Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

Nature

Volumn 401, Issue 6749, 1999, Pages 173-177

  Yeung, Kam ^a   Seitz, Thomas ^b   Li, Shengfeng ^f   Janosch, Petra ^c   McFerran, Brian ^c   Kaiser, Christian ^b   Fee, Frances ^c   Katsanakis, Kostas D ^c   Rose, David W ^d   Mischak, Harald ^e   Sedivy, John M ^a   Kolch, Walter ^c  

^a BROWN UNIVERSITY   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHOTRANSFERASE; RAF PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN COS1; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT;

3T3 CELLS; ANDROGEN-BINDING PROTEIN; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARRIER PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CLONING, MOLECULAR; COS CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MAP KINASE KINASE KINASE 1; MICE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHOLIPID TRANSFER PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; UTEROGLOBIN;

ANIMALIA;

EID: 0033539167     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/43686     Document Type: Article

References (26)

1. Ferrell, J. E. Jr MAP kinases in mitogenesis and development. Curr. Top. Dev. Biol. 33, 1-60 (1996).
2. Morrison, D. K. & Cutler, R. E. The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9, 174-179 (1997).
3. Moodie, S. A., Willumsen, B. M., Weber, M. J. & Wolfman, A. Complexes of Ras/GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260, 1658-1661 (1993).
4. Schaeffer, H. J. et al. MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281, 1668-1671 (1998).
5. Bruder, J. T., Heidecker, G. & Rapp, U. R. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6, 545-556 (1992).
6. Li, S. et al. Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins. EMBO J. 14, 685-696 (1995).
7. Schoentgen, F. & Jolles, P. From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site. FEBS Lett. 369, 22-26 (1995).
8. Kortenjann, M. Thomae, O. & Shaw, P. E. Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol. Cell. Biol. 14, 4815-4824 (1994).
9. Rapp, U. R., Troppmair, J., Beck, T. & Birrer, M. J. Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant. Oncogene 9, 3493-3498 (1994).
10. Kolch, W. et al. Raf revertant cells resist transformation by non-nuclear oncogenes and are deficient in the induction of early response genes by TPA and serum. Oncogene 8, 361-370 (1993).
11. Catling, A. D., Schaeffer, H. J., Reuter, C. W., Reddy, G. R. & Weber, M. J. A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Mol. Cell. Biol. 15, 5214-5225 (1995).
12. Kolch, W. et al. Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding. Oncogene 13, 1305-1314 (1996).
13. Hallberg, B., Rayter, S. I. & Downward, J. Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. J. Biol. Chem. 269, 3913-3916 (1994).
14. Ferrell, J. E. Jr Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 21, 460-466 (1996).
15. Tombes, R. M. et al. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem. J. 330, 1451-1460 (1998).
16. Marshall, C. J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell, 80, 179-185 (1995).
17. Sewing, A., Wiseman, B., Lloyd, A. C & Land, H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol. Cell. Biol. 17, 5588-5597 (1997).
18. Woods, D. et al. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol. Cell. Biol. 17, 5598-5611 (1997).
19. Grandy, D. K. et al. Purificaton, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography. Mol. Endocrinol. 4, 1370-1376 (1990).
20. Gjorup, O. V., Rose, P. E., Holman, P. S., Bockus, B. J. & Schaffhausen, B. S. Protein domains connect cell cycle stimulation directly to initiation of DNA replication. Proc. Natl Acad. Sci. USA 91, 12125-12129 (1994).
21. Häfner, S. et al. Mechanism of inhibition of Raf-1 by protein kinase A. Mol. Cell. Biol. 14, 6696-6703 (1994).
22. Guan, K. L. & Dixon, J. E. Eucaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192, 262-267 (1991).
23. Mischak, H. et al. Negative regulation of Raf-1 by phosphorylation of serine 621. Mol. Cell. Biol. 16, 5409-5418 (1996).
24. Lavbinsky, R. M. et al. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. USA 95, 2920-2925 (1998).
25. Rose, D. W., McCabe, G., Feramisco, J. R. & Adler, M. Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis, J. Cell Biol. 119, 1405-1411 (1992).
26. Minden, A. et al. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719-1723 (1994).