An Mr 145000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order

Molecular and Biochemical Parasitology

Volumn 76, Issue 1-2, 1996, Pages 43-56

  Bastin, Philippe ^a,b   Stephan, André ^a   Raper, Jayne ^a   Saint Remy, Jean Marie ^a   Opperdoes, Frederik R ^a   Courtoy, Pierre J ^a  

^a International Institute of Cellular and Molecular Pathology   (Belgium)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Antigen; Cross reactivity; Endocytosis; Kinetoplastida; LDL receptor

Indexed keywords

BODONIDAE; CRITHIDIA LUCILIAE; EUPHORBIA; KINETOPLASTIDA; LEISHMANIA DONOVANI; MAMMALIA; PHYTOMONAS SP.; TRYPANOPLASMA BORRELI; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CONGOLENSE; TRYPANOSOMA EQUIPERDUM; TRYPANOSOMA VIVAX; TRYPANOZOON;

BINDING PROTEIN; LOW DENSITY LIPOPROTEIN; TRYPANOSOMA VACCINE; GLYCOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CROSS REACTION; ENDOCYTOSIS; FLAGELLATE; IMMUNIZATION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; AFFINITY CHROMATOGRAPHY; ANIMAL; BINDING COMPETITION; CHEMISTRY; IMMUNOLOGY; ISOLATION AND PURIFICATION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; BLOTTING, WESTERN; CHROMATOGRAPHY, AFFINITY; CROSS REACTIONS; ENDOCYTOSIS; GLYCOPROTEINS; IMMUNIZATION; KINETOPLASTIDA; MICE; RECEPTORS, LDL;

EID: 0029657966     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(95)02537-5     Document Type: Article

References (53)

1. Molyneux, D.H. and Ashford, R.W. (1983) The Biology of Trypanosoma and Leishmania, Parasites of Man and Domestic Animals, Taylor and Francis Ltd, London.
2. Dransfield, R.D., Williams, B.G. and Brightwell, R. (1991) Control of tsetse flies and trypanosomiasis: myth or reality? Parasitol. Today 7, 287-291.
3. Clayton, C., Hausler, T. and Blattner, J. (1995) Protein trafficking in Kinetoplastid protozoa. Microbiol. Rev., 59, 325-344.
4. Coppens, I., Baudhuin, P., Opperdoes, F.R. and Courtoy, P.J. (1988) Receptors for the host low-density lipoproteins on the hemoflagellate Trypanosoma brucei brucei: purification and involvement in the growth of the parasite. Proc. Natl. Acad. Sci. USA 85, 6753-6757.
5. Coppens, I., Levade, T. and Courtoy, P.J. (1995) Host plasma lipoprotein particles as an essential source of lipids for the bloodstream form of Trypanosoma brucei. J. Biol. Chem 270, 5736-5741.
6. Cross, G. A. M. (1990) Cellular and genetic aspects of antigenic variation in trypanosomes. Ann. Rev. Immunol. 8, 83-110.
7. Pays, E., Van Hamme, L. and Berberof, M. (1994) Genetic controls for the expression of surface antigens in African trypanosomes. Annu. Rev. Microbiol. 48, 25-52.
8. Overath, P., Chaudri, M., Steverding, D. and Ziegelbauer, K. (1994) Invariant surface proteins in Trypanosoma brucei. Parasitol. Today 10, 53-58.
9. Hager, K.M., Pierce, M.A., Moore, D.R., Tytler, E.M., Esko, J.D. and Hajduk, S.L. (1994) Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes. J. Cell Biol. 126, 155-167.
10. Schell, D., Evers, R., Preis, D., Ziegelbauer, K., Kiefer, H., Lottspeich, F., Cornelissen, A.W.C.A. and Overath, P. (1991) A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein gene expression site. EMBO J. 5, 1061-1066.
11. Salmon, D., Geuskens, M., Hanocq, F., Hanocq-Quertier, J., Nolan, D., Ruben, L. and Pays, E. (1994) A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei. Cell 78, 75-86.
12. Ligtenberg, M.J.L., Bitter, W., Kieft, R., Steverding, D., Janssen, H., Calafat, J. and Borst, P. (1994) Reconstitution of a surface transferrin binding complex in insect form Trypanosoma brucei. EMBO J. 13, 2565-2573.
13. Chaudri, M., Steverding, D., Kittelberger, D. and Overath, P. (1994) Expression of a glycosylphosphatidylinositol-anchored Trypanosoma brucei transferrin-binding protein complex in insect cells. Proc. Natl. Acad. Sci. USA 91, 6443-6447.
14. Paindavoine, P., Rolin, S., Van Assel, S., Geuskens, M., Jauniaux, J.C., Dinsart, C., Huet, G. and Pays, E. (1992) A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei. Mol. Cell. Biol. 12, 1218-1225.
15. Schell, D., Stierhof, Y.D. and Overath, P. (1990) Purification and characterization of a tartrate-sensitive acid phosphatase of Trypanosoma brucei. FEBS Lett. 271, 67-70.
16. Ziegelbauer, K. and Overath, P. (1992) Identification of invariant surface glycoproteins in the bloodstream stage of Trypanosoma brucei. J. Biol. Chem. 267, 10797-10803.
17. Ziegelbauer, K., Multhaup, G. and Overath, P. (1992) Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei. J. Biol. Chem. 267, 10797-10803.
18. Lee, M.G.S., Bihain, B.E., Russell, D.G., Deckelbaum, R.J. and Van der Ploeg, L.H.T. (1990) Characterization of a cDNA encoding a cystein-rich cell surface protein located in the flagellar pocket of the protozoan Trypanosoma brucei. Mol. Cell. Biol. 10, 4506-4517.
19. Lee, M.G.S., Russell, D.G., D'Alesandro, P.A. and Van der Ploeg, L.H.T. (1994) Identification of membrane-associated protein in Trypanosoma brucei encoding an internal, EARLRAEE amino acid repeat. J. Biol. Chem. 269, 8408-8415.
20. Bastin, Ph., Coppens, I., Saint-Remy, J.M., Baudhuin, P., Opperdoes, F.R. and Courtoy, P.J. (1994) Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei. Mol. Biochem. Parasitol. 63, 193-202.
21. De Greef, C., Imberechts, H., Matthysen, G., Van Merveinne, N. and Hamers, R. (1989) A gene expressed only in serum-resistant variants of Trypanosoma brucei rhodesiense. Mol. Biochem. Parasitol. 36, 169-176.
22. Opperdoes, F.R., Aarsen, P.N., Van der Meer, C. and Borst, P. (1976) Trypanosoma brucei : an evaluation of salicylhydroxamic acid as trypanocidal drug. Exp. Parasitol. 40, 198-206.
23. Opperdoes, F.R., Nohynkova, E., Van Schaftingen, E., Lambeir A.M., Veenhuis M. and Van Roy, J. (1988) Demonstration of glycosomes (microbodies) in the Bodonid flagellate Trypanoplasma borelli (protozoa, kinetoplastida). Mol. Biochem. Parasitol. 30, 155-164.
24. Zilberstein, D., Blumenfeld, N., Liveanu, V., Gepstein, A., Jaffe, C.L. (1991) Growth at acidic pH induces amastigote stage-specific protein in Leishmania promastigotes. Mol. Biochem. Parasitol. 45, 175-179.
25. Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J. and Klenk, D.C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
26. Coppens, I., Bastin P., Courtoy, P.J., Baudhuin, P. and Opperdoes, F.R. (1991) A rapid method purifies a glycoprotein of Mr 145,000 as the LDL receptor of Trypanosoma brucei brucei. Biochem. Biophys. Res. Commun. 178, 185-191.
27. Coppens, I., Opperdoes, F.R., Courtoy, PJ. and Baudhuin, P. (1987) Receptor-mediated endocytosis in the bloodstream form of Trypanosoma brucei. J. Protozool. 34, 465-473.
28. Langreth, S.G. and Balber, A.E. (1975) Protein uptake and digestion in bloodstream and culture forms of Trypanosoma brucei. J. Protozool. 22, 40-53.
29. Webster, P. (1989) Endocytosis by African trypanosomes. I. Three-dimensional structure of the endocytic organelles in Trypanosoma brucei and in Trypanosoma congolense. Eur. J. Cell Biol. 49, 295-302.
30. Webster, P. and Fish, W. (1989) Endocytosis by African trypanosomes. II. Occurence in different life-cycle stages and intracellular sorting. Eur. J. Cell Biol. 49, 303-310.
31. Burleigh, B.A., Wells, C.W., Clarke, M.W. and Gardiner, P.R. (1993) An integral membrane glycoprotein associated with an endocytic compartment of Trypanosoma vivax: identification and partial characterization. J. Cell Biol. 20, 339-352.
32. Soares, M.J. and de Souza, W. (1991) Endocytosis of gold-labeled proteins and LDL by Trypanosoma cruzi. Parasitol. Res. 77, 461-468.
33. Soares, M.J., Souto-Padron, T. and De Souza, W. (1992) Identification of large prelysosomal compartments in the pathogenic protozoon Trypanosoma cruzi. J. Cell Sci. 102, 157-167.
34. Russell, D.G., Xu S. and Chakroborty, P. (1992) Intracellular trafficking and the parasitophorous vacuole of Leishmania mexicana-infected macrophages. J. Cell Sci. 103, 1193-1210.
35. Brooker, B.E. (1971) The fine structure of Crithidia fasciculata with special reference to the organelles involved in the ingestion and digestion of protein. Z. Zellforsch. 116, 532-563.
36. Lòm, J. (1979) Biology of the trypanosomes and trypanoplasms of fish. In: Biology of the Kinetoplastida, Vol. 2 (Lumsden, W.R. and Evans, D.A., eds.), pp. 269-330. Academic Press, London.
37. Cupers, P., Veithen, A., Kiss, A., Baudhuin, P. and Courtoy P.J. (1994) Clathrin polymerisation is not required for bulk-phase endocytosis in rat fetal fibroblasts. J. Cell Biol. 127, 725-735.
38. Gjoen, T. and Berg, T. (1992) Metabolism of high-density lipoproteins in rainbow trout. Biochim. Biophys. Acta 1125, 8-12.
39. Gillett, M.P.T. and Owen, J.S. (1992) Characteristics of the binding of human and bovine high-density lipoproteins by bloodstream forms of the African trypanosome, Trypanosoma brucei brucei. Biochim. Biophys. Acta, 1123, 239-248.
40. Antoine, J.C. and Prina, E. (1992) Morphology, composition and functions of the endocytotic compartment housing Leishmania amazonensis in infected macrophages. NATO series (Courtoy, P.J., ed.), pp. 381-388.
41. Knight, B.L. and Soutar, A.K. (1982) Degradation by cultured fibroblasts and macrophages of unmodified and 1,2 cyclohexanedione-modified low-density lipoproteins from normal and homozygous familial hypercholesterolemia subjects. Biochem. J. 202, 145-152.
42. VanderHorst, D.J. (1990) Lipid transport function of lipoproteins in flying insects. Biochim. Biophys. Acta 1045, 195-211.
43. Wilson, C., Wardell, M.R., Weisgraber, K.H., Malhey, R.W. and Agard, D.A. (1991) Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 252, 1817-1822.
44. Liu, H., Malhotra, V. and Ryan, R.O. (1991) Displacement of apolipophorin III from the surface of low density lipophorin by human apoprotein A-I. Biochem. Biophys. Res. Commun. 179, 734-740.
45. Herz, J. and Krieger, M. (1994) Structures and functions of multiligand lipopotein receptors-macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63, 601-637.
46. Vickerman, K. and Preston, T.M. (1976) Comparative cell biology of the kinetoplastida flagellates. In: Biology of the Kinetoplastida, Vol. 1 (Lumsden, W.R. and Evans, D.A., eds.), pp. 35-130. Academic Press, London.
47. Coppens, I. and Courtoy, P.J. (1995) Exogeneous and endogeneous sources of sterols in the culture-adapted procyclic trypomastigotes of Trypanosoma brucei. Mol. Biochem. Parasitol. 73, 179-188.
48. Coppens, I., Bastin, Ph., Opperdoes, F.R., Baudhuin, P. and Courtoy, P.J. (1992) Trypanosoma brucei brucei: antigenie stability of its LDL-receptor and immunological cross-reactivity with the LDL-receptor of the mammalian host. Exp. Parasitol. 74, 77-86.
49. Fitzsimmons, C., Bush, R., Hele, D., Godliman, C., Gherardi, E. and Bowier, D.E. (1995) Measurement of the absolute number of functioning low-density lipoprotein receptors in vivo using a monoclonal antibody. Biochem J. 305, 897-904.
50. Ziegelbauer, K. and Overath, P. (1993) Organisation of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei. Infect. Immun. 61, 4540-4545.
51. Rovis, L., Musoke, A.J. and Moloo, S.K. (1984) Failure of trypanosomal membrane antigens to induce protection against tsetse-transmitted Trypanosoma vivax or T. brucei in goats and rabbits. Acta Trop. 41, 227-236.
52. Hobbs, M.R. and Boothroyd, J.C. (1991) An expression-site associated gene family of trypanosomes is expressed in vivo and shows homology to a variant surface glycoprotein gene. Mol. Biochem. Parasitol. 43, 1-16.
53. Olenick, J.G., Wolff, R., Nauman, R.K. and McLaughlin J. (1988). A flagellar pocket membrane fraction from Trypanosoma brucei rhodesiense: immunogold localization and nonvariant immunoprotection. Infect. Immun. 56, 92-98.