Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

Current Biology

Volumn 10, Issue 12, 2000, Pages 719-722

  Arthur, William T ^a   Petch, Leslie A ^a   Burridge, Keith ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034659526     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00537-6     Document Type: Article

References (25)

1. Van Aelst L., D'Souza-Schorey C. Rho GTPases and signaling networks. Genes Dev. 11:1997;2295-2322.
2. Schoenwaelder S.M., Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol. 11:1999;274-286.
3. Barry S.T., Flinn H.M., Humphries M.J., Critchley D.R., Ridley A.J. Requirement for Rho in integrin signalling. Cell Adhes Commun. 4:1997;387-398.
4. Gimond C., van Der Flier A., van Delft S., Brakebusch C., Kuikman I., Collard J.G.et al. Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol. 147:1999;1325-1340.
5. Hotchin N.A., Kidd A.G., Altroff H., Mardon H.J. Differential activation of focal adhesion kinase, Rho and Rac by the ninth and tenth FIII domains of fibronectin. J Cell Sci. 112:1999;2937-2946.
6. Takaishi K., Sasaki T., Kato M., Yamochi W., Kuroda S., Nakamura T.et al. Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility. Oncogene. 9:1994;273-279.
7. Ridley A.J., Comoglio P.M., Hall A. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol. 15:1995;1110-1122.
8. Nobes C.D., Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol. 144:1999;1235-1244.
9. Ren X.D., Kiosses W.B., Schwartz M.A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18:1999;578-585.
10. Thomas S.M., Brugge J.S. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol. 13:1997;513-609.
11. Kaplan K.B., Swedlow J.R., Morgan D.O., Varmus H.E. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 9:1995;1505-1517.
12. Hall C.L., Lange L.A., Prober D.A., Zhang S., Turley E.A. pp60(c-src) is required for cell locomotion regulated by the hyaluronan receptor RHAMM. Oncogene. 13:1996;2213-2224.
13. Klinghoffer R.A., Sachsenmaier C., Cooper J.A., Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18:1999;2459-2471.
14. Fincham V.J., Frame M.C. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17:1998;81-92.
15. Fincham V.J., Chudleigh A., Frame M.C. Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J Cell Sci. 112:1999;947-956.
16. Felsenfeld D.P., Schwartzberg P.L., Venegas A., Tse R., Sheetz M.P. Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol. 1:1999;200-206.
17. Hanke J.H., Gardner J.P., Dow R.L., Changelian P.S., Brissette W.H., Weringer E.J.et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem. 271:1996;695-701.
18. Sander E.E., ten Klooster J.P., van Delft S., van der Kammen R.A., Collard J.G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol. 147:1999;1009-1022.
19. Bagrodia S., Taylor S.J., Creasy C.L., Chernoff J., Cerione R.A. Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem. 270:1995;22731-99999. Erratum: J Biol Chem 271:1250.
20. Ridley A.J., Self A.J., Kasmi F., Paterson H.F., Hall A., Marshall C.J., Ellis C. rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J. 12:1993;5151-5160.
21. Chang J.H., Gill S., Settleman J., Parsons S.J. c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J Cell Biol. 130:1995;355-368.
22. Dumenil G., Sansonetti P., Tran Van Nhieu G. Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation. J Cell Sci. 113:2000;71-80.
23. Nakahara H., Mueller S.C., Nomizu M., Yamada Y., Yeh Y., Chen W. Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. J Biol Chem. 273:1997;9-12.
24. Tatsis N., Lannigan D.A., Macara I.G. The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain. J Biol Chem. 273:1998;34631-34638.
25. Rottner K., Hall A., Small J.V. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol. 9:1999;640-648.