Different effects of Alzheimer-associated mutations of presenilin 1 on its processing

Neuroscience Letters

Volumn 229, Issue 1, 1997, Pages 61-64

  Murayama, Ohoshi ^a   Honda, Toshiyuki ^a   Mercken, Marc ^a   Murayama, Miyuki ^a   Yasutake, Kaori ^a   Nihonmatsu, Naomi ^a   Nakazato, Yuko ^a   Michel, Gilles ^a   Song, Shaochuen ^a   Sato, Kazuki ^a   Takahashi, Hiroshi ^a   Takashima, Akihiko ^a  

^a MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

Author keywords

Familial Alzheimer's disease; Mutations; PC12 cells; Presenilin 1; Processing; Transfection

Indexed keywords

CELL PROTEIN; PRESENILIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; GLIOMA CELL; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; HUMANS; MEMBRANE PROTEINS; PC12 CELLS; POINT MUTATION; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; TRANSFECTION;

EID: 0030832449     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00417-5     Document Type: Article

References (13)

1. Borchelt, D.R., Thinakaran, G., Eckman, C.B., Lee, M.K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., Slunt, H.H., Wang, R., Seeger, M., Levey, A.I., Gandy, S.E., Copeland, N.G., Jenkins, N.A., Price, D.L., Younkin, S.G. and Sisodia, S.S., Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo, Neuron, 17 (1996) 1005-1013.
2. Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P. and St. George-Hyslop, P., Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice, Nature Med., 3 (1997) 67-72.
3. Crutz, M., Hendriks, L. and Broeckhoven, C.V., The presenilin genes: a new gene family involved in Alzheimer disease pathology, Hum. Mol. Genet., 5 (1996) 1449-1455.
4. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Perez-tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M.N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J. and Younkin, S., Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1, Nature, 383 (1996) 710-713.
5. Grunberg, W.J., Capell, A., Pesold, B., Schinzielorz, A., Citron, M., Mendla, K., George-Hyslop, P.S., Multhaup, G., Selkoe, D.J. and Haas, C., Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C, Proc. Natl. Acad. Sci. USA, 94 (1997) 5349-5354.
6. Koike, T. and Takashima, A., Clonal variability of PC12 pheochromocytoma cells with respect to catecholamine biosynthesis, J. Neurochem., 42 (1984) 1472-1475.
7. Kovacs, D.M., Fausett, H.J., Page, K.J., Kim, T.-W., Moir, R.D., Merriam, D.E., Hollister, R.D., Hallmark, O.G., Mancini, R., Felsenstein, K.M., Hyman, B.T., Tanzi, R.E. and Wasco, W., Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells, Nature Med., 2 (1996) 224-229.
8. Mercken, M., Takahashi, H., Honda, T., Sato, K., Murayama, M., Nakazato, Y., Noguchi, K., Imahori, K. and Takashima, A., Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: evidence that Alzheimer mutation affect proteolytic processing, FEBS Lett., 389 (1996) 297-303.
9. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T.D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lanfelt, L., Selkoe, D. and Younkin, S., Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease, Nature Med., 2 (1996) 864-870.
10. Seeger, M., Norstedt, C., Petanceska, S., Kovacs, D.M., Gouras, G.K., Hahne, S., Fraser, P., Levesque, L., Czernik, A.J., George-Hyslop, P.S., Sisodia, S.S., Thinakaran, G., Tanzi, R.E., Greengard, P. and Gandy, S., Evidence for phosphorylation and oligomeric assembly of presenilin 1, Proc. Natl. Acad. Sci. USA, 94 (1997) 5090-5094.
11. Takashima, A., Sato, M., Mercken, M., Tanaka, S., Kondo, S., Honda, T., Sato, K., Murayama, M., Noguchi, K., Nakazato, Y. and Takahashi, H., Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells, Biochem. Biophys. Res. Commun., 227 (1996) 423-426.
12. Thinakaran, G., Borchelt, D.R., Lee, M.K., Slunt, H.H., Spitzer, L., Kim, G., Ratovisky, T., Davenport, F., Norstedt, C., Seeger, M., Hardy, J., Levey, A.I., Gandy, S.E., Jenkins, N.A., Copeland, N.G., Price, D.L. and Sisodia, S.S., Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo, Neuron, 17 (1996) 181-190.
13. Van Broeckhoven, C., Presenilins and Alzheimer disease, Nature Genet., 11 (1995) 230-232.