Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation

Journal of Cell Biology

Volumn 137, Issue 4, 1997, Pages 939-952

  Screaton, Robert A ^a   Penn, Linda Z ^b   Stanners, Clifford P ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; CARCINOEMBRYONIC ANTIGEN; PROTEIN BCL 2; TUMOR MARKER;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE G0 PHASE; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; MOUSE; MYOBLAST; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOEMBRYONIC ANTIGEN; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; G0 PHASE; GENES, BCL-2; GENES, MYC; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEIN P55(V-MYC); ONCOGENES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; TRANSFECTION;

EID: 0030913147     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.137.4.939     Document Type: Article

References (64)

1. Adams, J.M., A.W. Harris, C.A. Pinkert, L.M. Corcoran, W.S. Alexander, S. Cory, R.D. Palmitter, and R.L. Brinster. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (Lond.). 318:533-538.
2. Ahnen, D.J., K. Kinoshita, P.K. Nakane, and W.R. Brown. 1987. Differential expression of carcinoembryonic antigen and secretory component during colonic epithelial cell differentiation and in colonic carcinomas. Gastroenterology. 93:1330-1339.
3. Alema, S., and F. Tato. 1994. Oncogenes and muscle differentiation: multiple mechanisms of interference. Semin. Cancer Biol. 5:147-156.
4. Averbach, A.M., and P.H. Sugarbaker. 1995. Use of Tumor Markers and Radiologic Tests in Follow-up. In Cancer of the Colon, Rectum and Anus. A.M. Cohen and S.J. Winawer, editors. McGraw-Hill, New York. 725-751.
5. Beauchemin, N., S. Benchimol, D. Cournoyer, A. Fuks, and C.P. Stanners. 1987. Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. Mol. Cell. Biol. 7:3221-3230.
6. Bedi, A., P. Pasricha, A.J. Akhtar, J.P. Barber, G.C. Bedi, F.M. Giardiello, B.A. Zehnbauer, S.R. Hamilton, and R.J. Jones. 1995. Inhibition of apoptosis during development of colorectal cancer. Cancer Res. 55:1811-1816.
7. Benchimol, S., A. Fuks, S. Jothy, N. Beauchemin, K. Shirota, and C.P. Stanners. 1989. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. 57:327-334.
8. Bissonnette, R.P., F. Echeverri, A. Mahboubi, and D.R. Green. 1992. Apoptotic cell death induced by c-myc is inhibited by Bcl2. Nature (Lond.). 359:552-554.
9. Bosari, S., L. Moneghini, D. Graziani, A.K.C. Lee, J.J. Murray, G. Coggi, and G. Viale. 1995. bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum. Pathol. 26:534-540.
10. Boucher, D., D. Cournoyer, C.P. Stanners, and A. Fuks. 1989. Studies on the control of gene expression of the carcinoembryonic antigen family in human tissue. Cancer Res. 49:847-852.
11. Braun, T., E. Bober, and H.H. Arnold. 1992. Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5. Genes Dev. 5:888-902.
12. Cournoyer, D., N. Beauchemin, D. Boucher, S. Benchimol, A. Fuks, and C.P. Stanners. 1988. Transcription of the genes of the carcinoembryonic antigen family in malignant and nonmalignant tissues. Cancer Res. 48:3153-3157.
13. Crescenzi, M., D.H. Crouch, and F. Tato. 1994. Transformation by myc prevents fusion but not biochemical differentiation of C2C12 myoblasts: mechanisms of phenotypic correction in mixed culture with normal cells. J. Cell Biol. 125:1137-1145.
14. De Giovanni, C., P.L. Lollini, R. Dolcetti, L. Landuzzi, G. Nicoletti, E. D'Andrea, K. Scotland, and P. Nanni. 1993. Uncoupling of growth inhibition and differentiation in dexamethasone-treated human rhabdomyosarcoma cells. Br. J. Cancer. 67:674-679.
15. Denis, N., S. Blanc, M.P. Leibotvitch, N. Nicolaiew, F. Dautry, M. Raymond-jean, J. Kruh, and A. Kitzis. 1987. c-myc oncogene expression inhibits the initiation of myogenic differentiation. Exp. Cell Res. 172:212-217.
16. Eidelman, F., A. Fuks, L. DeMarte, M. Taheri, and C.P. Stanners. 1993. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. J. Cell Biol. 123:467-475.
17. Evan, G.I., and T.D. Littlewood. 1993. The role of c-myc in cell growth. Curr. Opin. Genet. Dev. 3:44-49.
18. Evan, G.I., A.H. Wyllie, C.S. Gilbert, T.D. Littlewood, H. Land, M. Brooks, C.M. Waters, L.Z. Penn, and D.C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell. 69:119-128.
19. Evan, G., E. Harrington, A. Fanidi, H. Land, B. Amati, and M. Bennett. 1994. Integrated control of cell proliferation and cell death by the c-myc oncogene. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 345:269-275.
20. Facchini, L.M., S. Chen, and L.J.Z. Penn. 1994. Dysfunction of the Myc-induced apoptosis mechanism accompanies c-myc activation in the tumorigenic L929 cell line. Cell Growth Differ. 5:637-646.
21. Falcone, G., F. Tato, and S. Alema. 1985. Distinctive effects of the viral oncogenes myc, erb, fps, and src on the differentiation program of quail myogenic cells. Proc. Natl. Acad. Sci. USA. 82:426-430.
22. Fanidi, A., E. Harrington, and G.I. Evan. 1992. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (Lond.). 359:554-556.
23. Gold, P., and S.O. Freedman. 1965. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121:439-462.
24. Guillem, J.G., P.B. Paty, and N. Rosen. 1995. Molecular Biology of Colorectal Cancer. In Cancer of the Colon, Rectum and Anus. A.M. Cohen and S.J. Winawer, editors. McGraw-Hill, New York. 149-156.
25. Hefta, S.A., L.J.F. Hefta, T.D. Lee, R.J. Paxton, and J.E. Shively. 1988. Carcinoembryonic antigen is anchored to the membrane by covalent attachment to a glycophosphatidylinositol moiety: identification of the ethanolamine linkage site. Proc. Natl. Acad. Sci. USA. 85:4648-4652.
26. Hermeking, H., and D. Eick. 1994. Mediation of c-Myc apoptosis by p53. Science (Wash. DC). 265:2091-2093.
27. Hinoda, Y., H. Takahashi, T. Higashide, T. Nakano, Y. Arimura, M. Yoshimoto, M. Tsujisaki, K. Imai, and A. Yachi. 1991. Correlated expression of mRNAs of carcinoembryonic antigen and non-specific cross-reacting antigen genes in malignant and nonmalignant tissues of the colon. Jpn. J. Clin. Oncol. 21:75-81.
28. Hunter, T. 1991. Cooperation between oncogenes. Cell. 64:249-270.
29. Hunter, T. 1993. Oncogenes and cell proliferation. Curr. Opin. Genet. Dev. 3:1-4.
30. Ilantzis, C., S. Jothy, L.C. Alpert, P. Draber, and C.P. Stanners. 1997. Cell-surface levels of human carcinoembryonic antigen are inversely correlated with colonocyte differentiation in colon carcinogenesis. Lab. Invest. In press.
31. Jothy, S., S-Y. Yuan, and K. Shirota. 1993. Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. Am. J. Pathol. 143:250-257.
32. Kelly, K., B.H. Cochran, C.D. Stiles, and P. Leder. 1983. Cell specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell. 35:603-610.
33. Knudsen, K.A. 1990. Cell adhesion molecules in myogenesis. Curr. Opin. Cell Biol. 2:902-906.
34. Korsmeyer, S. 1992. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood. 85:879-886.
35. Korsmeyer, S. 1995. Regulators of cell death. Trends Genet. 11:101-105.
36. La Rocca, S.A., M. Grossi, G. Falcone, S. Alema, and F. Tato. 1989. Interaction with normal cells suppresses the transformed phenotype of v-myc-transformed quail muscle cells. Cell. 58:123-131.
37. La Rocca, S.A., D.H. Crouch, and D.A.F. Gillespie. 1994. c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation. Oncogene. 9:3499-3508.
38. Land, H., L.F. Parada, and R.A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (Lond.). 304:596-602.
39. McDonnell, T.J., and S.J. Korsmeyer. 1991. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature (Lond.). 349:254-256.
40. McDonnell, T.J., N. Deane, F.M. Platt, G. Nunez, U. Jaeger, J.P. McKearn, and S.J. Korsmeyer. 1989. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:79-88.
41. Miyazaki, T., Z.-J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E.L. Barsoumian, R.M. Perlmutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell. 81:223-231.
42. Morgenstern, J.P., and H. Land. 1990. Advanced mammalian gene transferhigh titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 12:3587-3596.
43. Murray, A., and T. Hunt. 1993. The Cell Cycle. Oxford University Press, Oxford, UK.
44. Nadal-Ginard, B. 1978. Commitment, fusion, and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis. Cell. 15:855-864.
45. Neumaier, M., S. Paululat, A. Chan, P. Matthaes, and C. Wagener. 1993. Biliary glycoprotein, a potential cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc. Natl. Acad. Sci. USA. 90:10744-10748.
46. Oikawa, S., C. Inusuka, M. Kuroki, Y. Matsuoka, G. Kosaki, and H. Nakazato. 1989. Cell adhesion of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem. Biophys. Res Commun. 164:39-45.
47. Olson, E., and W.H. Klein. 1994. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev. 8:1-8.
48. Olson, E.N., G. Spizz, and M.A. Tainsky. 1987. The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation. Mol. Cell. Biol. 7:2104-2111.
49. Packham, G., and J.L. Cleveland. 1995. c-Myc and apoptosis. Biochim. Biophys. Acta. 1242:11-28.
50. Penn, L.J.Z., E.M. Laufer, and H. Land. 1990. C-Myc: Evidence for Multiple Regulatory Functions. In Seminars in Cancer Biology. N. Jones, editor. W.B. Saunders Co., London. 69-80.
51. Reed, J.C., H.S. Talwar, M. Cuddy, G. Baffy, J. Williamson, U.R. Rapp, and G.J. Fisher. 1991. Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. Exp. Cell Res. 195:277-283.
52. Rojas, M., L. DeMarte, R.A. Screaton, and C.P. Stanners. 1996. Radical differences in functions of closely related members of the human carcinoembryonic antigen gene family. Cell Growth Differ. 7:655-662.
53. Sinicrope, F.A., S.B. Ruan, K.R. Cleary, L.C. Stephens, J.J. Lee, and B. Levin. 1995. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 55:237-241.
54. Spencer, C.A., and M. Groudine. 1991. Control of c-myc regulation in normal and neoplastic cells. Adv. Cancer Res. 56:1-48.
55. Stanners, C.P., and J.E. Till. 1960. DNA synthesis in individual L-strain mouse cells. Biochim. Biophys. Acta. 37:406-419.
56. Strasser, A., A.W. Harris, M.L. Bath, and S. Cory. 1990. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature (Lond.). 348:331-333.
57. Takami, N., Y. Misumi, M. Kuroki, Y. Matsuoka, and Y. Ikehara. 1988. Evidence for carboxyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen. J. Biol. Chem. 263:12716-12720.
58. Wagner, A.J., M.B. Small, and N. Hay. 1993. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol. Cell. Biol. 13:2432-2440.
59. Wagner, A.J., J.M. Kokontis, and N. Hay. 1994. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 Waf1/Cip1. Genes Dev. 8:2817-2830.
60. Weinberg, R.A. 1989. Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res. 49:3713-3721.
61. Yaffe, D. 1968. Retention of differentiation potentialities during prolonged cultivation of myogenic cells. Proc. Natl. Acad. Sci. USA. 61:477-483.
62. Yaffe, D., and O. Saxel. 1977. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature (Lond.). 270:725-727.
63. Zhou, H., A. Fuks, G. Alcaraz, T.J. Bolling, and C.P. Stanners. 1993. Homophilic adhesion between Ig superfamily carcinoembryonic antigen molecules involves double reciprocal bonds. J. Cell Biol. 122:951-960.
64. Zhu, W., A. Cowie, G.W. Wasfy, L.Z. Penn, B. Leber, and D.W. Andrews. 1996. Bcl-2 mutants with restricted sub-cellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO (Eur. Mol. Biol. Organ.) J. 15:4130-4141.