Secretory and endocytic pathways converge in a dynamic endosomal system in a primitive protozoan

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Volumn 2, Issue 3, 2001, Pages 175-188

  Ghedin, Elodie ^a,d   Debrabant, Alain ^b   Engel, Juan C ^c   Dwyer, Dennis M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d J CRAIG VENTER INSTITUTE   (United States)

Author keywords

Endocytic pathway; GFP chimeras; Leishmania; Secretory pathway; Trafficking

Indexed keywords

CHIMERIC PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; NUCLEASE; NUCLEOTIDASE;

ARTICLE; CELL COMPARTMENTALIZATION; CELL SURFACE; CELL TRANSPORT; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; EUKARYOTE; FLAGELLUM; LEISHMANIA; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TRANSPORT;

ANIMALS; CELLS, CULTURED; ENDOCYTOSIS; ENDOSOMES; FLAGELLA; GREEN FLUORESCENT PROTEINS; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LUMINESCENT PROTEINS; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0035012676     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.020304.x     Document Type: Article

References (30)

1. Webster P, Russell DG. The flagellar pocket of trypanosomatids. Parasitol Today 1993;9: 201-206.
2. Debrabant A, Ghedin E, Dwyer DM. Dissection of the functional domains of the Leishmania surface membrane 3′-nucleotidase/nuclease, a unique member of the Class I nuclease family. J Biol Chem 2000;275: 16366-16372.
3. Roberts SC, Swihart KG, Agey MW, Ramamoorthy R, Wilson ME, Donelson JE. Sequence diversity and organization of the msp gena family encoding gp63 of Leishmania chagasi. Mol Biochem Parasitol 1993;62: 157-172.
4. Webster P, Joiner K, Andrews NW. Why do so many surface proteins of trypanosomatids have GPI-anchors? Cell Biol Int Rep 1991;15: 799-813.
5. Ferguson MAJ. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J Cell Sci 1999;112: 2799-2809.
6. Ghedin E, Charest H, Zhang WW, Debrabant A, Dwyer D, Matlashewskl G. Inducible expression of suicide genes in Leishmania donovani amastigotes. J Biol Chem 1998;273: 22997-23003.
7. Debrabant A, Gottlieb M, Dwyer DM. Isolation and characterization of the gene encoding the surface membrane 3′-nucleotidase/nuclease of Leishmania donovani. Mol Biochem Parasitol 1995;71: 51-63.
8. Bates PA, Hermes I, Dwyer DM. Leishmania donovani: immunochemical localization and secretory mechanism of soluble acid phosphatase. Exp Parasitol 1989;68: 335-346.
9. Horan P, Slezak S. Stable cell membrane labeling. Nature 1989;340: 167-168.
10. Turco SJ, Descoteaux A. The lipophosphoglycan of Leishmania parasites. Annu Rev Microbiol 1992;46: 65-94.
11. Overath P, Stierhof YD, Wiese M. Endocytosis and secretion in trypanosomatid parasites - tumultuous traffic in a pocket. Trends Cell Biol 1997;7: 27-33.
12. Upsky NG, Pagano RE. Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucosylcerebroside analogues pass through the Golgi apparatus en route to the plasma membrane. J Cell Biol 1935;100: 27-34.
13. Pagano RE, Martin OC, Kang HC, Haughland RP. A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor. J Cell Biol 1991;113: 1267-1279.
14. Traub LM, Kornfeld S. The trans-Golgi network: a late secretory sorting station. Curr Opin Cell Biol 1997;9: 527-533.
15. Becker B, Melkonian M. The secretory pathway of protists: spatial and functional organization and evolution. Microbiol Rev 1996;60: 697-721.
16. Allan BB, Balch WE. Protein sorting by directed maturation of Golgi compartments. Science 1999;285: 63-66.
17. Mellman I, Simons K. The Golgi complex: in vitro veritas? Cell 1992;68: 829-840.
18. Alexander J, Vickerman K. Fusion of host cell secondary lysosomes with the parasitophorous vacuoles of Leishmania infected macrophages. J Parasitol 1975;22: 502-508.
19. Coombs GH, Tetley L, Moss VA, Vickerman K. Three-dimensional structure of the Leishmania amastigote as revealed by computer-aided reconstruction from serial section. Parasitology 1986;92: 13-23.
20. Lu H-L, Zhong L, Chang K-P, Docampo R. Intracellular Ca2 + pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonensis amastigotes. J Biol Chem 1997;14: 9464-9473.
21. Ilgoutz SC, Mullin KA, Southwell BR, McConville MJ. Glycosylphosphatidylinositol biosynthetic enzymes are localized to a stable tubular subcompartment of the endoplasmic reticulum in Leishmania mexicana. EMBO J 1999;18: 3643-3654.
22. Bates PA, Hermes I, Dwyer DM. Golgi-mediated post-translational processing of secretory acid phosphatase by Leishmania donovani promastigotes. Mol Biochem Parasitol 1990;392: 247-256.
23. Brickman MJ, Balber AE. Transport of a lysosomal membrane glycoprotein from the Golgi to endosomes and lysosomes via the cell surface in African trypanosomes. J Cell Sci 1994;107: 3191-3200.
24. Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, McKerrow JH. Cysteine protease Inhibitors as chemotherapy: lessons from a parasite target. Proc Nat Acad Sci USA 1999;96: 11015-11022.
25. McDowell MA, Ransom DM, Bangs JD. Glycosilphosphatidylinositol-dependent secretory transport in Trypanosoma brucei. Biochem J 1998;335: 681-689.
26. Ashford RW, Bates PA. Leishmaniasis in the Old World. In Cox FEG, Krier JP, Wakelin D (Eds.), Microbiology and Microbial Infections, vol. 15. Parasitology. London: Arnold, 1998: 215-240.
27. Engel JC, Torres-Garcia C, Hsieh I, Doyle PS, McKerrow JH. Up-regulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi. J Cell Sci 2000;113: 1345-1354.
28. Zhang WW, Charest H, Ghedin E, Matlashewski G. Overexpression of the A2 amastigote-specific protein in Leishmania donovani. Mol Biochem Parasitol 1996;78: 79-90.
29. Prescianotto-Baschong C, Riezman H. Morphology of the yeast endocytic pathway. Mol Biol Cell 1998;9: 173-189.
30. Shahabuddin M, Gayle M, Zieler H, Laughinhouse A. Plasmodium gallinaceum: fluorescent staining of zygotes and ookinetes to study malaria parasites in mosquito. Exp Parasitol 1998;88: 79-84.