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Volumn 11, Issue 2, 1999, Pages 197-202

Interactions between mitogenic stimuli, or, a thousand and one connections

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; RECEPTOR; TYROSINE KINASE RECEPTOR;

EID: 0032910337     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(99)80026-X     Document Type: Article
Times cited : (221)

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    • Differential effects of protein kinase A on Ras effector proteins
    • This paper describes complex crosstalk between Ras-induced pathways and the cAMP/PKA pathway, and their effects on the regulation of thyroid cell growth.
    • Miller M.J., Rioux L., Prendergast G.V., Cannon S., White M.A., Meinkoth J.L. Differential effects of protein kinase A on Ras effector proteins. Mol Cell Biol. 18:1998;3718-3726. This paper describes complex crosstalk between Ras-induced pathways and the cAMP/PKA pathway, and their effects on the regulation of thyroid cell growth.
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    • The mitogen activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscsle cells
    • This paper unravels paradoxical effects of MAPK on smooth muscle cells. MAPK is usually mitogenic, but in the presence of phospholipase A2 and high levels of cyclooxygenase-2 it leads to generation of prostaglandin E2 (PGE2) and cAMP, which inhibit cell growth.
    • Bornfeldt K.E., Campbell J.S., Koyama H., Argast G.M., Leslie C.C., Raines E.W., Krebs E.G., Ross R. The mitogen activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscsle cells. J Clin Invest. 100:1997;875-885. This paper unravels paradoxical effects of MAPK on smooth muscle cells. MAPK is usually mitogenic, but in the presence of phospholipase A2 and high levels of cyclooxygenase-2 it leads to generation of prostaglandin E2 (PGE2) and cAMP, which inhibit cell growth.
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