Absence of endoproteolysis but no effects on amyloid β production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A

Molecular Brain Research

Volumn 85, Issue 1-2, 2000, Pages 85-90

  Morihara, Takashi ^a,b   Katayama, Taiichi ^a,b   Sato, Naoya ^a,b   Yoneda, Takunari ^a,b   Manabe, Takayuki ^a,b   Hitomi, Junichi ^a,b   Abe, Hirohito ^a   Imaizumi, Kazunori ^a,b   Tohyama, Masaya ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Secretase activity; Alternative splicing; Alzheimer's disease; Amyloid ; Endoproteolysis; Presenilin 1

Indexed keywords

AMINO ACID; AMYLOID BETA PROTEIN; GAMMA SECRETASE; PRESENILIN 1; PROTEIN;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXON; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; WESTERN BLOTTING;

ALTERNATIVE SPLICING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; EXONS; HUMANS; MEMBRANE PROTEINS; MICE; NEUROBLASTOMA; NEURONS; PLASMIDS; PRESENILIN-1; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034727882     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00229-1     Document Type: Article

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