Zebrafish (Danio rerio) presenilin promotes aberrant amyloid β-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

Biochemistry

Volumn 38, Issue 41, 1999, Pages 13602-13609

  Leimer, Uwe ^a   Lun, Klaus ^b   Romig, Helmut ^c   Walter, Jochen ^a   Grünberg, Jürgen ^a   Brand, Michael ^b   Haass, Christian ^a,d  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ASPARTIC ACID; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ARTICLE; ENZYME ACTIVITY; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; ZEBRA FISH;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; ASPARTIC ACID; CELL LINE; CONSERVED SEQUENCE; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; ZEBRAFISH;

DANIO RERIO;

EID: 0033550061     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991453n     Document Type: Article

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