New insights into integrin-ligand interaction

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2302-2306

  Loftus, Joseph C ^a   Liddington, Robert C ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LIGAND; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; METAL ION; PROTEIN SUBUNIT; CELL ADHESION MOLECULE;

ALLOSTERISM; BINDING AFFINITY; CELL ADHESION; CRYSTAL STRUCTURE; EXTRACELLULAR MATRIX; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; BLOOD VESSEL; CHEMISTRY; MACROMOLECULE; PHYSIOLOGY;

ALLOSTERIC REGULATION; ANIMALS; BLOOD VESSELS; CELL ADHESION; CELL ADHESION MOLECULES; EXTRACELLULAR MATRIX; HUMANS; INTEGRINS; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; MODELS, STRUCTURAL; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 0031569914     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/jci119408     Document Type: Review

References (34)

1. Leahy, D., W. Hendrickson, I. Aukhil, and H. Erickson. 1992. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science (Wash. DC). 258:987-991.
2. Main, A., T. Harvey, M. Baron. J. Boyd, and I. Campbell. 1992. The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Cell. 71:671-678.
3. Jones, E.Y., K. Harlos, M.J. Bottomly, R.C. Robinson, P.C. Driscoll, R.M. Edwards, J.M. Clements, T.J. Dudgeon, and D.I. Stuart. 1995. Crystal structure of an integrin binding fragment of the vascular cell adhesion molecule-1 at 1.8 Å resolution. Nature (Lond.). 373:539-544.
4. 2) integrin. Proc. Natl. Acad. Sci. USA. 92:10277-10281.
5. Lee, J., P. Rieu, M. Arnaout, and R. Liddington. 1995. Crystal structure of the A domain from the a subunit of integrin CR3 (CD11b/CD18). Cell. 80: 631-638.
6. 2 integrin CR3 (Cd11b/CD18) is essential for ligand binding. Cell. 72:857-867.
7. 2 integrins for interactions with the intercellular adhesion molecule 1 (ICAM-1) and C3bi. J. Biol. Chem. 270: 12531-12535.
8. Corbi, A.L., L.J. Miller, K. O'Connor, R.S. Larson, and T.A. Springer. 1987. cDNA cloning and complete primary structure of the a subunit of a leukocyte adhesion protein. EMBO (Eur. Mol. Biol. Organ.) J. 6:4023-4028.
9. 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science (Wash. DC). 249:915-918.
10. Huang, C., and T.A. Springer. 1995. A binding interface on the I-domain of lymphocyte function associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule-1 (ICAM-1). J. Biol. Chem. 270: 19008-19016.
11. Rieu, P., T. Sugimori, D.L. Griffith, and M.A. Arnaout. 1996. Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor. J. Biol. Chem. 271: 15858-15861.
12. Loftus, J.C., J.W. Smith, and M.H. Ginsberg. 1994. Integrin-mediated cell adhesion: the extracellular face. J. Biol. Chem. 269:25235-25238.
13. 1 subunit using activating and inhibitory antibodies. J. Biol. Chem. 268:17597-17601.
14. 3 (GPIIb-IIIa) receptor function. J. Biol. Chem. 269:20913-20919.
15. 3 subunit. J. Biol. Chem. 271:21978-21984.
16. 2 ligand interactions. J. Biol. Chem. 271:23729-23736.
17. 1 subunit. J. Biol. Chem. 271:20438-20443.
18. Springer, T.A. 1997. Folding of the N-terminal, ligand binding region of integrin α subunits into a β-propeller domain. Proc. Natl. Acad. Sci. USA. 94: 65-72.
19. 3 (glycoprolein IIb-IIIa) alter receptor affinity, specificity, and function. J. Biol. Chem. 266: 17106-17111.
20. Sims, P.J., M.H. Ginsberg, E.F. Plow, and S.J. Shattil. 1991. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J. Biol. Chem. 266:7345-7352.
21. Kouns, W.C., P. Hadvary, P. Haering, and B. Steiner. 1992. Conformational modulation of purified glycoprotein GPIIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa. J. Biol. Chem. 267:18844-18851.
22. Lee, J.-O., L.A. Bankslon, M.A. Arnaout, and R.C. Liddinglon. 1995. Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure (Lond.). 3:1333-1340.
23. Qu, A., and D.J. Leahy. 1996. The role of the divalent cation in the structure of the I domain from the CD11a/CD 18 integrin. Structure (Lond.). 4: 931-942.
24. Faull, R.J., and M.H. Ginsberg. 1995. Dynamic regulation of integrins. Stem Cells (Basel). 13:38-46.
25. 3 subunit is sensitive to stimulation. J. Biol. Chem. 266:14202-14207.
26. Shattil, S.J., J.A. Hoxie, M. Cunningham, and L.F. Brass. 1985. Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J. Biol. Chem. 260:11107-1114.
27. Lambright, D., J. Sondek, A. Bohm, N. Skiba, H. Hamm, and P. Sigler. 1996. The 2.0 Å crystal structure of a heterotrimeric G-protein. Nature (Lond.). 379:311-319.
28. Leahy, DJ., I. Aukhil, and H.P. Erickson. 1996. 2.0 Åcrystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and the synergy region. Cell. 84:155-164.
29. Zhang, L., and E.F. Plow. 1996. A discrete site modulates activation of I domains. J. Biol. Chem. 271:29953-29957.
30. 3 subunit: cation displacement is involved in ligand binding. Cell. 70:659-667.
31. Monod, J., J. Wyman, and J.-P. Changeux. 1963. Allosteric sytems and cellular control systems. J. Mol. Biol. 6:306-329.
32. Hughes, P., F. Diaz-Gonzalez, L. Leong, C. Wu, J. McDonald, S.J. Shattil, and M.H. Ginsberg. 1996. Breaking the integrin hinge. J. Biol. Chem. 271: 6571-6574.
33. Hughes, P.E., T.E. O'Toole, J. Ylanne, S.J. Shattil, and M.H. Ginsberg. 1995. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J. Biol. Chem. 270:12411-12417.
34. 2 (LFA-1, CD11a/CD18) cytoplasmic domain/cytoskeletal interactions. J. Exp. Med. 181:315-326.