The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research

Journal of Cell Science

Volumn 112, Issue 17, 1999, Pages 2799-2809

  Ferguson, Michael A J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPHOSPHOLIPID; GLYCOSYLPHOSPHATIDYLINOSITOL; VARIANT SURFACE GLYCOPROTEIN;

ANTIPROTOZOAL ACTIVITY; BIOSYNTHESIS; CELL SURFACE; CYTOLOGY; ENZYME SPECIFICITY; EUKARYOTE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA;

EUKARYOTA; INVERTEBRATA; MAMMALIA; PROTOZOA; TRYPANOSOMA;

EID: 0032820595     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (138)

1. Almeida, I. C., Ferguson, M. A. J., Schenkman, S. and Travassos, L. R. (1994). Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi. Biochem. J. 304, 793-802.
2. Armstrong, C., Schubert, J., Ueda, E., Knez, J. J., Gelperin, D., Hirose, S., Silber, R., Hollan, S., Schnidt, R. E. and Medof, M. E. (1992). Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in the assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1-murine lymphoma mutants. J. Biol. Chem. 267, 25347-25351.
3. Azzouz, N., Striepen, B., Gerold, P., Capdeville, Y. and Schwarz, R. T. (1995). Glycosylinositol-phosphoceramide in the free-living protozoan Paramecium primaurelia: modification of core glycans by mannosyl phosphate. EMBO J. 14, 4422-4433.
4. Baeschlin, D. K., Chaperon, A. R., Charbonneau, V., Green, L. G., Ley, S. V., Lücking, U. and Walther, E. (1998). Rapid assembly of oligosaccharides: total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei. Angew. Chem. Int. Ed. 37, 3423-3428.
5. Benghezal, M., Benachour, A., Rusconi, S., Aebi, M. and Conzelmann, A. (1996). Yeast Gpi8p is essential for GPI anchor attachment onto proteins. EMBO J. 15, 6575-6583.
6. Bessler, M., Mason, P. J., Hillmen, P., Miyata, T., Yamada, N., Takeda, J., Luzzatto, L. and Kinoshita, T. (1994). Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO J. 13, 110-117.
7. Blum, M. L., Down, J. A., Gurnett, A. M., Carrington, M., Turner, M. J. and Wiley, D. C. (1993). A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature 362, 603-609.
8. Boothroyd, J. C., Cross, G. A. M., Hoeijmakers, J. H. and Borst, P. (1980). A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic 'tail' absent from purified glycoprotein. Nature 288, 624-626.
9. Brittingham, A. and Mosser, D. M. (1996). Exploitation of the complement system by Leishmania promastigotes. Parasitol. Today 12, 444-447.
10. Brown, D. A. and Rose, J. K. (1992). Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68, 533-544.
11. Brown, D. A. and London, E. (1997). Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? Biochem. Biophys. Res. Commun. 240, 1-7.
12. Brown, D. A. and London, E. (1998). Structure and origin of lipid ordered domains in biological membranes. J. Membr. Biol. 164, 103-114.
13. Brown, R. E. (1998). Sphingolipid organisation in biomembranes: what physical studies of model membranes reveal. J. Cell Sci. 111, 1-9.
14. Brunschwig, E. B., Trefzer, U. and Tykocinski, M. L. (1995). Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain costimulator function. J. Immunol. 155, 5498-5505.
15. Campbell, A. S. and Fraser-Reid, B. (1995). First synthesis of a fully phosphorylated GPI membrane anchor: rat brain Thy-1. J. Am. Chem. Soc. 117, 10387-10388.
16. Canivenc-Gansel, E., Imhof, I., Reggiori, F., Burda, P., Conzelmann, A. and Benachour, A. (1998). GPI anchor biosynthesis in yeast: phosphoethanolamine is attached to the alpha 1,4-linked mannose of the complete precursor glycophospholipid. Glycobiology 8, 761-770.
17. Cardoso de Almeida, M. L. and Turner, M. J. (1983). The membrane form of variant surface glycoproteins of Trypanosoma brucei. Nature 302, 349-352.
18. Carmargo, M. M., Almeida, I. C., Pereira, M. E. S., Ferguson, M. A. J., Travassos, L. R. and Gazzinelli, R. T. (1997). GPI-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of pro-inflammatory cytokines by macrophages. J. Immunol. 158, 5890-5901.
19. Carreira, J. C., Jones, C., Wait, R., Previato, J. O. and Mendonca-Previato, L. (1996). Structural variations in the glycoinositolphospholipids of different strains of Trypanosoma cruzi. Glycoconj. J. 13, 955-966.
20. Chen, R., Walter, E., Parker, G., Lapurga, J., Millan, J., Ikehara, Y., Udenfriend, S. and Medof, M. (1998). Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation. Proc. Nat. Acad. Sci. USA 95, 9512-9517.
21. Cinek, T. and Horejsí, V. (1992). The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases. J. Immunol. 149, 2262-2270.
22. Costello, L. C. and Orlean, P. (1992). Inositol acylation of a potential glycosyl phosphoinositol anchor precursor from yeast requires acyl coenzyme A. J. Biol. Chem. 267, 8599-8603.
23. Cross, G. A. M. (1975). Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology 71, 393-417.
24. Crossman, A., Brimacombe, J. S. and Ferguson, M. A. J. (1997). Parasite glycoconjugates. Part 7. Synthesis of further substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors. J. Chem. Soc. Perkin Trans. 1, 2769-2774.
25. Dan, N. and Lehrman, M. A. (1997). Oligomerization of hamster UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase, an enzyme with multiple transmembrane spans. J. Biol. Chem. 272, 14214-14219.
26. Doerrler, W. T., Ye, J., Falck, J. R. and Lehrman, M. A. (1996). Acylation of glucosaminyl phosphatidylinositol revisited. J. Biol. Chem. 271, 27031-27038.
27. Edidin, M. (1997). Lipid microdomains in cell surface membranes. Curr. Opin. Struct. Biol. 7, 528-532.
28. Ferguson, M. A. J., Halder, K. and Cross, G. A. M. (1985a). Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristylglycerol membrane anchor at its COOH-terminus. J. Biol. Chem. 260, 4963-4968.
29. Ferguson, M. A. J., Low, M. G. and Cross, G. A. M. (1985b). Glycosyl-sn-1,2-dimyristoylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein. J. Biol. Chem. 260, 14547-14555.
30. Ferguson, M. A. J., Homans, S. W., Dwek, R. A. and Rademacher, T. W. (1988). Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane. Science 239, 753-759.
31. Ferguson, M. A. J. (1997). The surface glycoconjugates of trypanosomatid parasites. Philos. Trans. R. Soc. London B 352, 1295-1302.
32. Fiedler, K., Kobayashi, T., Kurzchalia, T. and Simons, K. (1993). Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells. Biochemistry 32, 6365-6373.
33. Friedrichson, T. and Kurzchalia, T. V. (1998). Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature 394, 802-805.
34. Futerman, A., Low, M., Ackermann, K., Sherman, W. and Silman, I. (1985). Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase. Biochem. Biophys. Res. Commun. 129, 312-317.
35. Gazzinelli, R. T., Carmargo, M. M., Almeida, I. C., Morita, Y. S., Acosta-Serrano, A., Hieny, S., Englund, P. T., Ferguson, M. A. J., Travassos, L. R. and Sher, A. (1997). Identification and characterisation of protozoan products that trigger the synthesis of IL-12 by inflammatory macrophages. Chem. Immunol. 68, 136-152.
36. Gerold, P., Dieckmann-Schupper, A. and Schwarz, R. T. (1994). Glycosylphosphatidylinositols synthesized by asexual erythrocytic stages of the malarial parasite, Plasmodium falciparum: candidates for plasmodial glycosylphosphatidylinositol membrane anchor precursors and pathogenicity factors. J. Biol. Chem. 269, 2597-25606.
37. Gerold, P., Schofield, L., Blackman, M. J., Holder, A. A. and Schwarz, R. T. (1996). Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum. Mol. Biochem. Parasitol. 75, 131-143.
38. Gigg, R. and Gigg, J. (1997). Synthesis of glycosylphosphatidylinositol anchors. In Glycopeptides and related compounds: synthesis, analysis and applications (eds D. G. Large and D. Warren), pp. 327-392.
39. Güther, M. L. S., Masterson, W. J. and Ferguson, M. A. J. (1994). The effects of phenylmethylsulphonyl fluoride on inositol-acylation and fatty acid remodelling in African trypanosomes. J. Biol. Chem. 269, 18694-18701.
40. Güther, M. L. S. and Ferguson, M. A. J. (1995). The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei. EMBO J. 14, 3080-3093.
41. Hamburger, D., Egerton, M. and Riezman, H. (1995). Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins. J. Cell Biol. 129, 629-639.
42. Harder, T. and Simons, K. (1997). Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr. Opin. Cell Biol. 9, 534-542.
43. Harder, T., Scheiffele, P., Verkade, P. and Simons, K. (1998). Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141, 929-942.
44. Harrison, P. T., Campbell, I. W. and Allen, J. M. (1997). Use of GPI-anchored proteins to study biomolecular interactions by surface plasmon resonance. FEBS Lett. 422, 301-306.
45. Hirose, S., Prince, G. M., Sevlever, D., Ravi, L., Rosenberry, T. L., Ueda, E. and Medof, M. E. (1992). Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine. J. Biol. Chem. 267, 16968-16974.
46. Holder, A. A. (1983). Carbohydrate is linked through ethanolamine to the C-terminal amino acid of Trypanosoma brucei variant surface glycoprotein. Biochem. J. 209, 261-262.
47. Homans, S. W., Ferguson, M. A. J., Dwek, R. A., Rademacher, T. W., Anand, R. and Williams, A. F. (1988). Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein. Nature 333, 269-272.
48. Hooper, N. and Turner, A. (1988). Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor. Biochem. J. 250, 865-869.
49. Horejsi, V., Cebecauer, M., Cerny, J., Brdicka, T., Angelisova, P. and Drbal, K. (1998). Signal transduction in leucocytes via GPI-anchored proteins: an experimental artefact or an aspect of immunoreceptor function? Immunol. Lett. 63, 63-73.
50. Ikezawa, H., Yamanegi, M., Taguchi, R., Miyashita, T. and Ohyabu, T. (1976). Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus. I. purification, properties and phosphatase-releasing activity. Biochim. Biophys. Acta 450, 154-164.
51. Ilangumaran, S., Robinson, P. J. and Daniel, C. H. (1996). Transfer of exogeneous glycosylphosphatidylinositol (GPI)-linked molecules to plasma membranes. Trends Cell Biol. 6, 163-167.
52. Jacobson, K. and Dietricht, C. (1999). Looking at lipid rafts? Trends Cell Biol. 9, 87-91.
53. Kenworthy, A. K. and Edidin, M. (1998). Distribution of glycosylphosphatidylinositol-anchored protein at the apical surface of MDCK cells examined at a resolution of <100 Å using imaging fluorescence resonance energy transfer. J. Cell Biol. 142, 69-84.
54. Kinoshita, T., Ohishi, K. and Takeda, J. (1997). GPI-anchor synthesis in mammalian cells: genes, their products, and a deficiency. J. Biochem. 122, 251-257.
55. Koch, F., Thiele, H. G. and Low, M. G. (1986). Release of the rat T cell alloantigen RT-6.2 from cell membranes by phosphatidylinositol-specific phospholipase C. J. Exp. Med. 164, 1338-1343.
56. Kollár, R., Reinhold, B., Petráková, E., Yeh, H., Ashwell, G., Drgonová, J., Kapteyn, J., Klis, F. and Cabib, E. (1997). Architecture of the yeast cell wall. Beta(1→6)-glucan interconnects mannoprotein, beta(1→)3-glucan, and chitin. J. Biol. Chem. 272, 17762-17775.
57. Krakow, J. L., Hereld, D., Bangs, J. D., Hart, G. W. and Englund, P. T. (1986). Identification of a glycolipid precursor of the Trypanosoma brucei variant surface glycoprotein. J. Biol. Chem. 261, 12147-12153.
58. Lederkremer, R. M., Lima, C., Ramirez, M. I., Ferguson, M. A. J., Homans, S. W. and Thomas-Oates, J. E. (1991). Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi epimastigotes. J. Biol. Chem. 266, 23670-23675.
59. Lee, J. D., Kravchenko, V., Kirkland, T. N., Han, J., Mackman, N., Moriarty, A., Leturcq, D., Tobias, P. S. and Ulevitch, R. J. (1993). Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin. Proc. Nat. Acad. Sci. USA 90, 9930-9934.
60. Leidich, S., Drapp, D. and Orlean, P. (1994). A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. J. Biol. Chem. 269, 10193-10196.
61. Leidich, S., Kostova, Z., Latek, R., Costello, L., Drapp, D., Gray, W., Fassler, J. and Orlean, P. (1995). Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminylphosphatidylinositol. Cloning of the GPI2 gene. J. Biol. Chem. 270, 13029-13035.
62. Lin, A. Y., Devaux, B., Green, A., Sagerstrom, C., Elliott, J. F. and Davis, M. M. (1990). Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science 249, 677-679.
63. Lisanti, M. P., Caras, I. W., Gilbert, T., Hanzel, D. and Rodriguez-Boulan, E. (1990). Vectorial apical delivery and slow endocytosis of a glycolipid-anchored fusion protein in transfected MDCK cells. Proc. Nat. Acad. Sci. USA 87, 7419-7423.
64. Low, M. and Finean, J. (1977). Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C. Biochem J. 167, 281-284.
65. Low, M. and Finean, J. (1978). Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C. Biochim. Biophys. Acta 508, 565-570.
66. Low, M. G. and Zilversmit, D. B. (1980). Role of phosphatidylinositol in attachment of alkaline phosphatase to membranes. Biochemistry 19, 3913-3918.
67. Lu, C., Montijn, R., Brown, J., Klis, F., Kurjan, J., Bussey, H. and Lipke, P. (1995). Glycosyl phosphatidylinositol-dependent cross-linking of alpha-agglutinin and beta 1,6-glucan in the Saccharomyces cerevisiae cell wall. J. Cell Biol. 128, 333-340.
68. Manger, I., Hehl, A. and Boothroyd, J. (1998). The surface of Toxoplasma tachyzoites is dominated by a family of glycosylphosphatidylinositol-anchored antigens related to SAG1. Infect. Immun. 66, 2237-2244.
69. Massagué, J. (1996). Neurotrophic factors. Crossing receptor boundaries. Nature 382, 29-30.
70. Masterson, W. J., Doering, T. L., Hart, G. W. and Englund, P. T. (1989). A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the Trypanosoma brucei variant surface glycoprotein. Cell 56, 793-800.
71. Masterson, W. J., Raper, J., Doering, T. L., Hart, G. W. and Englund, P. T. (1990). Fatty acid remodelling: a novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors. Cell 62, 73-80.
72. Mayor, A., Menon, A. K. and Cross, G. A. M. (1990a). Glycolipid precursors for the membrane anchor of Trypanosoma brucei variant surface glycoproteins. J. Biol. Chem. 265, 6174-6181.
73. Mayor, S., Menon, A. K., Cross, G. A. M., Ferguson, M. A. J., Dwek, R. A. and Rademacher, T. (1990b). Glycolipid precursors for the membrane anchor of Trypanosoma brucei variant surface glycoproteins. J. Biol. Chem. 265, 6164-6173.
74. McConville, M. J., Turco, S. J., Ferguson, M. A. J. and Sacks, D. L. (1992). Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage. EMBO J. 11, 3593-3600.
75. McConville, M. J. and Ferguson, M. A. J. (1993). The structure, biosynthesis and function of glycosylated-phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem. J. 294, 305-324.
76. McConville, M. J., Schnur, L. F., Jaffe, C. and Schneider, P. (1995). Structure of Leishmania lipophosphoglycan: inter-and intra-specific polymorphism in Old World species. Biochem. J. 310, 807-818.
77. McHugh, R. S., Ahmed, S. N., Wang, Y. C., Sell, K. W. and Selvaraj, P. (1995). Construction, purification, and functional incorporation on tumor cells of glycolipid-anchored human B7-1 (CD80). Proc. Nat. Acad. Sci. USA 92, 8059-8063.
78. Medof, M. E., Nagarajan, S. and Tykocinski, M. L. (1996). Cell-surface engineering with GPI-anchored proteins. FASEB J. 10, 574-586.
79. Moran, P. and Caras, I. W. (1994). Requirements for glycosylphosphatidylinositol attachment are similar but not identical in mammalian cells and parasitical protozoa. J. Cell Biol. 125, 333-343.
80. Murakata, C. and Ogawa, T. (1992). Stereoselective total synthesis of the glycosylphosphatidylinositol (GPI). anchor of Trypanosoma brucei. Carbohydr. Res. 234, 95-104.
81. Nakamura, N., Inoue, N., Watanabe, R., Takahashi, M., Takeda, J., Stevens, V. L. and Kinoshita, T. (1997). Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase. J. Biol. Chem. 272, 15834-15840.
82. Pimenta, P. F., Turco, S. J., McConville, M. J., Lawyer, P. G., Perkins, P. V. and Sacks, D. L. (1992). Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut. Science 256, 1812-1815.
83. Pimenta, P. F., Saraiva, E. M. B., Rowton, E., Modi, G. B., Garraway, L. A., Beverley, S. M., Turco, S. J. and Sacks, D. L. (1994). Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan. Proc. Nat. Acad. Sci. USA 91, 9155-9159.
84. Previato, J. O., Gorin, P. A. J., Mazurek, M., Xavier, M. T., Fournet, B., Wieruszesk, J. M. and Mendonca-Previato, L. (1990). Primary structure of the oligosaccharide chain of lipopeptidophosphoglycan of epimastigote forms of Trypanosoma cruzi. J. Biol. Chem. 265, 2518-2526.
85. Previato, J. O., Jones, C., Goncalves, L. P. B., Wait, R., Travassos, L. R. and Medonca-Previato, L. (1994). O-Glycosidically linked N-acetylglucosamine-bound oligosaccharides from glycoproteins of Trypanosoma cruzi. Biochem. J. 301, 151-159.
86. Previato, J. O., Jones, C., Xavier, M. T., Wait, R., Travassos, L. R., Parodi, A. J. and Mendoça-Previato, L. (1995). Structural characterisation of the major glycosylphosphatidylinositol membrane anchored glycoprotein from epimastigote forms of Trypanosoma cruzi strains. J. Biol. Chem. 270, 7241-7250.
87. Proudfoot, L., O'Donnell, C. A. and Liew, F. Y. (1995). Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages. Eur. J. Immunol. 25, 745-750.
88. Proudfoot, L., Nikolaev, A. V., Ferguson, M. A. J., Brimacombe, J. S. and Liew, F. Y. (1996). Regulation of the expression of nitric oxide synthase and leishmanocidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc. Nat. Acad. Sci. USA 93, 10984-10989.
89. Puoti, A. and Conzelmann, A. (1993). Characterization of abnormal free glycosylphosphatidylinositols accumulating in mutant lymphoma cells of classes B, E, F and H. J. Biol. Chem. 268, 7215-7224.
90. Ralton, J. E. and McConville, M. J. (1998). Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling. J. Biol. Chem. 273, 4245-4257.
91. Reggiori, F., Canivenc-Gansel, E. and Conzelmann, A. (1997). Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. EMBO J. 16, 3506-3518.
92. Richier, P., Arpagaus, M. and Toutant, J.-P. (1992). Glycolipid-anchored acetylcholinesterasees from rabbit lymphocytes and erythrocytes differ in their sensitivity to phosphatidylinositol-specific phospholipase C. Biochim. Biophys. Acta 1112, 83-88.
93. Roberts, W. and Rosenberry, T. (1985). Identification of covalently attached fatty acids in the hydrophobic membrane-binding domain of human erythrocyte acetylcholinesterase. Biochem. Biophys. Res. Commun. 133, 621-627.
94. Roberts, W. L., Myher, J. J., Kuksis, A., Low, M. G. and Rosenberry, T. L. (1988a). Lipid analysis of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase. J. Biol. Chem. 263, 18766-18775.
95. Roberts, W. L., Santikarn, S., Reinhold, V. N. and Rosenberry, T. L. (1988b). Structural characterization of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase by fast atom bombardment mass spectrometry. J. Biol. Chem. 263, 18776-18784.
96. Robinson, P., Millrain, M., Antoniou, J., Simpson, E. and Mellor, A. (1989). A glycophospholipid anchor is required for Qa-2-mediated T cell activation. Nature 342, 85-87.
97. Robinson, P. (1997). Signal transduction via GPI-anchored membrane proteins. Adv. Exp. Med. Biol. 419, 365-370.
98. Ross, R. and Thomson, D. (1910). A case of sleeping sickness studied by precise enumerative methods: regular periodical increase of the parasites disclosed. Proc. R. Soc. London 82, 411-425.
99. Routier, F. H., da Silveira, E. X., Wait, R., Jones, C., Previato, J. O. and Mendonca-Previato, L. (1995). Chemical characterisation of glycosylinositolphospholipids of Herpetomonas samuelpessoai. Mol. Biochem. Parasitol. 69, 61-69.
100. Sacks, D. L., Pimenta, P. F., McConville, M. J., Schneider, P. and Turco, S. J. (1995). Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan. J. Exp. Med. 181, 685-697.
101. Schenkman, S., Eichinger, D., Pereira, M. A. and Nussenzweig, V. (1994). Structural and functional properties of Trypanosoma trans-sialidase. Annu. Rev. Microbiol. 48, 499-523.
102. Schneider, P. and Ferguson, M. A. J. (1995). Microscale analysis of glycosylphosphatidylinositol structures. Meth. Enzymol. 250, 614-630.
103. Schofield, L. and Hackett, F. (1993). Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites. J. Exp. Med. 177, 145-153.
104. Schroeder, R., Ahmed, S., Zhu, Y., London, E. and Brown, D. (1998). Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains. J. Biol. Chem. 273, 1150-1157.
105. Serrano, A. A., Schenkman, S., Yoshida, N., Mehlert, A., Richardson, J. M. and Ferguson, M. A. J. (1995). The lipid structure of the GPI-anchored mucin-like sialic acid acceptors of Trypanosoma cruzi changes during parasite differentiation from epimastigotes to infective metacyclic trypomastigote forms. J. Biol. Chem. 270, 27244-27253.
106. Sharma, D. K., Smith, T. K., Crossman, A., Brimacombe, J. S. and Ferguson, M. A. J. (1997). The substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells. Biochem. J. 328, 171-177.
107. Sharma, D. K., Smith, T. K., Weller, C. T., Crossman, A., Brimacombe, J. S. and Ferguson, M. A. J. (1999). Differences between the trypanosome and human GlcNAc-PI de-N-acetylases of glycosylphosphatidylinositol membrane anchor biosynthesis. Glycobiology 9, 415-422.
108. Shenoy-Scaria, A. M., Gauen, L. K., Kwong, J., Shaw, A. S. and Lublin, D. M. (1993). Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Mol. Cell. Biol. 13, 6385-6392.
109. Simons, K. and van Meer, G. (1988). Lipid sorting in epithelial cells. Biochemistry 27, 6197-6202.
110. Simons, K. and Ikonen, E. (1997). Functional rafts in cell membranes. Nature 387, 569-572.
111. Smith, T. K., Milne, F., Sharma, D. K., Crossman, A., Brimacombe, J. S. and Ferguson, M. A. J. (1997a). Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major. Biochem. J. 326, 393-400.
112. Smith, T. K., Sharma, D. K., Crossman, A., Dix, A., Brimacombe, J. S. and Ferguson, M. A. J. (1997b). Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues. EMBO J. 16, 6667-6675.
113. Stahl, N. and Yancopoulos, G. D. (1993). The alphas, betas, and kinases of cytokine receptor complexes. Cell 74, 587-590.
114. Stefanová, I., Horejsí, V., Ansotegui, I. J., Knapp, W. and Stockinger, H. (1991). GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254, 1016-1019.
115. Stevens, V. L. and Tang, J. (1997). Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. J. Biol. Chem. 272, 18020-18025.
116. Stockinger, H. (1997). Interaction of GPI-anchored cell surface proteins and complement receptor type 3. Exp. Clin. Immunogenet. 14, 5-10.
117. Sütterlin, C., Horvath, A., Gerold, P., Schwarz, R., Wang, Y., Dreyfuss, M. and Riezman, H. (1997). Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis. EMBO J. 16, 6374-6383.
118. Sütterlin, C., Escribano, M., Gerold, P., Maeda, Y., Mazon, M., Kinoshita, T., Schwarz, R. and Riezman, H. (1998). Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. Biochem. J. 332, 153-159.
119. Tachado, S. D., Gerold, P., Schwarz, R., Novakovic, S., McConville, M. and Schofield, L. (1997). Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc. Nat. Acad. Sci. USA 94, 4022-4027.
120. Taguchi, R., Asahi, Y. and Ikezawa, H. (1980). Purification and properties of phosphatidylinositol-specific phospholipase C of Bacillus. Biochim. Biophys. Acta 619, 48-57.
121. Taguchi, R., Asahi, Y. and Ikezawa, H. (1985). Ectoenzyme release from rat liver and kidney by phosphatidylinositol-specific phospholipase C. J. Biochem. 97, 911-921.
122. Tailler, D., Ferrieres, V., Pekari, K. and Schmidt, R. R. (1999). Synthesis of the glycosyl phosphatidylinositol anchor of rat brain Thy-1. Tetrahedron Lett. 40, 679-682.
123. Takahashi, M., Takeda, J., Hirose, S., Hyman, R., Inoue, N., Miyata, T., Ueda, E., Kitani, T., Medof, M. E. and Kinoshita, T. (1993). Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria. J. Exp. Med. 177, 517-521.
124. Tarutani, M., Itami, S., Okabe, M., Ikawa, M., Tezuka, T., Yoshikawa, K., Kinoshita, T. and Takeda, J. (1997). Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc. Nat. Acad. Sci. USA 94, 7400-7405.
125. Tomavo, S., Dubrametz, J.-F. and Schwarz, R. T. (1992). Biosynthesis of glycolipid precursors for glycosylphosphatidylinositol membrane anchors in a Toxoplasma gondii cell-free system. J. Biol. Chem. 267, 21446-21458.
126. Treumann, A., Lifely, M. R., Schneider, P. and Ferguson, M. A. J. (1995). Primary structure of CD52. J. Biol. Chem. 270, 6088-6099.
127. Treumann, A., Güther, M. L. S., Schneider, P. and Ferguson, M. A. J. (1998). Analysis of the carbohydrate and lipid components of glycosylphosphatidylinositol structures. In Methods in Molecular Biology, vol. 76. (ed. E. Hounsell), pp. 213-235. Humana Press.
128. Tse, A. G. D., Barclay, N., Watts, A. and Williams, A. F. (1985). A glycophospholipid tail at the carboxyl terminus of the Thy-1 glycoprotein of neurons and thymocytes. Science 230, 1003-1008.
129. Turco, S. J. and Descoteaux, A. (1992). The lipophosphoglycan of Leishmania parasites. Annu. Rev. Microbiol. 46, 65-94.
130. Udenfriend, S. and Kodukula, K. (1995). Prediction of omega site in nascent precursor of glycosylphosphatidylinositol protein. Meth. Enzymol. 250, 571-582.
131. Varma, R. and Mayor, S. (1998). GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394, 798-801.
132. Vickerman, K. and Luckins, A. G. (1969). Localisation of variable antigens in the surface coat of Trypanosoma brucei using ferritin-conjugated antibody Nature 224, 1125-1127.
133. Vidugiriene, J. and Menon, A. K. (1993). Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer. J. Cell Biol. 121, 987-996.
134. Watanabe, R., Inoue, N., Westfall, B., Taron, C., Orlean, P., Takeda, J. and Kinoshita, T. (1998). The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPII. EMBO J. 17, 877-885.
135. Wong, Y. W. and Low, M. G. (1992). Phospholipase resistance of the glycosyl-phosphatidylinositol membrane anchor on human alkaline phosphatase. Clin. Chem. 38, 2517-2525.
136. Yang, R.-B., Mark, M. R., Gray, A., Huang, A., Xie, M. H., Zhang, M., Goddard, A., Wood, W. I., Gurney, A. L. and Godowski, P. J. (1998). Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284-288.
137. Zamze, S. E., Ferguson, M. A. J., Collins, R., Dwek, R. A. and Rademacher, T. W. (1988). Characterization of the cross-reacting determinant (CRD) of the glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein. Eur. J. Biochem. 176, 527-534.
138. Zitzmann, N. and Ferguson, M. A. J. (1999). Analysis of the carbohydrate components of glycosylphosphatidylinositol structures using fluorescent labelling. In Methods in Molecular Biology, vol. 116 (ed. M. H. Gelb), pp. 73-89. Humana Press.