Suppression of integrin activation: A novel function of a Ras/Raf- initiated MAP kinase pathway

Cell

Volumn 88, Issue 4, 1997, Pages 521-530

  Hughes, Paul E ^a   Renshaw, Mark W ^a   Pfaff, Martin ^a   Forsyth, Jane ^a   Keivens, Virginia M ^a   Schwartz, Martin A ^a   Ginsberg, Mark H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRUCTURE; ENZYME ACTIVATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0030909050     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81892-9     Document Type: Article

References (46)

1. Alig, L, Edenhofer, A., Hadvary, P., Hurzeler, M., Knopp, D., Muller, M., Steiner, B., Trzeciak, A., and Weller, T. (1992). Low molecular weight, non-peptide fibrinogen receptor antagonists. J. Med. Chem. 35, 4393-4407.
2. 3 and integrin-associated protein. J. Cell Biol. 130, 745-754.
3. Brown, M.T., and Cooper, J.A. (1996). Regulation, substrates and functions of src. Biochem. Biophys. Acta 1287, 121-149.
4. Bruder, J.T., Heidecker, G., and Rapp, U.R. (1992). Serum, TPA, and ras induced expression from AP-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6, 545-555.
5. Burridge, K., Fath, K., Kelly, T., Nuckolls, G., and Turner, C. (1988). Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4, 487-525.
6. Cantley, L.C., Auger, K.R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. (1991). Oncogenes and signal transduction. Cell 64, 281-302.
7. Chen, Y., O'Toole, T., Shipley, T., Forsyth, J., LaFlamme, S., Yamada, K., Shattil, S., and Ginsberg, M. (1994)."Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. J. Biol. Chem. 269, 18307-18310.
8. Chu, Y., Solski, P.A., Khosravi-Far, R., Der, C.J., and Kelly, K. (1996). The mitogen-activated protein kinase phosphatases PAC1, MKP-1 and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J. Biol. Chem. 271, 6497-6501.
9. Clark, E.A., and Hynes, R.O. (1996). Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2, but not cytoskeletal organisation. J. Biol. Chem. 271, 14814-14818.
10. Cox, A.D., Brtva, T.R., Lowe, D.G., and Der, C.J. (1994). R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells. Mol. Cell Biol. 9, 3281-3288.
11. Devary, Y., Gottlieb, R.A., Smeal, T., and Karin, M. (1992). The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71, 1081-1091.
12. Diaz-Gonzalez, F., Forsyth, J., Steiner, B., and Ginsberg, M.H. (1996). Trans-dominant inhibition of integrin function. Mol. Biol. Cell 7, 1939-1951.
13. Dustin, M.L., and Springer, T.A. (1989). T cell receptor crosslinking transiently stimulates adhesiveness through LFA-1. Nature 341, 619-624.
14. Hall, A. (1992). Ras-related GTPases and the cytoskeleton. Mol. Biol. Cell 3, 475-479.
15. Howe, L.R., Leevers, S.J., Gomez, N., Nakielny, S., Cohen, P., and Marshall, C.J. (1992). Activation of the MAP kinase pathway by the protein kinase raf. Cell 71, 335-343.
16. Hughes, P.E., Diaz-Gonzalez, F., Leong, L., Wu, C., McDonald, J.A., Shattil, S.J., and Ginsberg, M.H. (1996). Breaking the integrin hinge: a defined structural constraint regulates integrin signaling. J. Biol. Chem. 271, 6571-6574.
17. Hynes, R.O. (1992). Integrins: versatility, modulation and signaling in cell adhesion. Cell 69, 11-25.
18. Hynes, R., Ali, I., Destree, A., Mautner, V., Perkins, M., Senger, D., Wagner, D., and Smith, K. (1978). A large glycoprotein lost from the surfaces of transformed cells. Ann. NY Acad. Sci. 312, 317-343.
19. Illc, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T., et al. (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.
20. Johansson, M.W., Larsson, E., Luning, B., Pasquale, E.B., and Ruoslahti, E. (1994). Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated β1 integrin. J. Cell Biol. 126, 1299-1309.
21. Kanemitsu, M.Y., and Lau, A.F. (1993). Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogenactivated protein kinase. Mol. Biol. Cell 4, 837-848.
22. Kuijpers, T.W., Mul, E.P., Blom, M., Kovach, N.L, Gaeta, F.C., Tollefson, V., Elices, M.J., and Harlan, J.M. (1993). Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration. J. Exp. Med. 178, 279-284.
23. LaFlamme, S.E., Akiyama, S.K., and Yamada, K.M. (1992). Regulation of fibronectin receptor distribution. J. Cell Biol. 117, 437-447.
24. Law, D.A., Nannizzi-Alaimo, L., and Phillips, D.R. (1996). Outside-in integrin signal transduction. J. Biol. Chem. 271, 10811-10815.
25. Leevers, S.J., Paterson, H.F., and Marshall, C.J. (1994). Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369, 411-414.
26. c-src by a single amino acid change. Proc. Natl. Acad. Sci. USA 83, 4228-4232.
27. Lin, L.-L., Wartmann, M., Lin, A.Y., Knopf, J.L., Seth, A., and Davis, R.J. (1993). cPLA2 is phosphorylated and activated by MAP kinase. Cell 72, 269-278.
28. 1 integrin cytoplasmic domain. J. Biol. Chem. 269, 18311-18314.
29. Marshall, C.J. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
30. Minden, A., Lin, A., Claret, F.X., Abo, A., and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.
31. Minden, A., Lin, A., McMahon M., Lange-Carter, C., Derijard B., Davis R.J., Johnson G.L., and Karin, M. (1994). Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719-1723.
32. O'Toole, T.E., Katagiri, Y., Faull, R.J., Peter, K., Tamura, R., Quaranta, V., Loftus, J.C., Shattil, S.J., and Ginsberg, M.H. (1994). Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124, 1047-1059.
33. O'Toole, T.E., Ylanne, J., and Culley, B.M. (1995). Regulation of integrin affinity states through an NPXY motif in the βsubunit cytoplasmic domain. J. Biol. Chem. 270, 8553-8558.
34. Renshaw, M.W., Lea-Chou, E., and Wang, J.Y.J. (1996). Rac is required for v-Abl tyrosine kinase to activate mitogenesis. Curr. Biol. 6, 76-83.
35. Samuels, M.L, Weber, M.J., Bishop, J.M., and McMahon, M. (1993). Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol. Cell. Biol. 13, 6241-6252.
36. Schlaepfer, D.D., Hanks, S.K., Hunter, T., and van der Geer, P. (1994). Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
37. Schwartz, M.A., Schaller, M.D.,and Ginsberg, M.H. (1995). Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Biol. 11, 549-599.
38. Shattil, S.J., Hoxie, J.A., Cunningham, M., and Brass, L.F. (1985). Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J. Biol. Chem. 260, 11107-11114.
39. Shimizu, Y., VanSeventer, G., Horgan, K., and Shaw, S. (1990). Regulated expression and binding of three VLA (β1) integrin receptors on T cells. Nature 345, 250-253.
40. Sun, H., Charles, C.H., Lau, L.F., and Tonks, N.K. (1993). MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75, 487-493.
41. Urano, T., Emkey, R., and Feig, LA. (1996). Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J. 15, 810-816.
42. Vassbotn, F.S., Havnen, O.K., Heldin, C.H., and Holmsen, H. (1994). Negative feedback regulation of human platelets via autocrine activation of the plateletet derived growth factor alpha receptor. J. Biol. Chem. 269, 13874-13879.
43. White, M.A., Nicolette, C., Minden, A., Polverini, A., Aelst, L.V., Karin, M., and Wigler, M.H. (1995). Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541.
44. Williams, M.J., Hughes, P.E., O'Toole, T.E., and Ginsberg, M.H. (1994). The inner world of cell adhesion: integrin cytoplasmic domains. Trends Cell Biol. 4, 109-112.
45. Wu, C., Kievens, V., O'Toole, T.E., McDonald, J.A., and Ginsberg, M.H. (1995). Integrin activation and cytoskeletal interaction are critical steps in the assembly of a fibronectin matrix. Cell 83, 715-724.
46. Zhang, Z., Vuori, K., Wang, H.G., Reed, J.C., and Ruoslahti, E. (1996). Integrin activation by R-ras. Cell 85, 61-69.