Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

FEBS Letters

Volumn 389, Issue 3, 1996, Pages 297-303

  Mercken, Marc ^a   Takahashi, Hiroshi ^a   Honda, Toshiyuki ^b   Sato, Kazuki ^a   Murayama, Miyuki ^a   Nakazato, Yuko ^a   Noguchi, Kaori ^a   Imahori, Kasutomo ^a   Takashima, Akihiko ^a  

^a Mitubishi Kasei Inst of Life Sci   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Alzheimer disease; Chromosome 14; Monoclonal antibody; Presenilin; Proteolysis

Indexed keywords

EPITOPE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 14; CONTROLLED STUDY; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MISSENSE MUTATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING;

EID: 0030575338     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(96)00608-4     Document Type: Article

References (22)

1. [1] Mann, D.M.A. (1995) in: Research Advances in Alzheimer's Disease and Related Disorders (Iqbal, K. et al. eds.) Wiley, Chichester.
2. [2] Goate, A., Chartier-Hirlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M., Roses, A., Williamson, R., Rossor, M., Owen, M. and Hardy, J. (1991) Nature 349, 704-706.
3. [3] Strittmatter, J.W. and Roses, A.D. (1995) Proc. Natl. Acad. Sci. USA 92, 4725-4727.
4. [4] Van Broeckhoven, C. (1995) Nat. Genet 11, 230-232.
5. [5] Sherrington, R., Rogaev, E.I., Lianag, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.-F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Da Silva, H.A.R., Haines, J.L., Pericak-Vance, M.A., Roses, A.D., Fraser, P.E., Rommens, J.M. and St George-Hyslop, P.H. (1995) Nature 375, 754-760.
6. [6] Alzheimer's Disease Collaborative Group (1995) Nat. Genet. 11, 219-222.
7. [7] Campion, D., Flaman, J.-M., Brica, A., Hannequin, D., Dubois, B., Martin, C., Moreau, V., Charbonnier, F., Didierjean, F., Tardieu, S., Penet, C., Puel, M., Pasquier, F., Le Doze, F., Bellis, G., Calenda, A., Heilig, R., Martinez, M., Mallet, J., Bellis, M., Clerget-Darpoux, F., Agid, Y. and Frebourg, T. (1995) Hum. Mol. Genet. 4, 2373-2377.
8. [8] Tanahashi, H., Mitsunaga, Y., Takahashi, K., Tasaki, H., Watanabe, S. and Tabira, T. (1995) Lancet 346, 440.
9. [9] Cruts, M., Backhovens, H., Wang, S.-Y., Van Gassen, G., Theuns, J., De Jonghe, C., Wehnert, A., De Voecht, J., De Winter, G., Cras, P., Bruyland, M., Datson, N., Weissenbach, J., Den Dunnen, J.T., Martin, J.-J., Hendriks, L. and Van Broeckhoven, C. (1995) Hum. Mol. Genet. 4, 2363-2371.
10. [10] Sorbi, S., Nacmias, B., Forleo, P., Piacentini, S., Sherrington, R., Rogaev, E., Hyslop, P.S.G. and Amaducci, L. (1995) Lancet 346, 439-440.
11. [11] Wasco, W., Pettingell, W.P., Jondro, P.D., Schmidt, S.D., Gurubhagavatula, S., Rodes, L., DiBlasi, T., Romano, D.M., Guenette, S.Y., Kovacs, D.M., Growdon, J.H. and Tanzi, R.E. (1995) Nat. Med. 1, 848.
12. [12] Rogaev, E.I., Sherrington, R., Rogaeva, E.A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, L, Cohen, D., Lannfelt, L., Fraser, P.E., Rommens, J.M. and St George-Hyslop, P.H. (1995) Nature 376, 775-778.
13. [13] Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D.M., Oshima, J., Pettingell, W.H., Yu, C., Jondro, P.D., Schmidt, S.D., Wang, K., Crowley, A.C., Fu, Y.-H., Guenette, S.Y., Galas, D., Nemens, E., Wijsman, E.M., Bird, T.D., Schellenberg, G.D., Tanzi, R.E. (1995) Science 269, 973-977.
14. [14] Perez-Tur, J., Froelich, S., Prihar, G., Crook, R., Baker, M., Duff, K., Wragg, M., Busfield, F., Lendon, C., Clark, R.F., Roques, P., Fuldner, R.A., Johnston, J., Cowburn, R., Forsell, C., Axelman, K., Lilius, L., Houlden, H., Karran, E., Roberts, G.W., Rossor, M., Adams, M.D., Hardy, J., Goate, A., Lannfelt, L. and Hutton, M. (1995) NeuroReport 7, 297-301.
15. [15] Wragg, M., Hutton, M., Talbot, C. and the Alzheimer's Disease Collaborative Group (1996) Lancet 347, 509-512.
16. [16] Mercken, M., Vandermeeren, M., Lubke, U., Six, J., Boons, J., Van de Voorde, A., Martin, J.-J. and Gheuens, J. (1992) Acta Neuropathol. 84, 265-272.
17. [17] Kim, D.W., Uetsuki, T., Kaziro, Y., Yamaguchi, N. and Sugano, S. (1990) Gene 91, 217-223.
18. [18] Ito, K. (1984) Mol. Gen. Genet. 197, 204-208.
19. [19] Sahara, N. Yahagi, Y., Takagi, H., Kondo, T., Okochi, M., Usami, M., Shirasawa, T. and Mori, H. (1996) FEBS Lett. 381, 7-11.
20. [20] Ehring, R., Beyreuther, K., Wright, J.K. and Overath, P. (1980) Nature 283, 537-540.
21. [21] Wisniewski, T., Palha, J.O., Ghiso, J. and Frangione, B. (1995) Lancet 346, 1366.
22. [22] Kovacs, D.M., Fausett, H.F., Page, K.J., Kim, T.-W., Moir, R.D., Merriam, D.E., Hollister, R.D., Hallmark, O.G., Mancini, R., Felsenstein, K.M., Hyman, B.T., Tanzi, R.E. and Wasco, W. (1995) Nat. Med 2, 224-229.