Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

NeuroReport

Volumn 11, Issue 14, 2000, Pages 3227-3230

  Dong Mei Zhang, ^a   Levitan, D ^a   Yu, G ^a   Nishimura, M ^a   Chen, F ^a   Tandon, A ^a   Kawarai, T ^a   Arawaka, S ^a   Supala, A ^a   Song, Y Q ^a   Rogaeva, E ^a   Liang, Y ^a   Holmes, E ^a   Milman, P ^a   Sato, C ^a   Zhang, L ^a   St George Hyslop, P ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Alzheimer disease; A ; Development; lin 12; Notch; Presenilin; Sel 12; amyloid precursor protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CYSTEINE; MEMBRANE PROTEIN; NOTCH RECEPTOR; PRESENILIN 1;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MAMMAL CELL; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 0034727409     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200009280-00035     Document Type: Article

References (28)