Designing glycoconjugate biosynthesis for an insidious intent: Phosphoglycan assembly in Leishmania parasites

Glycobiology

Volumn 7, Issue 7, 1997, Pages 873-880

  Mengeling, Brenda Jo ^a,b   Beverley, Stephen M ^a   Turco, Salvatore J ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Glycoconjugate biosynthesis; Leishmania; Lipophosphoglycan; Phosphoglycans; Proteophosphoglycan

Indexed keywords

ACID PHOSPHATASE; GLYCOCONJUGATE; LIPOPHOSPHOGLYCAN; PROTEOGLYCAN;

BIOSYNTHESIS; ENZYME ACTIVITY; LEISHMANIA; LIFE CYCLE; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; REACTION ANALYSIS; SHORT SURVEY;

EID: 0030668764     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/7.7.873-c     Document Type: Short Survey

References (60)

1. Antoine, J. -C, Prina. E., Jouanne. C. and Bongrand. P. (1990) Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH. Infect. Immun., 58, 779-787.
2. Brown, G. M., Millar. A. R., Masterson. C, Brimacombe, J. S., Nikolaev, A. V. and Ferguson, M. A. J. (1996) Synthetic phospho-oligosaccharide fragments of lipophosphoglycan as acceptors for Leishmania major alpha-D-mannosylphosphate transferase. Eur. J. Biochem., 242, 410-416.
3. Butcher, B. A., Turco. S. J., Hilty. B. A., Pimenta, P. F., Panunzio. M. and Sacks. D. L. (1996) Deficiency in β1,3-galactosyltransferase of a Leishmania major lipophosphoglycan mutant adversely influences the Leishmania sand fly interaction. J. Biol. Chem., 271, 20573-20579.
4. Carver, M. A. and Turco. S. J. (1991) Cell-free biosynthesis of lipophosphoglycan from Leishmania donovani. Characterization of microsomal galactosyltransferase and mannosyltransferase activities. J. Biol. Chem., 266, 1097410981.
5. Carver, M. A. and Turco. S. J. (1992) Biosynthesis of lipophosphoglycan from Leishmania donovani: characterization of mannosylphosphate transfer in vitro. Arch. Biochem. Biophys. . 295, 309-317.
6. Cohn, Z. A. and Ehrenreich. B. A. (1969) The uptake, storage, and intracellular hydrolysis of carbohydrates in macrophages. J. Exp. Med., 129, 201-225.
7. DaSilva, R. P., Hall, B. F., Joiner, K. A. and Sacks. D. L. (1989) CRI, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages. J. Imnmnol., 143, 617-622.
8. De Lederkremer, R. M. and Colli. W. (1995) Galactofuranose-containing glycoconjugates in trypanosomatids. Glycobiology, 5, 547-552.
9. Descoteaux, A., Matlashewski. G. and Turco. S. J. (1992) Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan. J. ImnumoL, 149, 3008-3015.
10. Descoteaux, A., Luo, Y., Turco. SJ. and Beverley. S. M. (1995) A specialized pathway affecting virulence glycoconjugates of Leishmania. Science, 269, 1869-1872.
11. Elhay, M., Kelleeher. M., Bacic. A., McConville. M. J., Tolson. D. L., Pearson. T. W. and Handman. E. (1990) Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major. Mol. Biochem. Parasitai, 40, 255-268.
12. Franke, E. D., McGreevy. P. B., Katz. S. P. and Sacks. D. L. (1985) Growth cycledependent generation of complement-resistant Leishmania promastigotes. J. Immwwl., 134, 2713-2718.
13. Giorgione, J. R., Turco, S. J. and Epand. R. M. (1996) Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani. Proc. Nail Acad. Sei. USA, 93, 11634-11639.
14. Greis, K. D., Turco. S. J., Thomas, J. R., McConville. M. J., Homans. S. W. and Ferguson. M. A. J. (1992) Purification and characterization of an extracellular phosphoglycan from Leishmania donovani. J. Biol. Client., 267, 5876-5881.
15. Hirschberg, C. B. (1996) Transporters of nucleotides and nucleotide derivatives in the endoplasmic reticulum and Golgi apparatus. In Clapham. D. E. and. Ehrlich. B. E (eds. ), Organeller Ion Channels and Transporters. Rockefeller University Press, New York, pp. 105-120.
16. Homans, S. W., Mehlert. A. and Turco. S. J. (1992) Solution structure of the lipophosphoglycan of Leishmania donovani. Biochemistry, 31, 654-661.
17. Huang, C. and Turco. S. J. (1993) Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani. J. Biol. Chem., 268, 24060-24066.
18. Ilg, T., Menz, B., Winter. G., Russell. D. G., Etges. R., Schell. D. and Overath. P. (199la) Monoclonal antibodies to Leishmania mexicana promastigote antigens. I. Secreted acid phosphatase and other proteins share epitopes with lipophosphoglycan. J. Cell Sei., 99, 175-180.
19. Ilg, T., Stierhof, Y. -D., Etges. R., Adrian. M., Harbecke. D. and Overath. P. (I991b) Secreted acid phosphatase of Leishmania mexicana: a filamentous phosphoglycoprotein polymer. Proc. Natl. Acad. Sei. USA, 88, 8774-8778.
20. Ilg, T., Etges, R., Overath. P., McConville. M. J., Thomas-OatesJ., Thomas, J., Homans. S. W. and Ferguson. M. A. J. (1992) Structure of Leishmania mexicana lipophosphoglycan. J. Biol. Chem., 267, 6834-6840.
21. Ilg, T., Overath. P., Ferguson. M. A. J., Rutherford. T., Campbell. D. G. and McConville. M. J. (1994a) O- and TV-glycosylation of the Leishmania mexicanasecreted acid phosphatase. Characterization of a new class ofphosphoserinelinked glycans. J. Biol Chem., 269, 24073-24081.
22. Ilg, T., Stierhof, Y. -D., Wiese. M., McConville. M. J. and Overath. P. (1994b) Characterization of phosphoglycan-containing secretory products of Leishmania. Parasitology, 108 (Suppl. ), S63-S71.
23. Ilg, T., Stierhof, Y. -D., McConville. M. J. and Overath. P. (1995) Purification, partial characterization and immunolocalization of a proteophosphoglycan secreted by Leishmania mexicana amastigotes. Eur. J. Cell Biol., 66, 205215.
24. Ilg, T., Stierhof. Y. D., Craik. D., Simpson. R., Handman. E., and Bacic. A. (1996) Purification and structural characterization of a filamentous, mucin-like proteophosphoglycan secreted by Leishmania parasites. J. Biol. Chem., 271, 21583-21596.
25. Kelleher, M., Moody. S. F., Mirabile. P., Osborn. A. H., Bacic. A. and Handman. E. (1995) Lipophosphoglycan blocks attachment of Leishmania major amastigotes to macrophages. Infect. Immun., 63, 43-50.
26. Killick-Kendrick, R., Wallbanks. K. R., Molyneux. D. H. and Lavin. D. R. (1988) The ultrastructure of Leishmania major in the foregut and proboscis of Phlebotomus papatasi. Parasitai. Res., 74, 586-590.
27. King, D. L. and Turco. S. J. (1988) A ricin agglutinin-resistant clone of Leishmania donovani. Mol. Biochem. Parasitai, 28, 285-294.
28. Lang, T., Hellio. R., Kaye. P. M. and Antoine, J. -C. (1994) Leishmania donovaniinfected macrophages: characterization of the parasitophorous vacuole and potential role of this organelle in antigen presentation. J. Cell Sei., 107, 2137-2150.
29. Lawyer, P. G., Ngumbi. P. M., Anjili. C. O., Odongo. S. O., Mebrahtu. Y. B., Githure. J. 1., Koech. D. K. and Roberts. C. R. (1990) Development of Leishmania major in Phlebotomus duboscqi and Sergentomyia schwetzi (Diptera: Psychodidae) Am. J. Trop. Med. Hyg., 43, 31-43.
30. Lovelace, J. K. and Gottlieb. M. (1986) Comparison of extracellular acid phosphatase from various isolates of Leishmania. Am. J. Trap. Med. Hyg., 35, 1121-1128.
31. Ma, D., Russell, D. G., Beverley. S. M. and Turco. S. J. (1997) Golgi GDPMannose uptake requires Leishmania LPG2. A member of a eukaryotic family of putative nucleotide-sugar transporters. J. Biol. Chem., 272, 37993805.
32. McConville, M. J. and Blackwell. J. M. (1991) Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastiaote glycolipids. J. Dial. Client., 266, 15170-15179.
33. McConville, M. J. and Ferguson. M. A. J. (1993) The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem. J., 294, 305-324.
34. McConville, M. J. and Homans. S. W. (1992) Identification of the defect in lipophosphoglycan biosynthesis in a non-pathogenic strain of Leishmania major. J. Biol. Chem., 267, 5855-5861.
35. McConville, M. J., Thomas-Oates. J. E., Ferguson. M. A. J. and Homans. S. W. (1990) Structure of the lipophosphoglycan from Leishmania major. J. Biol. Chem., 265, 19611-19623.
36. McConville, M. J., Turco. S. J., Ferguson. M. AJ. and Sacks. D. L. (1992) Developmental modification of lipophosphoglycan during the differentiation of Leishmania majorpromastigotes loan infectious stage. EMBOJ., 11, 35933600.
37. McConville, MJ., Schnur. L. F., Jaffe. C. L. and Schneider, ?. (1995) Structure of Leishmania lipophosphoglycan: inter-and intra-specific polymorphism in Old World species. Biochem. J., 310, 807-818.
38. McNeely, T. B., Rosen. G., Londner. M. V. and Turco. SJ. (1989) Inhibitory effects on protein kinase C by lipophosphoglycan and glycosyl-phosphatidylinositol antigens of Leishmania. Biochem. J., 259, 601-604.
39. McNeely, T. B. and Turco. SJ. (1990) Requirement of lipophosphoglycan for intracellular survival of Leishmania donovani with human monocytes. J. Imnmnol., 144, 2745-2750.
40. Mengeling, BJ., Zilberstein. D. and Turco. S. J. (1997) Biosynthesis of Leishmania lipophosphoglycan: solubilization and partial characterization of the initiating mannosylphosphoryltransferase. Glycobiology, 1, 847-853.
41. Moody, S. F., Handman. E. and Bacic. A. (1991) Structure and antigenicity of the lipophosphoglycan from Leishmania major amastigotes. Glycobiology, 1, 419-24.
42. Mosser, D. M., Springer. T. A. and Diamond. M. S. (1992) Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CDllb/CD18). y. Cell Biol. 116, 511-520.
43. Ng, K., Handman. E. and Bacic. A. (1996) Biosynthesis of lipophosphoglycan from Leishmania major: solubilization and characterization of a (ßl-3)galactosyltransferase. Biochem. J., 317, 247-255.
44. Orlandi, P. A. and Turco. S. J. (1987) Structure of the lipid moiety of the Leishmania donovani lipophosphoglycan. J. Biol. Chem., 262, 1038410391.
45. Pimenta, P. F. P., Turco. SJ., McConville. M. J., Lawyer. P. G., Perkins. P. V. and Sacks. D. L. (1992) Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut. Science, 256, 1812-1815.
46. Pimenta, P. F. P., Saraiva. E. M. B., Rowton. E., Modi. G. B., Garraway. L. A., Beverley. S. M., Turco. S. J. and Sacks. D. L. (1994) Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan. Proc. Nail. Acad. Sei. USA, 91, 9155-9159.
47. Puentes, S. M., Sacks. D. L., Da Silva. R. P. and Joiner. K. A. (1988) Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan. J. Exp. Med., 167, 887-902.
48. Puentes, S. M., Da Silva. R. P., Sacks. D. L., Hammer. C. H. and Joiner. K. A. (1990) Serum resistance of metacyclic stage Leishmania major promastigotes is due to release of C5b-9. J. Immunol., 145, 4311-4316.
49. Ryan, K. A., Garraway, L. A., Descoteaux, A., Turco. S. J. and Beverley. S. M. (1993) Isolation of virulence genes directing surface glycosylphosphatidylinositol synthesis by functional complementation of Leishmania. Proc. Natl. Acad. Sei. USA, 90, 8609-8613.
50. Sacks, D. L., Brodin. T. N. and Turco. S. J. (1990) Developmental modification of the lipophosphoglycan from Leishmania major promastigotes during metacyclogenesis. Mol. Biochem. Parasitai., 42, 225-233.
51. Sacks, D. L., Saraiva, E. M., Rowton. E., Turco. S. J. and Pimenta, . F. (1994) The role of the lipophosphoglycan of Leishmania in vector competence. Parasitology, 108 (Suppl. ), S55-S62.
52. Saraiva, E. M. B., Pimenta. P. F. P., Brodin. T. N., Rowton. E., Modi. G. B. and Sacks. D. L. (1995) Changes in lipophosphoglycan and gene expression associated with the development of Leishmania major in Phlebotomus papatasi. Parasilology, 111, 275-287.
53. Smith, T. K., Cottaz. S., Brimacombe, J. S. and Ferguson. M. AJ. (1996) Substrate specificity of the dolichol phosphate mannose: glucosaminyl phosphatidylinositol al-l-mannosyltransferase of the glycosylphosphatidylinositol bio-synthetic pathway of African trypanosomes. J. Biol. Chem., 271, 64766482.
54. Sogin, M. L. and GundersonJ. H. (1987) Structural diversity of eukaryotic small subunit ribosomal RNAs. Evolutionary implications. Ann. N. Y. Acad. Sei., 503, 125-139.
55. Stierhof, Y. -D., Ilg. T., Russell. D. G., Hohenberg. H. and Overath, P. (1994) Characterization of polymer release from the flagellar pocket of Leishmania mexicana promastigotes. J. Cell Biol., 125, 321-331.
56. Turco, S. J. and Descoteaux. A. (1992) The lipophosphoglycan of Leishmania parasites. Anna. Rev. Microbiol., 46, 65-94.
57. Turco, S. J. and Sacks, D. L. (1991) Expression of a stage-specific lipophosphoglycan in Leishmania major amastieotes. Mol. Biochem. Parasitai., 45, 91-100.
58. Walters, L. L., Modi. G. B., Tesh. R. B. and Burrage. T. (1987) Host-parasite relationship of Leishmania mexicana mexicana and Lntzomyia abonnenci (Diptera: psychodidae) /1m. J. Trop. Meet. Hyg., 36, 294-314.
59. Warburg, A. and Schlein. Y. (1986) The effect of post-bloodmeal nutrition of Phlebotomits papatasi on the transmission of Leishmania major. Am. J. Trop. Med. Hyg., 35, 926-930.
60. Wiese, M., Ilg. T., Lottspeich, F. and Overath. P. (1995) Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase. EMBO J., 14, 1067-1074.