frazzled Encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance

Cell

Volumn 87, Issue 2, 1996, Pages 197-204

  Kolodziej, Peter A ^a,b   Timpe, Leslie C ^a,d   Mitchell, Kevin J ^c   Fried, Sharon R ^a   Goodman, Corey S ^c   Jan, Lily Yeh ^a   Jan, Yuh Nung ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELETED IN COLORECTAL CANCER PROTEIN; FIBRONECTIN; FRAZZLED PROTEIN; IMMUNOGLOBULIN; MEMBRANE PROTEIN; NETRIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DROSOPHILA; EMBRYO; FEMALE; IN SITU HYBRIDIZATION; MALE; MOTOR NERVE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA; VERTEBRATA;

EID: 0030592577     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81338-0     Document Type: Article

References (29)

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
2. Bier, E., Vaessin, H., Shepherd, S., Lee, K., McCall, K., Barbel, S., Ackerman, L., Caretto, R., Uemura, T., Grell, E., Jan, L.Y., and Jan, Y.N. (1989). Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 3, 1273-1287.
3. Brand, A.H., and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
4. Chan, S.S.-Y., Zheng, H., Su, M.W., Wilk, R., Killeen, M.T., Hedgecock, E.M., and Culotti, J.G. (1996). UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell, this issue.
5. Chuong, C.M., Jiang, T.X., Yin, E., and Widelitz, R.B. (1994). cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interaction. Dev. Biol. 164, 383-397.
6. Colamarino, S.A., and Tessier-Lavigne, M. (1995). The axonal chemoattractant Netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629.
7. Fearon, E.R., Cho, K.R., Nigro, J.M., Kern, S.E., Simons, J.W., Ruppert, J.M., Hamilton, S.R., Preisinger, A.C.,Thomas, G., Kinzler, K.W., and Vogelstein, B. (1990). Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247, 49-56.
8. Goodman, C.S. (1996). Mechanisms and molecules that control growth cone guidance. Annu. Rev. Neurosci. 19, 341-377.
9. Hamelin, M., Zhou, Y., Su, M.W., Scott, I.M., and Culotti, J.G. (1993). Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327-330.
10. Harris, R., Sabatelli, L.M., and Seeger, M.A. (1996). Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs. Neuron 17, 217-218.
11. Hedgecock, E.M., Culotti, J.G., and Hall, D.H. (1990). The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61-85.
12. Hedrick, L, Cho, K.R., Fearon, E.R., Wu, T.C., Kinzler, K.W., and Vogelstein, B. (1994). The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev. 8, 1174-1183.
13. Higgins, D.G. (1994). CLUSTAL V: multiple alignment of DNA and protein sequences. Methods Mol. Biol. 25, 307-318.
14. Ishii, N., Wadsworth, W.G., Stern, B.D., Culotti, J.G., and Hedgecock, E.M. (1992). UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881.
15. Keino-Masu, K., Masu, M, Hinck, L., Leonardo, D.E., Chan, S., Culotti, J., and Tessier-Lavigne, M. (1996). Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell, this issue.
16. Kennedy, T.E., Serafini, T., de la Torre, J.R., and Tessier-Lavigne, M. (1994). Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435.
17. Kolodziej, P.A., Jan, L.Y., and Jan, Y.N. (1995). Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo. Neuron 15, 273-286.
18. Luo, L., Liao, Y.J., Jan, L.Y., and Jan, Y.N. (1994). Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8, 1787-1802.
19. Mitchell, K.J., Doyle, J.L., Serafini, T., Kennedy, T.E., Tessier-Lavigne, M., Goodman, C.S., and Dickson, B.J. (1996). Genetic analysis of Netrin genes in Drosophila: netrins guide CNS commissural axons and peripheral motor axons. Neuron 17, 203-215.
20. Patthy, L. (1990). Homology of a domain of the growth hormone/ prolactin receptor family with type III modules of fibronectin [letter]. Cell 61, 13-14.
21. Pierceall, W.E., Cho, K.R., Getzenberg, R.H., Reale, M.A., Hedrick, L., Vogelstein, B., and Fearon, E.R. (1994). NIH3T3 cells expressing the Deleted in Colorectal Cancer (DCC) tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells. J. Cell. Biol. 124, 1017-1027.
22. Pirotta, V. (1986). Cloning Drosophila genes. In Drosophila: A Practical Approach, D.R. Roberts, ed. (Oxford: IRL Press), pp. 83-100.
23. Seeger, M., Tear, G., Ferres-Marco, D., and Goodman, C.S. (1993). Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10, 409-426.
24. Serafini, T., Kennedy, T.E., Galko, M.J., Mirzayan, C., Jessell, T.M., and Tessier-Lavigne, M. (1994). The Netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424.
25. Tessier-Lavigne, M. (1994). Axon guidance by diffusible repellants and attractants. Curr. Opin. Genet. Dev. 4, 596-601.
26. Van Vactor, D.V., Sink, H., Fambrough, D., Tsoo, R., and Goodman, C.S. (1993). Genes that control neuromuscular specificity in Drosophila. Cell 73, 1137-1153.
27. Vielmetter, J., Kayyem, J.F., Roman, J.M., and Dreyer, W.J. (1994). Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J. Cell Biol. 127, 2009-2020.
28. Wadsworth, W., Bhatt, H., and Hedgecock, E. (1996). Neuroglia and pioneer neurons express UNC-6 to provide global and local Netrin cues for guiding migrations in C. elegans. Neuron 16, 35-46.
29. Williams, A.F., and Barclay, A.N. (1988). The immunoglobulin superfamily - domains for cell surface recognition. Annu. Rev. Immunol. 6, 381-405.