Proteophosphoglycans of Leishmania

Parasitology Today

Volumn 16, Issue 11, 2000, Pages 489-497

  Ilg, T ^a  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ANTILEISHMANIAL AGENT; PROTEOGLYCAN;

AMASTIGOTE; BIOSYNTHESIS; CHEMICAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; GENE EXPRESSION; GENETICS; GLYCOSYLATION; LEISHMANIA; PHOSPHORYLATION; PROMASTIGOTE; REVIEW;

EID: 0034333073     PISSN: 01694758     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-4758(00)01791-9     Document Type: Review

References (64)

1. The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes
2. Glycoconjugates in Leishmania infectivity
3. Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite
4. Biosynthesis of protein-linked oligosaccharides in trypanosomatid flagellates
5. A unique, terminally glucosylated oligosaccharide is a common feature on Leishmania cell surfaces
6. Effect of tunicamycin on the extracellular acid phosphatase of Leishmania donovani promastigotes
7. Acid protease activity of a major surface glycoprotein (gp63) from Leishmania mexicana promastigotes
8. N-glycosylation as a biochemical basis for virulence in Leishmania
9. An investigation into the significance of the N-linked oligosaccharides of Leishmania gp63
10. A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways
11. Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI): protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins
12. Identification, characterization and genomic cloning of a O-linked N-acetylglucosamine-containing cytoplasmic Leishmania glycoprotein
13. O- and N-glycosylation of the Leishmania mexicana-secreted acid phosphatase. Characterization of a new class of Ser(P)-linked glycans
14. Purification, partial characterization and immunolocalization of a proteophosphoglycan secreted by Leishmania mexicana amastigotes
15. Purification and structural characterization of a filamentous, mucin-like proteophosphoglycan secreted by Leishmania parasites
16. Identification and partial characterization of an extracellular acid phosphatase activity of Leishmania donovani promastigotes
17. Comparison of extracellular acid phosphatases from various isolates of Leishmania
18. Leishmania donovani: immunochemical localization and secretory mechanism of soluble acid phosphatase
19. Golgi-mediated post-translational processing of secretory acid phosphatase by Leishmania donovani promastigotes
20. Lipophosphoglycan and secreted acid phosphatase of Leishmania tropica share species-specific epitopes
21. Monoclonal antibodies to Leishmania mexicana promastigote antigens. I. Secreted acid phosphatase and other proteins share epitopes with lipophosphoglycan
22. Secreted acid phosphatase of Leishmania mexicana: a filamentous phosphoglycoprotein polymer
23. Monoclonal antibodies directed against Leishmania secreted acid phosphatase and lipophosphoglycan. Partial characterization of private and public epitopes
24. Characterization of a novel GDP-mannose:serine-protein mannose-1-phosphotransferase from Leishmania mexicana
25. Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase
26. Characterization of polymer release from the flagellar pocket of Leishmania mexicana promastigotes
27. Structure of a filamentous phosphoglycoprotein polymer: the secreted acid phosphatase of Leishmania mexicana
28. Mucin-like proteophosphoglycans from the protozoan parasite Leishmania
29. Phosphoglycosylation of a secreted acid phosphatase from Leishmania donovani
30. A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host
31. Leishmania: immunochemical comparison of the secretory (extracellular) acid phosphatases from various species
32. Molecular cloning and characterization of a novel repeat-containing L. major gene, ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchor
33. Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three-dimensional networks that obstruct the digestive tract of infected sandfly vectors
34. Ultrastructural biology of Leishmania (Viannia) panamensis (=Leishmania braziliensis panamensis) in Lutzomyia gomezi (Diptera: Psychodidae): a natural host-parasite association
35. Development of Leishmania major in Phlebotomus duboscqi and Sergentomyia schwetzi (Diptera: Psychodidae)
36. Biology of Leishmania in phlebotomine sandflies
37. Modification of sand fly biting behavior by Leishmania leads to increased parasite transmission
38. The method of feeding of Phlebotomus argentipes with relation to its bearing on the transmission of Kala-Azar
39. Released glycoconjugate of indigenous Leishmania major enhances survival of a foreign L. major in Phlebotomus papatasi
40. The role of phosphoglycans in Leishmania-sandfly interactions
41. Leishmania major proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function
42. Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and parasite surface antigen 2
43. Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana
44. Structure of Leishmania mexicana lipophosphoglycan
45. Stage-specific proteophosphoglycan from Leishmania mexicana amastigotes. Structural characterization of novel mono-, di-, and triphosphorylated phosphodiester-linked oligosaccharides
46. Proteophosphoglycans of Leishmania mexicana. Identification, purification, structural and ultrastructural characterization of the secreted promastigote proteophosphoglycan pPPG2, a stage-specific glycoisoform of amastigote aPPG
47. Proteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes
48. Proteophosphoglycan, a major secreted product of intracellular Leishmania mexicana amastigotes, is a poor B-cell antigen and does not elicit a specific conventional CD41 T-cell response
49. Antigen presentation by macrophages harboring intravesicular pathogens
50. Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages
51. Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH
52. Secreted proteophosphoglycan of Leishmania mexicana amastigotes activates complement by triggering the mannan binding lectin pathway
53. Endocytosis and secretion in trypanosomatid parasites - tumultuous traffic in a pocket
54. Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania
55. Designing glycoconjugate biosynthesis for an insidious intent: phosphoglycan assembly in Leishmania parasites
56. Biosynthesis of Leishmania lipophosphoglycan: solubilization and partial characterization of the initiating mannosylphosphoryltransferase
57. Synthetic phospho-oligosaccharide fragments of lipophosphoglycan as acceptors for Leishmania major alpha-d-mannosylphosphate transferase
58. Leishmania donovani has distinct mannosylphosphoryltransferases for the initiation and elongation phases of lipophosphoglycan repeating unit biosynthesis
59. The cysteine proteinase gene cprG in Dictyostelium discoideum has a Ser-rich domain that contains GlcNAc-1-P
60. Structural characterization of novel oligosaccharides of cell surface glycoproteins of Trypanosoma cruzi
61. The major surface antigens of Entamoeba histolytica trophozoites are GPI-anchored proteophosphoglycans
62. Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana
63. Metacyclogenesis in Leishmania promastigotes
64. Biological roles of oligosaccharides: all of the theories are correct