling an endosomal-like structure
370. Sequence requirements for trafficking of the CRAM transmembrane protein to the flagellar pocket of African trypanosomes
371. Glycosylation in parasitic protozoa of the trypanosomatidae family
372. The glycoinositolphospholipids from Leishmania panarmensis contain unusual glycan and lipid moieties
373. Organization of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei
374. Transport of nutrients and ions across membranes of trypanosomatid parasites
375. Protein structure controls the processing of the N-linked oligosaccharides and glycosylphosphatidylinositol glycans of variant surface glycoproteins expressed in bloodstream form Trypanosoma brucei