Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae

EMBO Journal

Volumn 18, Issue 9, 1999, Pages 2342-2351

  Kündig, Christoph ^a   Haimeur, Anass ^a   Légaré, Danielle ^a   Papadopoulou, Barbara ^a   Ouellette, Marc ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Biopterin; Drug resistance; Folate transport; Leishmania; Methotrexate

Indexed keywords

FOLIC ACID; GREEN FLUORESCENT PROTEIN; METHOTREXATE; PTERIDINE DERIVATIVE; RNA;

ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CULTURE MEDIUM; DRUG RESISTANCE; DRUG TRANSPORT; GENE ISOLATION; LEISHMANIA; MOLECULAR CLONING; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PARASITE; PRIORITY JOURNAL; PROTOZOON;

ANIMALIA; LEISHMANIA; LEISHMANIA TARENTOLAE; PROTOZOA;

EID: 0242698082     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.9.2342     Document Type: Article

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