Signal transduction by cell adhesion receptors and the cytoskeleton: Functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members

Annual Review of Pharmacology and Toxicology

Volumn 42, Issue , 2002, Pages 283-323

  Juliano, R L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Actin; Cell adhesion; Integrins; Receptors; Signaling

Indexed keywords

ACTIN; B CADHERIN; CADHERIN; CD47 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE RECEPTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPHRIN; FOCAL ADHESION KINASE; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN; INTEGRIN; L SELECTIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; NETRIN; P CADHERIN; PADGEM PROTEIN; PLEXIN; PROTEIN CDC42; PROTEIN TYROSINE KINASE; R CADHERIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SELECTIN; SEMAPHORIN; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN;

CELL ADHESION; CELL DIFFERENTIATION; CELL INTERACTION; CELL SURVIVAL; COMPLEX FORMATION; CYTOSKELETON; EXTRACELLULAR MATRIX; HUMAN; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

CADHERINS; CYTOSKELETON; INTEGRINS; MAP KINASE SIGNALING SYSTEM; NEURAL CELL ADHESION MOLECULES; PROTEOGLYCANS; RECEPTORS, CYTOKINE; RHO GTP-BINDING PROTEINS; SELECTINS; SIGNAL TRANSDUCTION;

EID: 0036178447     PISSN: 03621642     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.42.090401.151133     Document Type: Review

References (224)

1. Integrin signaling
2. Cell adhesion: Old and new questions
3. Cadherins and tissue formation: Integrating adhesion and signaling
4. Bidirectional signaling between the cytoskeleton and integrins
5. Interactions between mitogenic stimuli, or, a thousand and one connections
6. Cell adhesion molecules, signal transduction and cell growth
7. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
8. Integrin signaling: Tyrosine phosphorylation events in focal adhesions
9. The immunological synapse: A molecular machine controlling T cell activation
10. T cell activation and the cytoskeleton
11. The role of cell adhesion molecules in synaptic plasticity and memory
12. Signaling by Eph receptors and their ephrin ligands
13. DCC and netrins
14. Semaphorin signaling: A little less per-plexin
15. Integrating the MAP kinase signal into the G1 phase cell cycle machinery
16. Integrins and anoikis
17. Mechanisms and consequences of activation of protein kinase B/Akt
18. The evolution of cell adhesion
19. The molecular architecture of focal adhesions
20. New insights into integrin-ligand interaction
21. The structure of cell-adhesion molecules
22. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
23. Integrins and GTPases: Role in tumor cell growth control, motility, and invasion
24. New aspects of integrin signaling in cancer
25. Structural and functional diversity of cadherin superfamily
26. The molecular structure of cell adhesion molecules
27. The cadherin superfamily: Diversity in form and function
28. A striking organization of a large family of human neural cadherin-like cell adhesion genes
29. Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains
30. Directed actin polymerization is the driving force for epithelial cell-cell adhesion
31. Regulation of cadherin adhesive activity
32. p120 catenin regulates the actin cytoskeleton via Rho family GTPases
33. The (Greek) key to structures of neural adhesion molecules
34. Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily
35. The molecular biology of axon guidance
36. Regulation of cortical structure by the ezrin-radixin-moesin protein family
37. Selectin-carbohydrate interactions and the initiation of the inflammatory response
38. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration
39. New discoveries with mice mutant in endothelial and platelet selectins
40. Selectin ligands: Will the real ones please stand up?
41. The biology of P-selectin glycoprotein ligand-1: Its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction
42. The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: Receptor positioning in microvilli does not require interaction with alpha-actinin
43. Signal transduction by integrins: Increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins
44. FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions
45. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell spreading on fibronectin
46. Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
47. The focal adhesion kinase
48. 3
49. The cytoplasmic tyrosines of integrin subunit beta-1 are involved in focal adhesion kinase activation
50. Signaling through focal adhesion kinase
51. Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signaling pathways in fibroblasts
52. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
53. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
54. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
55. Distinct mechanisns mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade
56. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc
57. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ra1
58. Distinct roles of the adaptor protein shc and focal adhesion kinase in integrin signaling to Erk
59. The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases
60. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle
61. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
62. Integrin alpha-2-beta-1 mediates isoform-specific activation of p38 and up-regulation of collagen gene transcription by a mechanism involving the alpha-2 cytoplasmic tail
63. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
64. Signaling to Rho GTPases
65. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
66. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
67. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
68. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins
69. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
70. Cooperation between mDial and ROCK in Rho-induced actin reorganization
71. Integrin-mediated signals regulated by members of the Rho family of GTPases
72. Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression
73. RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism
74. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
75. Activation of Rac and Cdc42 by integrins mediates cell spreading
76. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
77. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin β1
78. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
79. Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
80. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
81. Stimulation of β1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β-receptors
82. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesiondependent cell survival
83. αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF
84. Role of alpha-v-beta-3 integrin in the activation of vascular endothelial growth factor receptor-2
85. The p185(neu)-containing glycoprotein complex of a microfilament-associated signal transduction particle. Purification, reconstitution, and molecular associations with p58(gag) and actin
86. FAK integrates growth-factor and integrin signals to promote cell migration
87. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase
88. Cell anchorage permits efficient signal transduction between Ras and its downstream kinases
89. Growth factor activation of MAP kinase requires cell adhesion
90. An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression
91. Integrins enhance platelet-derived growth factor (PDGF)dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor
92. Integrin-mediated cell adhesion activates mitogenactivated protein kinases
93. Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
94. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
95. Integrin-mediated adhesion regulates Erk nuclear translocation and phosphorylation of ELK-1
96. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
97. Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase
98. Nuclear export of MAP kinase (Erk) involves a MAP kinase kinase (MEK)-dependent active transport mechanism
99. Phosphorylation of the MAP kinase Erk2 promotes its homodimerization and nuclear translocation
100. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells
101. MPI: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
102. Suppression of Raf1 kinase activity and MAP kinase signalling by RKIP
103. Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (Erk) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors
104. Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists
105. Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix
106. Integrin mediated signaling events in human endothelial cells
107. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade
108. Integrins regulate the linkage between upstream and downstream events in G protein-coupled receptor signaling to mitogen-activated protein kinase
109. The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi
110. Role of cholesterol in formation and function of a signaling complex involving alpha-v-beta-3, integrin-associated protein (CD47), and heterotrimeric G proteins
111. Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase
112. Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases
113. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes
114. Localization of G-protein-coupled receptors in health and disease
115. Requirements of focal adhesions and calcium fluxes for interleukin-1-induced Erk kinase activation and c-fos expression in fibroblasts
116. Regulation of interleukin 1 signalling through integrin binding and actin reorganization: Disparate effects on NF-kappa-B and stress kinase pathways
117. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation
118. The recruitment of the interleukin-1 (IL-1) receptor-associated kinase (IRAK) into focal adhesion complexes is required for IL-1beta -induced Erk activation
119. Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2
120. The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23
121. Control of type II transforming growth factor-beta receptor expression by integrin ligation
122. Transforming growth factor-beta overrides the adhesion requirement for surface expression of alpha(5)beta(1) integrin in normal rat kidney fibroblasts. A necessary effect for induction of anchorage-independent growth
123. Interactions between growth factors and integrins: Latent forms of transforming growth factor-beta are ligands for the integrin alpha-v-beta-1
124. The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis
125. Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors
126. Cytokine signaling through stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D
127. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
128. N-cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry
129. Requirement for beta-catenin in anterior-posterior axis formation in mice
130. Cadherins and their connections: Adhesion junctions have broader functions
131. Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways
132. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
133. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
134. Inhibition of beta-catenin-mediated transactivation by cadherin derivatives
135. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation
136. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
137. Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis
138. Direct involvement of N-cadherin-mediated signaling in muscle differentiation
139. p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry
140. E-cadherin-dependent growth suppression is mediated by the cyclindependent kinase inhibitor p27(KIP1)
141. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling
142. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex
143. A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells
144. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
145. Cadherin-mediated regulation of microtubule dynamics
146. Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta-catenin release
147. G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway
148. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
149. Cell-substrate interactions and signaling through ILK
150. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways
151. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
152. The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta-1-integrins
153. Functional interaction between E-cadherin and alpha-v-containing integrins in carcinoma cells
154. Induction of cell scattering by expression of beta-1 integrins in beta-1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function
155. Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases
156. IgCAMs: Bidirectional signals underlying neurite growth
157. Neural cell adhesion molecules of the immunoglobulin superfamily: Role in axon growth and guidance
158. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs
159. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway
160. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
161. NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)
162. Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases
163. NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells
164. A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
165. Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
166. NF-kappa-B activity is induced by neural cell adhesion molecule binding to neurons and astrocytes
167. Distinct neurite outgrowth signaling pathways converge on Erk activation
168. The biology of PECAM-1
169. Ligation of CD31 (PECAM-1) on endothelial cells increases adhesive function of alpha-v-beta-3 integrin and enhances beta-1 integrin-mediated adhesion of eosinophils to endothelial cells
170. Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates
171. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma-1 with PECAM-1/CD31
172. Switched at birth: A new family for PECAM-1
173. Human carcinoembryonic antigen functions as a general inhibitor of anoikis
174. Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation
175. cis-Determinants in the cytoplasmic domain of CEACAM1 responsible for its tumor inhibitory function
176. Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance
177. Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene
178. Mechanisms that regulate the function of the selectins and their ligands
179. Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway
180. Platelet/polymorphonuclear leukocyte interaction: P-selectin triggers protein-tyrosine phosphorylation-dependent CD11b/CD18 adhesion: Role of PSGL-1 as a signaling molecule
181. L-selectin signaling of neutrophil adhesion and degranulation involves p38 mitogen-activated protein kinase
182. Endothelial cell E- and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors
183. E-selectin-dependent signaling via the mitogen-activated protein kinase pathway in vascular endothelial cells
184. Syndecan-regulated receptor signaling
185. Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C
186. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers
187. Tyrosine phosphorylation of syndecan-1 and -4 cytoplasmic domains in adherent B82 fibroblasts
188. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
189. Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3
190. The structural and mechanical complexity of cell-growth control
191. The ErbB signaling network: Receptor heterodimerization in development and cancer
192. Organization and regulation of mitogen-activated protein kinase signaling pathways
193. The JIP group of mitogen-activated protein kinase scaffold proteins
194. Betaarrestin 2: A receptor-regulated MAPK scaffold for the activation of Jnk3
195. Signal transduction: Hanging on a scaffold
196. Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
197. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
198. Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses
199. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
200. PDZ domains in synapse assembly and signalling
201. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
202. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane
203. Compartmentation of G protein-coupled signaling pathways in cardiac myocytes
204. The cytoskeleton and cell signaling: Component localization and mechanical coupling
205. Fibroblast quiescence and the disruption of Erk signaling in mechanically unloaded collagen matrices
206. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
207. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
208. Integrins and actin filaments: Reciprocal regulation of cell adhesion and signaling
209. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures
210. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins
211. Negative regulation of fibroblast motility by Ena/VASP proteins
212. Paxillin interactions
213. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin
214. Interaction between PAK and nck: A template for Nck targets and role of PAK autophosphorylation
215. The Nck SH2/SH3 adaptor protein: A regulator of multiple intracellular signal transduction events
216. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
217. Regulation of the protein kinase Raf1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
218. The protein kinase Pak3 positively regulates Raf1 activity through phosphorylation of serine 338
219. Signaling from Ras to Rac and beyond: Not just a matter of GEFs
220. Cell adhesion regulates the interaction between Nck and p21-activated kinase
221. Temporal and spatial distribution of activated Pak1 in fibroblasts
222. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
223. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
224. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit