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Binding of the cytoplasmic domain of intercellular adhesion molecule-2 (ICAM-2) to ́-actinin
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Li R, Xie J, Kantor C, Koistinen V, Altieri DC, Nortamo P, Gahmberg CG: A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18. J Cell Biol 1995, 129:1143-1153.
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An ICAM-related neurone glycoprotein, telencephalin, with brain segment-specific expression
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cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymhocyte function-associated antigen-1
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The neuronal glycoprotein telenchephalin is a cellular ligand for the CD11a/CD18 leukocyte integrin
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Tian L, Yoshihara Y, Mizuno T, Mori K, Gahmberg CG: The neuronal glycoprotein telenchephalin is a cellular ligand for the CD11a/CD18 leukocyte integrin. J Immunol 1997, 158:928-936. The binding of telencephalin to CD11a/CD18 was demonstrated. Telencephalin is the first brain-specific ICAM molecule, and intriguing questions are raised about its possible functions.
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0029796372
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Identification of an active sequence within the first immunoglobulin domain of intercellular cell adhesion molecule-1 (ICAM-1) that interacts with fibrinogen
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D'Souza, S.E.1
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Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated 1
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0029845205
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Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1)
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Casasnovas JM, Springer TA, Liu J-H, Harrison SC, Wang J-H: Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. Nature 1997, 387:312-315. Here, for the first time, the three-dimensional structure of the external part of an ICAM molecule is described. The binding region for integrins is rather flat and this region lacks the protruding loop seen in VCAM-1; this region is probably important for binding. In contrast to the first domains of ICAM-2 and VCAM-1 which are rather different, probably reflecting different functions, the second domains are quite similar.
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Van Kooyk Y, Binnerts ME, Edwards CP, Champe M, Berman PW, Figdor CG, Bodary SC: Critical amino acids in the lymphocyte function-associated antigen-1 I domain mediate intercellular adhesion molecule 3 binding and immune function. J Exp Med 1996, 183:1247-1252.
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0029971322
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Antibodies that selectively inhibit leukocyte function-associated antigen 1 binding to intercellular adhesion molecule-3 recognize a unique epitope within the CD11a I-domain
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Binnerts ME, van Kooyk Y, Edwards CP, Champe M, Presta L, Bodary SC, Figdor CG, Berman PW: Antibodies that selectively inhibit leukocyte function-associated antigen 1 binding to intercellular adhesion molecule-3 recognize a unique epitope within the CD11a I-domain. J Biol Chem 1996, 271:9962-9968.
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Identifying the putative metal ion-dependent adhesion site in the β2 (CD18) subunit required for αLβ2 and αMβ2 ligand interactions
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Goodman TG, Bajt ML: Identifying the putative metal ion-dependent adhesion site in the β2 (CD18) subunit required for αLβ2 and αMβ2 ligand interactions. J Biol Chem 1996, 271:23729-23736.
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Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
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Springer TA: Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain. Proc Natl Acad Sci USA 1997, 94:65-72. The proposal is made that the amino-terminal part of an integrin a subunit forms a β-propeller-like structure, which may resemble G proteins. Although still hypothetical, this proposal is interesting and certainly stimulates research on this topic.
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Folding of the conserved domain but not of flanking regions in the integrin β2 subunit requires association with the α subunit
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Huang C, Lu C, Springer TA: Folding of the conserved domain but not of flanking regions in the integrin β2 subunit requires association with the α subunit. Proc Natl Acad Sci USA 1997, 94:3156-3161. In this paper and [39], monoclonal antibodies were used to probe the folding of CD18 and CD11a polypeptides during integrin biosynthesis.
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Huang, C.1
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0030940890
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Folding of the β-propeller domain of the integrin αL subunit is independent of the I domain and dependent on the β2 subunit
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Huang C, Springer TA: Folding of the β-propeller domain of the integrin αL subunit is independent of the I domain and dependent on the β2 subunit Proc Natl Acad Sci USA 1997, 94:3162-3167.
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0029875796
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A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice
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Bullard DC, Scharffetter-Kochanek K, McArthur MJ, Chosay JG, McBride ME, Montgomery CA, Beaudet AL: A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice. Proc Natl Acad Sci USA 1996, 93:2116-2121. Homozygous 129/Sv mice lacking the CD18 gene showed, as expected, a number of defects in leukocyte functions. However, when mice of this strain were backcrossed into the PL/J strain, the next generation mice developed a psoriasis-like skin disease. The finding shows the importance of CD11/CD18 integrins but also that other gene products are involved in the development of this skin disease.
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Proc Natl Acad Sci USA
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Bullard, D.C.1
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41
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A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation
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Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Amaout MA, Mayadas TN: A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 1996, 5:653-666. This paper describes results that indicate an important role of CD11b/CD18 in apoptosis.
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A novel leukointegrin, αdβ2, binds preferentially to ICAM-3
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Van der Vieren M, Le Trong H, Wood CL, Moore PF, St John T, Staunton DE, Gallatin WM: A novel leukointegrin, αdβ2, binds preferentially to ICAM-3. Immunity 1995, 3:683-690.
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