Metabolism of Presenilins

Journal of Molecular Neuroscience

Volumn 17, Issue 2, 2001, Pages 183-192

  Thinakaran, G ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amyloid precursor protein; Familial Alzheimer's disease; Presenilin; Proteolysis; PS1; PS2

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MEMBRANE PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENETIC CODE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; SEQUENCE HOMOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CASPASES; CATALYTIC DOMAIN; HUMANS; MEMBRANE PROTEINS; PEPTIDE HYDROLASES; PRESENILIN-1; PRESENILIN-2;

ANIMALIA;

EID: 0035169484     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:17:2:183     Document Type: Article

References (70)

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4. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
5. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch
6. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in-both transfected cells and transgenic mice
7. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
8. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
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11. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family
12. Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling
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14. Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls
15. Dual roles of proteasome in the metabolism of presenilin 1
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17. Presenilin 1 facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway
18. Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
19. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
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25. Membrane topology of the C. elegans SEL-12 presenilin
26. Photoactivated gammasecretase inhibitors directed to the active site covalently label presenilin 1
27. Presenilins are processed by caspase-type proteases
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29. Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A
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33. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin
34. A loss of function mutant of the presenilin homologue sel-12 undergoes abberant endoproteolysis in Caenorhabditis elegans and increased A-beta-42 generation in human cells
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38. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
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41. Evidence that intramolecular associations between Presenilin domains are obligatory for endoproteolytic processing
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55. Stable association of presenilin derivatives and absence of presenilin interactions with APP
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