Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway

Journal of Cell Science

Volumn 112, Issue 5, 1999, Pages 695-706

  Aplin, Andrew E ^a   Juliano, R L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Actin; Cdc42; Integrin; MAPK; RhoA

Indexed keywords

ACTIN; EPIDERMAL GROWTH FACTOR; FIBRONECTIN; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOSKELETON; EXTRACELLULAR MATRIX; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3 CELLS; ACTINS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CDC42 GTP-BINDING PROTEIN; CELL ADHESION; CELL CYCLE PROTEINS; CELL DIVISION; CYTOCHALASIN D; CYTOSKELETON; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GROWTH SUBSTANCES; GTP-BINDING PROTEINS; INTEGRINS; LUCIFERASES; MICE; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; THIAZOLES; THIAZOLIDINES; TRANSFECTION;

ANIMALIA;

EID: 0033000286     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Aktories, K., Mohr, C. and Koch, G. (1992). Clostridium botulinum C3 ADP-ribosyltransferase. Curr. Topics Microbiol. Immunol. 175, 115-131.
2. Aplin, A. E., Howe, A., Alahari, S. K. and Juliano, R. L. (1998). Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, Ig-CAMs and selectins. Pharm. Rev. 50, 197-262.
3. Assoian, R. K. (1997). Anchorage-dependent cell cycle progression. J. Cell Biol. 136, 1-4.
4. Barry, S. T. and Critchley, D. R. (1994). The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions. J. Cell Sci. 107, 2033-2045.
5. Bohmer, R. M., Scharf, E. and Assoian, R. K. (1996). Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Mol. Biol. Cell. 7, 101-111.
6. Brunet, A. and Pouyssegur, J. (1998). Mammalian MAP kinase modules: how to transduce specific signals. Essays Biochem. 32, 1-16.
7. Burridge, K., Turner, C. E. and Romer, L. H. (1992). Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol. 119, 893-903.
8. Cary, L. A., Chang, J. F. and Guan, J. L. (1996). Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109, 1787-1794.
9. Cazaubon, S., Chaverot, N., Romero, I. A., Girault, J. A., Adamson, P., Strosberg, A. D. and Couraud, P. O. (1997). Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways. J. Neurosci. 17, 6203-6212.
10. Chen, Q., Kinch, M. S., Lin, T. H., Burridge, K. and Juliano, R. L. (1994). Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269, 26602-26605.
11. Chen, Q., Lin, T. H., Der, C. J. and Juliano, R. L. (1996). Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras. J. Biol. Chem. 271, 18122-18127.
12. Chrzanowska-Wodnicka, M. and Burridge, K. (1996). Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403-1415.
13. Clark, E. A., King, W. G., Brugge, J. S., Symons, M. and Hynes, R. O. (1998). Integrin-mediated signals regulated by members of the Rho family of GTPases. J Cell Biol. 142, 573-586.
14. Cobb, M. H., Xu, S., Hepler, J. E., Hutchison, M., Frost, J. and Robbins, D. J. (1994). Regulation of the MAP kinase cascade. Cell. Mol. Biol. Res. 40, 253-256.
15. Coso, O. A., Chiariello, M., Yu, J. C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J. S. (1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
16. Coue, M., Brenner, S. L., Spector, I. and Korn, E. D. (1987). Inhibition of actin polymerization by latrunculin A. FEBS Lett. 213, 316-318.
17. Daniels, D., Hall, P. S. and Bokoch, G. M. (1998). Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J. 17, 754-764.
18. Davis, R. J. (1995). Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42, 459-467.
19. Fang, F., Orend, G., Watanabe, N., Hunter, T. and Ruoslahti, E. (1996). Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 271, 499-502.
20. Hill, C. S., Wynne, J. and Treisman, R. (1995). The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81, 1159-1170.
21. Hotchin, N. A. and Hall, A. (1995). The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular Rho/Rac GTPases. J. Cell Biol. 131, 1857-1865.
22. Howe, A., Aplin, A. E., Alahari, S. K. and Juliano, R. L. (1998). Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10, 220-231.
23. Hynes, R. O. (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
24. Inoue, H., Yamashita, A. and Hakura, A. (1996). Adhesion-dependency of serum-induced p42/p44 MAP kinase activation is released by retroviral oncogenes. Virology 225, 223-226.
25. Kozma, R., Ahmed, S., Best, A. and Lim, L. (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and tilopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15, 1942-1952.
26. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.
27. Lamaze, C., Chuang, T. H., Terlecky, L. J., Bokoch, G. M. and Schmid, S. L. (1996). Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382, 177-179.
28. Lavoie, J. N., G, L. A., Brunet, A., Muller, R. and Pouyssegur, J. (1996). Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271, 20608-20616.
29. Lim, L., Manser, E., Leung, T. and Hall, C. (1996). Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem. 242, 171-185.
30. Lin, T. H., Aplin, A. E., Shen, Y., Chen, Q., Schaller, M., Romer, L., Aukhil, I. and Juliano, R. L. (1997a). Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J. Cell Biol. 136, 1385-1395.
31. Lin, T. H., Chen, Q., Howe, A. and Juliano, R. L. (1997b). Cell anchorage permits efficient signal transduction between Ras and its downstream kinases. J. Biol. Chem. 272, 8849-8852.
32. Marshall, C. J. (1995). Opportunities for pharmacological intervention in the Ras pathway. Ann. Oncol. 6, 63-67.
33. Miki, H., Sasaki, T., Takai, Y. and Takenawa, T. (1998). Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature 391, 93-96.
34. Minden, A., Lin, A., Claret, F. X., Abo, A. and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.
35. Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K. and Yamada, K. M. (1995). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol. 131, 791-805.
36. Miyamoto, S., Teramoto, H., Gutkind, J. S. and Yamada, K. M. (1996). Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
37. Nobes, C. D. and Hall, A. (1995). Rho. Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
38. 1. Science 269, 1270-1272.
39. Price, L. S., Leng, J., Schwartz, M. A. and Bokoch, G. M. (1998). Activation of Rac and Cdc42 by integrins mediates cell spreading Mol. Biol. Cell 9, 1863-1871.
40. Renshaw, M. W., Ren, X. D. and Schwartz, M. A. (1997). Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16, 5592-5599.
41. Resnitzky, D. (1997). Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression. Mol. Cell. Biol. 17, 5640-5647.
42. Richardson, A. and Parsons, T. (1996). A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature 380, 538-540.
43. Ridley, A. J. (1996). Rho: theme and variations. Curr. Biol. 6, 1256-1264.
44. Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
45. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
46. Romer, L. H., McLean, N., Turner, C. E. and Burridge, K. (1994). Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol. Biol. Cell. 5, 349-361.
47. Ruoslahti, E. (1991). Integrins. J. Clin. Invest. 87, 1-5.
48. Schwartz, M. A. (1997). Integrins, oncogenes, and anchorage independence. J. Cell Biol. 139, 575-578.
49. Schwarte, M. A., Toksoz, D. and Khosravi-Far, R. (1996). Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway. EMBO J. 15, 6525-6530.
50. Sekine, A., Fujiwara, M. and Narumiya, S. (1989). Asparagine residue in the Rho gene product is the modification site for botulinum ADP-ribosyltransferase. J. Biol. Chem. 264, 8602-8605.
51. Seufferlein, T., Withers, D. J., Mann, D. and Rozengurt, E. (1996). Dissociation of mitogen-activated protein kinase activation from p125 focal adhesion kinase tyrosine phosphorylation in Swiss 3T3 cells stimulated by bombesin, lysophosphatidic acid, and platelet-derived growth factor. Mol. Biol. Cell. 7, 1865-1875.
52. Spector, I., Shochet, N. R., Kashman, Y. and Groweiss, A. (1983). Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science 219, 493-495.
53. Symons, M., Derry, J. M., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F., Francke, U. and Abo, A. (1996). Wiskott-Aldrich syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization. Cell 84, 723-734.
54. Treisman, R. (1996). Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8, 205-215.
55. Wary, K. K., Mainiero, F., Isakoff, S. J., Marcantonio, E. E. and Giancotti, F. G. (1996). The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87, 733-743.
56. Zhu, X., Ohtsubo, M., Bohmer, R. M., Roberts, J. M. and Assoian, R. K. (1996). Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133, 391-403.