Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

EMBO Journal

Volumn 19, Issue 9, 2000, Pages 2008-2014

  Del Pozo, Miguel A ^a   Price, Leo S ^a,b   Alderson, Nazilla B ^a   Ren, Xiang Dong ^a,c   Schwartz, Martin Alexander ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Integrin; Membrane translocation; p21 activated kinase; Rac; Rho family GTPase

Indexed keywords

GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; MUTANT PROTEIN; PROTEIN KINASE; RAC PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL ADHESION; CELL CYCLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT;

ANIMALIA;

EID: 0034595381     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.9.2008     Document Type: Article

References (39)

1. Abo, A., Webb, M.R., Grogan, A. and Segal, A.W. (1994) Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane. Biochem. J., 298, 585-591.
2. Anand-Apte, B., Zetter, B.R., Viswanathan, A., Qui, R.G., Chen, J., Ruggieri, R. and Symons, M. (1997) Platelet-derived growth factor and fibronectin stimulated migration are differentially regulated by the Rac and extracellular signal regulated kinase pathways. J. Biol. Chem., 272, 30688-30692.
3. Bokoch, G.M., Bohl, B.P. and Chuang, T.H. (1994) Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. J. Biol. Chem., 269, 31674-31679.
4. Chong, L.D., Traynor-Kaplan, A., Bokoch, G.M. and Schwartz, M.A. (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell, 79, 507-513.
5. Choy, E., Chiu, V.K., Siletti, J., Feoktisov, M., Morimoto, T., Michaelson, D., Ivanov, I.E. and Phillips, M.R. (1999) Endomembrane trafficking of Ras: the CAAX motif targets proteins to the ER and Golgi. Cell, 98, 69-80.
6. Clark, E.A., King, W.G., Brugge, J.S. Symons, M. and Hynes, R.O. (1998) Integrin mediated signals regulatd by members of the Rho family of GTPases. J. Cell Biol., 142, 573-586.
7. Dalton, S.L., Scharf, E., Briesewitz, R., Marcantonio, E.E. and Assoian, R.K. (1995) Cell adhesion to extracellular matrix regulates the life cycle of integrins. Mol. Biol. Cell, 6, 1781-1791.
8. Dharmawardhane, S., Sanders, L.C., Martin, S.S., Daniels, R.H. and Bokoch, G.M. (1997) Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J. Cell Biol., 138, 1265-1278.
9. Fleming, I.N., Elliot, C.M. and Exton, J.H. (1996) Differential translocation of Rho family GTPases by lysophosphatidic acid, endothelin-1 and platelet derived growth factor. J. Biol. Chem., 271, 33067-33073.
10. Glaven, J.A., Whitehead, I., Bagrodia, S., Kay, R. and Cerione, R.A. (1999) The DbI-related protein Lfc localizes to microtubules and mediates the activation of Rac signaling pathways in cells. J. Biol. Chem., 274, 2279-2285.
11. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science, 279, 509-514.
12. Jones, J.I., Doerr, M.E. and Clemmons, D.R. (1995) Cell migration: interactions among integrins, IGFs and IGFBPs. Prog. Growth Factor Res., 6, 319-327.
13. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H. and Downward, J. (1997) Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J., 16, 2783-2793.
14. Klemke, R.L., Yebra, M., Bayna, E.M. and Cheresh, D.A. (1994) Receptor tyrosine kinase signaling required for integrin αvβ5-directed cell motility but not adhesion on vitronectin. J. Cell Biol., 127, 859-866.
15. Knaus, U.G. and Bokoch, G.M. (1998) The p21Rac/Cdc42-activated kinases (PAKs). Int. J. Biochem. Cell Biol., 30, 857-862.
16. Lin, T.H., Chen, Q., Howe, A. and Juliano, R.L. (1997) Cell anchorage permits efficient signal transduction between ras and its downstream kinases. J. Biol. Chem., 272, 8849-8852.
17. Lu, W., Katz, S., Gupta, R. and Mayer, B.J. (1997) Activation of Pak by membrane localization mediated by an SH3 domain from the adapter protein Nck. Curr. Biol., 7, 85-94.
18. Mackay, D.J. and Hall, A. (1998) Rho GTPases. J. Biol. Chem., 273, 20685-20688.
19. McNamee, H.M., Ingber, D.E. and Schwartz, M.A. (1993) Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol., 121, 673-678.
20. 2-terminal kinase activity. J. Cell Biol., 137, 387-398.
21. Miyamoto, S., Teramoto, H., Gutkind, J.S. and Yamada, K.M. (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol., 135, 1633-1642.
22. Mohr, C., Just, I., Hall, A. and Aktories, K. (1990) Morphological alterations of Xenopus oocytes induced by valine-14 p21Rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase. FEBS Lett., 275, 168-172.
23. Nobes, C.D. and Hall, A. (1995) Rho, Rac and Cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell, 81, 53-62.
24. Nobes, C.D. and Hall, A. (1999) Rho GTPases control polarity, protrusion and adhesion during cell movement. J. Cell Biol., 144, 1235-1244.
25. Nomanbhoy, T.K., Erickson, J.W. and Cerione, R.A. (1999) Kinetics of Cdc42 membrane extraction by Rho-GDI monitored by real-time fluorescence resonance energy transfer. Biochemistry, 38, 1744-1750.
26. 1. Science, 269, 1270-1272.
27. Plopper, G.E., McNamee, H.P., Dike, L.E., Bojanowski, K. and Ingber, D.E. (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol. Biol. Cell, 6, 1349-1365.
28. Price, L.S., Leng, J., Schwartz, M.A. and Bokoch, G.M. (1998) Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol. Biol. Cell, 9, 1863-1871.
29. Qiu, M.-S., Pitts, A.F., Winter, T.R. and Green, S.H. (1991) Ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation in PC12 cells. J. Cell Biol., 115, 795-808.
30. Qiu, R.G., Chen, J., Kirn, D., McCormick, F. and Symons, M. (1995) An essential role for Rac in Ras transformation. Nature, 374, 457-459.
31. Renshaw, M.W., Ren, X.D. and Schwartz, M.A. (1997) Activation of the MAP kinase pathway by growth factors requires integrin-mediated cell adhesion. EMBO J., 16, 5592-5599.
32. Ridley, A.J. and Hall, A. (1992) The small GTP binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell, 70, 389-399.
33. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. and Hall, A. (1992) The small GTP-binding protein rac regulates growth factor induced membrane ruffling. Cell, 70, 401-410.
34. Schwartz, M.A. (1997) Integrins, oncogenes and anchorage independence. J. Cell Biol., 139, 575-578.
35. Schwartz, M.A. and Baron, V. (1999) Interactions between mitogenic stimuli, or, a thousand and one connections. Curr. Opin. Cell Biol., 11, 197-202.
36. Short, S.M., Talbott, G.A. and Juliano, R.L. (1998) Integrin-mediated signaling events in human endothelial cells. Mol. Biol. Cell, 9, 1969-1980.
37. Stoker, M., O'Neill, C., Berryman, S. and Waxman, V. (1968) Anchorage and growth regulation in normal and virus-transformed cells. Int. J. Cancer, 3, 683-693.
38. Wary, K.K., Maneiro, F., Isakoff, S.J., Marcantonio, E.E. and Giancotti, F.G. (1996) The adapter protein She couples a class of integrins to the control of cell cycle progression. Cell, 87, 733-743.
39. Westwick, J.K., Lambert, Q.T., Clark, G.J., Symons, M., VanAelst, L., Pestell, R.G. and Der, C.J. (1997) Rac regulation of transformation, gene expression and actin organization by multiple PAK-independent pathways. Mol. Cell. Biol., 17, 1324-1335.