Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 16, 2000, Pages 9258-9263

  Späth, Gerald F ^a   Epstein, Linda ^b,d   Leader, Ben ^b   Singer, Steven M ^b,e   Avila, Herbert A ^c   Turco, Salvatore J ^c   Beverley, Stephen M ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d Kinetix Pharmaceuticals Inc   (United States)

^e GEORGETOWN UNIVERSITY   (United States)

Author keywords

Galactofuranose; Glycoconjugates; Macrophages; Trypanosomatid parasites

Indexed keywords

LIPOPHOSPHOGLYCAN; TRANSFERASE; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE DISRUPTION; GLYCOSYLATION; IMMUNOFLUORESCENCE MICROSCOPY; INSECT BITE; LEISHMANIA MAJOR; LEUKOCYTE ADHERENCE; LIFE CYCLE; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE VIRULENCE; PRIORITY JOURNAL; VIRUS REPLICATION; VIRUS TRANSMISSION; WESTERN BLOTTING;

ANIMALS; GLYCOCONJUGATES; GLYCOSPHINGOLIPIDS; GLYCOSYLATION; GLYCOSYLPHOSPHATIDYLINOSITOLS; LEISHMANIA MAJOR; MACROPHAGES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; VIRULENCE;

ANIMALIA; INSECTA; LEISHMANIA MAJOR; MAMMALIA; PHLEBOTOMINAE; PROTOZOA; TRYPANOSOMATIDAE;

EID: 0034255342     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.160257897     Document Type: Article

References (57)

1. WHO Expert Committee (1984) The Leishmaniasis (WHO, Geneva).
2. Turco, S. J. & Descoteaux, A. (1992) Annu. Rev. Microbiol. 46, 65-94.
3. Beverley, S. M. & Turco, S. J. (1998) Trends Microbiol. 6, 35-40.
4. McConville, M. J. & Ferguson, M. A. (1993) Biochem. J. 294, 305-324.
5. Liew, F. Y., Xu, D. & Chan, W. L. (1999) Immunol. Lett. 65, 101-104.
6. Descoteaux, A. & Turco, S. J. (1999) Biochim. Biophys. Acta 1455, 341-352.
7. Ilg, T., Handman, E. & Stierhof, Y. D. (1999) Biochem. Soc. Trans. 27, 518-525.
8. Sacks, D. L., Saraiva, E. M., Rowton, E., Turco, S. J. & Pimenta, P. F. (1994) Parasitology 108, S55-S62.
9. Handman, E., Schnur, L. F., Spithill, T. W. & Mitchell, G. F. (1986) J. Immunol. 137, 3608-3613.
10. Sacks, D. L., Modi, G., Rowton, E., Spath, G., Epstein, L., Turco, S. J. & Beverley, S. M. (2000) Proc. Natl. Acad. Sci. USA 97, 406-411.
11. McConville, M. J. & Homans, S. W. (1992) J. Biol. Chem. 267, 5855-5861.
12. Jaffe, C. L., Perez, L. & Schnur, L. F. (1990) Mol. Biochem. Parasitol. 41, 233-240.
13. Greis, K. D., Turco, S. J., Thomas, J. R., McConville, M. J., Homans, S. W. & Ferguson, M. A. (1992) J. Biol. Chem. 267, 5876-5881.
14. Descoteaux, A., Luo, Y., Turco, S. J. & Beverley, S. M. (1995) Science 269, 1869-1872.
15. Ryan, K. A., Garraway, L. A., Descoteaux, A., Turco, S. J. & Beverley, S. M. (1993) Proc. Natl. Acad. Sci. USA 90, 8609-8613.
16. Huang, C. & Turco, S. J. (1993) J. Biol. Chem. 268, 24060-24066.
17. Cruz, A., Coburn, C. M. & Beverley, S. M. (1991) Proc. Natl. Acad. Sci. USA 88, 7170-7174.
18. Callahan, H. L. & Beverley, S. M. (1991) J. Biol. Chem. 266, 18427-18430.
19. Wiese, M., Ilg, T., Lottspeich, F. & Overath, P. (1995) EMBO J. 14, 1067-1074.
20. Ha, S. D., Schwarz, J. K., Turco, S. J. & Beverley, S. M. (1996) Mol. Biochem. Parasitol. 77, 57-64.
21. Marchand, M., Daoud, S., Titus, R. G., Louis, J. & Boon, T. (1987) Parasite Immunol. 9, 81-92.
22. Kapler, G. M., Coburn, C. M. & Beverley, S. M. (1990) Mol. Cell. Biol. 10, 1084-1094.
23. Titus, R. G., Muller, I., Kimsey, P., Cerny, A., Behin, R., Zinkernagel, R. M. & Louis, J. A. (1991) Eur. J. Immunol. 21, 559-567.
24. Titus, R. G., Gueiros-Filho, F. J., de Freitas, L. A. & Beverley, S. M. (1995) Proc. Natl. Acad. Sci. USA 92, 10267-10271.
25. Titus, R. G., Marchand, M., Boon, T. & Louis, J. A. (1985) Parasite Immunol. 7, 545-555.
26. Racoosin, E. L. & Beverley, S. M. (1997) Exp. Parasitol. 85, 283-295.
27. Tolson, D. L., Turco, S. J. & Pearson, T. W. (1990) Infect. Immun. 58, 3500-3507.
28. de Ibarra, A. A., Howard, J. G. & Snary, D. (1982) Parasitology 85, 523-531.
29. Connell, N. D., Medina-Acosta, E., McMaster, W. R., Bloom, B. R. & Russell, D. G. (1993) Proc. Natl. Acad. Sci. USA 90, 11473-11477.
30. Kahl, L. P. & McMahon-Pratt, D. (1987) J. Immunol. 138, 1587-1595.
31. Ilg, T., Harbecke, D., Wiese, M. & Overath, P. (1993) Eur. J. Biochem. 217, 603-615.
32. Spath, G. F. & Weiss, M. C. (1998) J. Cell Biol. 140, 935-946.
33. Orlandi, P. A., Jr., & Turco, S. J. (1987) J. Biol. Chem. 262, 10384-10391.
34. Wilson, M. E. & Hardin, K. K. (1990) J. Immunol. 144, 4825-4834.
35. Ilg, T., Stierhof, Y. D., Craik, D., Simpson, R., Handman, E. & Bacic, A. (1996) J. Biol. Chem. 271, 21583-21596.
36. Ilg, T., Montgomery, J., Stierhof, Y. D. & Handman, E. (1999) J. Biol. Chem. 274, 31410-31420.
37. Lovelace, J. K. & Gottlieb, M. (1986) Am. J. Trop. Med. Hyg. 35, 1121-1128.
38. Wiese, M., Gorcke, I. & Overath, P. (1999) Mol. Biochem. Parasitol. 102, 325-329.
39. Elhay, M., Kelleher, M., Bacic, A., McConville, M. J., Tolson, D. L., Pearson, T. W. & Handman, E. (1990) Mol. Biochem. Parasitol. 40, 255-267.
40. McConville, M. J., Homans, S. W., Thomas-Oates, J. E., Dell, A. & Bacic, A. (1990) J. Biol. Chem. 265, 7385-7394.
41. King, D. L. & Turco, S. J. (1988) Mol. Biochem. Parasitol. 28, 285-293.
42. Glaser, T. A., Moody, S. F., Handman, E., Bacic, A. & Spithill, T. W. (1991) Mol. Biochem. Parasitol. 45, 337-344.
43. Turco, S. J. & Sacks, D. L. (1991) Mol. Biochem. Parasitol. 45, 91-99.
44. Moody, S. F., Handman, E., McConville, M. J. & Bacic, A. (1993) J. Biol. Chem. 268, 18457-18466.
45. Bahr, V., Stierhof, Y. D., Ilg, T., Demar, M., Quinten, M. & Overath, P. (1993) Mol. Biochem. Parasitol. 58, 107-121.
46. Mottram, J. C., Souza, A. E., Hutchison, J. E., Carter, R., Frame, M. J. & Coombs, G. H. (1996) Proc. Natl. Acad. Sci. USA 93, 6008-6013.
47. Wiese, M. (1998) EMBO J. 17, 2619-2628.
48. Da Silva, R. P., Hall, B. F., Joiner, K. A. & Sacks, D. L. (1989) J. Immunol. 143, 617-622.
49. Mosser, D. M. & Edelson, P. J. (1987) Nature (London) 327, 329-331.
50. de Lederkremer, R. M. & Colli, W. (1995) Glycobiology 5, 547-552.
51. McConville, M. J., Collidge, T. A., Ferguson, M. A. & Schneider, P. (1993) J. Biol. Chem. 268, 15595-15604.
52. Proudfoot, L., Schneider, P., Ferguson, M. A. & McConville, M. J. (1995) Biochem. J. 308, 45-55.
53. Ralton, J. E. & McConville, M. J. (1998) J. Biol. Chem. 273, 4245-4257.
54. Mensa-Wilmot, K., Lebowitz, J. H., K, P., Chang, A. A., McGwire, B. S., Tucker, S. & Morris, J. C. (1994) J. Cell Biol. 124, 935-947.
55. Warburg, A. & Schlein, Y. (1986) Am. J. Trop. Med. Hyg. 35, 926-930.
56. Kelleher, M., Bacic, A. & Handman, E. (1992) Proc. Natl. Acad. Sci. USA 89, 6-10.
57. Falkow, S. (1988) Rev. Infect. Dis. 10, S274-S276.