The mucin-like glycoprotein super-family of Trypanosoma cruzi: Structure and biological roles

Molecular and Biochemical Parasitology

Volumn 114, Issue 2, 2001, Pages 143-150

  Acosta Serrano, Alvaro ^a,d   Almeida, Igor C ^b   Freitas Junior, Lucio H ^c   Yoshida, Nobuko ^c   Schenkman, Sergio ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Glycosylation; GPI; Mucins; Sialic acid; Trans sialidase; Trypanosoma cruzi

Indexed keywords

CYTOKINE; GLYCAN DERIVATIVE; GLYCOINOSITOLPHOPHOLIPID; GLYCOPROTEIN; MUCIN; N ACETYLGLUCOSAMINE; NITRIC OXIDE; PHOSPHOLIPID; PROLINE; SERINE; SIALIDASE; THREONINE; UNCLASSIFIED DRUG;

CELL INVASION; CYTOKINE RELEASE; HOST CELL; MACROPHAGE ACTIVATION; MEDIATOR RELEASE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; REVIEW; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; CARBOHYDRATE SEQUENCE; CHAGAS DISEASE; GLYCOPROTEINS; HUMANS; INSECTS; MACROPHAGES; MAMMALS; MOLECULAR SEQUENCE DATA; MUCINS; MULTIGENE FAMILY; OLIGOSACCHARIDES; PROTOZOAN PROTEINS; TRYPANOSOMA CRUZI;

INSECTA; MAMMALIA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0034986265     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(01)00245-6     Document Type: Review

References (67)

1. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi
2. Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi
3. O-glycosidically linked N-acetylglucosamine-bound oligosaccharides from glycoproteins of Trypanosoma cruzi
4. The structure and assembly of secreted mucins
5. Glycoproteins from Trypanosoma cruzi: Partial purification by gel chromatography
6. A lipopeptidophosphoglycan from Trypanosoma cruzi (epimastigota). Isolation, purification and carbohydrate composition
7. Primary structure of the oligosaccharide chain of lipopeptidophosphoglycan of epimastigote forms of Trypanosoma cruzi
8. Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi epimastigotes
9. Structural variation in the glycoinositolphospholipids of different strains of Trypanosoma cruzi
10. Incorporation of sialic acid into Trypanosoma cruzi macromolecules. A proposal for a new metabolic route
11. Comparative compositions of cell surface glycoconjugates isolated from Trypanosoma cruzi epimastigotes
12. Expression of a novel cell surface lipophosphoglycan-like glycoconjugate in Trypanosoma cruzi epimastigotes
13. Alteration of macrophage function by a Trypanosoma cruzi membrane mucin
14. Metacyclic neutralizing effect of monoclonal antibody 10D8 directed to the 35- and 50-kilodalton surface glycoconjugates of Trypanosoma cruzi
15. Stage-specific surface antigens expressed during the morphogenesis of vertebrate forms of Trypanosoma cruzi
16. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells
17. Glycosylphosphatidylinositol anchored mucin-like glycoproteins (GPI-mucins) purified from Trypanosoma cruzi intracellular amastigotes are potent inducers of pro-inflammatory cytokines and nitric oxide by macrophages
18. A sialidase activity in the midgut of the insect Triatoma infestans is responsible for the low levels of sialic acid in Trypanosoma cruzi growing in the insect vector
19. Structural and functional properties of Trypanosoma trans-sialidase
20. Trans-sialidase: A unique enzyme activity discovered in the protozoan Trypanosoma cruzi
21. Stage-specific expression and intracellular shedding of the cell surface trans-sialidase of Trypanosoma cruzi
22. Trypanosoma cruzi mucins: Potential functions of a complex structure
23. The lipid structure of the glycosylphosphatidylinositol-anchored mucin-like sialic acid acceptors of Trypanosoma cruzi changes during parasite differentiation from epimastigotes to infective metacyclic trypomastigote forms
24. Separation of Galfβ1-XGlcNAc and Galpβ1-XGlcNAc (X=3, 4, and 6) as the alditols by high-pH anion-exchange chromatography and thin-layer chromatography: Characterization of mucins from Trypanosoma cruzi
25. Direct lysis of Trypanosoma cruzi: A novel effector mechanism of protection mediated by human anti-gal antibodies
26. GPI-anchored glycoconjugates from Trypanosoma cruzi trypomastigotes are recognized by lytic anti-α-galactosyl antibodies isolated from patients with chronic Chagas' disease
27. The N-linked carbohydrate chain of the 85-kilodalton glycoprotein from Trypanosoma cruzi trypomastigotes contains sialyl, fucosyl and galactosyl (alpha 1-3)galactose units
28. Biosynthesis of O-N-acetylglucosamine-linked glycans in Trypanosoma cruzi. Characterization of the novel uridine diphospho-N-acetylglucosamine:Polypeptide N-acetylglucosaminyltransferase-catalyzing formation of N-acetylglucosamine α1-O-threonine
29. The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions
30. AU-rich Elements in the 3′-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency
31. Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins
32. Structural characterization of the major glycosylphosphatidylinositol membrane-anchored glycoprotein from epimastigote forms of Trypanosoma cruzi Y-strain
33. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages
34. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents
35. Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania species membranes trigger nitric oxide synthesis as well as microbicidal activity in IFN-gamma-primed macrophages
36. The trans-sialidase of Trypanosoma cruzi is anchored by two different lipids
37. Glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae: Absence of ceramides from complete precursor glycolipids
38. Evidence for phospholipases from Trypanosoma cruzi active on phosphatidylinositol and inositolphosphoceramide
39. Polymorphism of the 35- and 50-kilodalton surface glycoconjugates of Trypanosoma cruzi metacyclic trypomastigotes
40. Sialic acid acceptors of different stages of Trypanosoma cruzi are mucin-like glycoproteins linked to the parasite membrane by GPI anchors
41. Mucin-like glycoprotein genes are closely linked to members of the trans-sialidase super-family at multiple sites in the Trypanosoma cruzi genome
42. Two distinct groups of mucin-like genes are differentially expressed in the developmental stages of Trypanosoma cruzi
43. Expression of trans-sialidase and 85-kDa glycoprotein genes in Trypanosoma cruzi is differentially regulated at the post-transcriptional level by labile protein factors
44. The 35/50 kDa surface antigen of Trypanosoma cruzi metacyclic trypomastigotes, an adhesion molecule involved in host cell invasion
45. 2+ signal induced by Trypanosoma cruzi metacyclic trypomastigote surface molecules implicated in mammalian cell invasion
46. Signaling and host cell invasion by Trypanosoma cruzi
47. Removal of sialic acid from mucin-like surface molecules of Trypanosoma cruzi metacyclic trypomastigotes enhances parasite-host cell interaction
48. 2+ signalling activity
49. Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion
50. A surface antigen of Trypanosoma cruzi involved in cell invasion (Tc-85) is heterogeneous in expression and molecular constitution
51. Involvement of the stage-specific 82-kilodalton adhesion molecule of Trypanosoma cruzi metacyclic trypomastigotes in host cell invasion
52. Trypanosoma cruzi 175-kDa protein tyrosine phosphorylation is associated with host cell invasion
53. Mammalian cell sialic acid enhances invasion by Trypanosoma cruzi
54. Attachment of Trypanosoma cruzi trypomastigotes to receptors at restricted cell surface domains
55. Mediation of Trypanosoma cruzi invasion by sialic acid on the host cell and trans-sialidase on the trypanosome
56. Interaction of Trypanosoma cruzi with cells with altered glycosylation patterns
57. Evidence for the participation of the Ssp-3 antigen in the invasion of nonphagocytic mammalian cells by Trypanosoma cruzi
58. Enzymatically inactive members of the trans-sialidase family from Trypanosoma cruzi display β-galactose binding activity
59. Coculture of human peripheral blood mononuclear cells with Trypanosoma cruzi leads to proliferation of lymphocytes and cytokine production
60. Tumor necrosis factor α mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected g interferon-activated macrophages
61. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
62. Galactofuranose-containing glycoconjugates of epimastigote and trypomastigote forms of Trypanosoma cruzi
63. Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-(alpha)-galactosyl antibodies
64. Gastric invasion by Trypanosoma cruzi and induction of protective mucosal immune responses
65. Role of sialic acid in the resistance of Trypanosoma cruzi trypomastigotes to complement
66. Stable transfection of Trypanosoma cruzi epimastigotes with the trypomastigote-specific complement regulatory protein cDNA confers complement resistance
67. Trypanosoma cruzi surface mucins with exposed variant epitopes