Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin

Molecular and Cellular Neurosciences

Volumn 15, Issue 1, 2000, Pages 88-98

  Nowotny, Petra ^a   Gorski, Sharon M ^a   Han, Sang Woo ^a   Philips, Kacy ^a   Ray, William J ^a   Nowotny, Volker ^a   Jones, Christopher J ^b   Clark, Robert F ^b   Cagan, Ross L ^a   Goate, Alison M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ARTICLE; CELL MEMBRANE; DROSOPHILA MELANOGASTER; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 17544390088     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1999.0805     Document Type: Article

References (48)

1. Baumeister R., Leimer U., Zweckbronner I., Jakubek C., Grunberg J., Haass C. Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct. 1:1997;149-159.
2. Berezovska O., Xia M. Q., Hyman B. T. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J. Neuropathol. Exp. Neurol. 57:1998;738-745.
3. Borchelt D., Thinakaran G., Eckman C., Lee M., Davenport F., Ratovitsky T., Prada C.-M., Kim G., Seekins S., Yager D., Slunt H., Wang R., Seeger M., Levey A., Gandy S., Copeland N., Jenkins N., Price D., Younkin S., Sisodia S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
4. Boulianne G. L., Livne-Bar I., Humphreys J. M., Liang Y., Lin C., Rogaev E., St. George-Hyslop P. Cloning and characterization of the Drosophila presenilin homologue. NeuroReport. 8:1997;1025-1029.
5. Cagan R., Ready D. The emergence of order in the Drosophila pupal retina. Dev. Biol. 136:1989a;346-362.
6. Cagan R., Ready D. Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 3:1989b;1099-1112.
7. Cruts M., Hendriks L., Van Broeckhoven C. The presenilin genes: A new gene family involved in Alzheimer disease pathology. Hum. Mol. Genet. 5:1996;1449-1455.
8. De Strooper B., Saftig P., Crassaerts K., Vanderstichele H., Guhde G., Annart W., Van Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391:1998;387-390.
9. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J. S., Schroeter E. H., Schrijvers V., Wolfe M. S., Ray W. J., Goate A., Kopan R. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522.
10. Doan A., Thinakaran G., Borchelt D., Slunt H., Ratovitsky T., Polinsky R., Selkoe D., Seeger M., Gandy S., Price D., Sisodia S. Protein topology of presenilin 1. Neuron. 17:1996;1023-1030.
11. Duff K., Eckman C., Zehr C., Yu X., Prada C.-M., Perez-Tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M. N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
12. Fehon R. G., Kooh P. J., Rebay I., Regan C. L., Xu T., Muskavitch M. A. T., Artavanis-Tsakonas S. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 61:1990;523-534.
13. Fehon R. G., Johansen K., Rebay I., Artavanis-Tsakonas S. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: Implications for Notch function. J. Cell Biol. 113:1991;657-669.
14. Goate A., Chartier-Harlin M. C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Mant R., Newton P., Rooke K., Roques P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen M., Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
15. Hong C.-S., Koo E. H. Isolation and characterization of Drosophila presenilin homolog. NeuroReport. 8:1997;665-668.
16. Kooh P. J., Fehon R. G., Muskavitch M. A. T. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development. 117:1993;493-507.
17. Kovacs D. M., Fausett H. J., Page K., Kim T.-W., Moir R. D., Merriam D. E., Hollister R. D., Hallmark O. G., Mancini R., Felsenstein K. M., Hyman B. T., Tanzi R., Wasco W. Alzheimer-associated presenilin 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2:1996;224-229.
18. Lah J. J., Heilman C. J., Nash N. R., Rees H. D., Yi. H., Counts S. E., Levey A. I. Light and electron microscopic localization of presenilin-1 in primate brain. J. Neurosci. 17:1997;1971-1980.
19. Levitan D., Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature. 377:1995;351-354.
20. Levitan D., Doyle T. G., Brousseau D., Lee M. K., Thinakaran G., Slunt H. H., Sisodia S. S., Greenwald I. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 93:1996;14940-14944.
21. Levy-Lahad E., Wasco W., Poorkaj P., Romano D., Oshima J., Pettingell W., Yu C., Jondro P., Schmidt S., Wang K., Crowley A., Fu Y.-H., Guenette S., Galas D., Nemens E., Wijsman E., Bird T., Schellenberg G., Tanzi R. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269:1995a;973-977.
22. Levy-Lahad E., Wijsman E., Nemens E., Anderson L., Goddard K. A., Weber J. L., Bird T., Schellenberg G. A familial Alzheimer's disease locus on chromosome 1. Science. 269:1995b;970-973.
23. Li X., Greenwald I. Membrane topology of the C. elegans SEL-12 presenilin. Neuron. 17:1996;1015-1021.
24. Li X., Greenwald I. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. USA. 94:1997;12204-12209.
25. Marfany G., Del-Favero J., Valero R., De Jonghe C., Woodrow S., Hendriks L., Van Broeckhoven C., Gonzalez-Duarte R. Identification of a Drosophila presenilin homologue: Evidence of alternative spliced forms. J. Neurogenet. 12:1998;41-54.
26. Miller D. T., Cagan R. L. Local induction of patterning and programmed cell death in the developing Drosophila retina. Development. 125:1998;2327-2335.
27. Perez-Tur J., Froelich S., Prihar G., Crook R., Baker M., Duff K., Wragg M., Busfield F., Lendon C., Clark R. F., Roques P., Fuldner R. A., Johnston J., Cowburn R., Forsell C., Axelman K., Lilius L., Houlden H., Karran E., Roberts G. W., Rossor M., Adams M. D., Hardy J., Goate A., Lannfelt L., Hutton M. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. NeuroReport. 7:1995;297-301.
28. 299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol. Dis. 3:1997;325-337.
29. Prihar G., Fuldner R., Perez-Tur J., Lincoln S., Duff K., Crook R., Hardy J., Philips C. A., Venter C., Talbot C., Clark R. F., Goate A., Li J., Potter H., Karran E., Roberts G. W., Hutton M., Adams M. D. Structure and alternative splicing of the presenilin-2 gene. NeuroReport. 7:1996;1680-1684.
30. Ray W. J., Yao M., Nowotny P., Mumm J., Zhang W., Wu J. Y., Kopan R., Goate A. M. Evidence for a physical interaction between presenilin and Notch. Proc. Natl. Acad. Sci. USA. 96:1999;3263-3268.
31. Rogaev E. I., Sherrington R., Rogaeva E. A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., Mar L., Sorbi S., Nacmias B., Piacentinin S., Amaducci L., Chumakov I., Cohen D., Lannfelt L., Fraser P. E., Rommens J. M., St. George-Hyslop P. H. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376:1995;775-778.
32. Rogaev E. I., Sherrington R., Wu C., Levesque G., Liang Y., Rogaeva E. A., Ikeda M., Holman K., Lin C., Lukiw W. J., De Jong P. J., Fraser P. E., Rommens J. M., St. George-Hyslop P. Analysis of the 5′ sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics. 40:1997;415-424.
33. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
34. Schroeter E. H., Kisslinger J. A., Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 393:1998;381-386.
35. Schwarzman A. L., Singh N., Tsiper M., Gregori L., Dranovsky A., Vitek M. P., Glabe C. G., St. George-Hyslop P. H., Goldgraber D. Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. Proc. Natl. Acad. Sci. USA. 96:1999;7932-7937.
36. Seeger M., Norstedt C., Petanska S., Kovacs D. M., Gouras G., Hahne S., Fraser P., Levesque L., Czernik A., St. George-Hyslop P., Sisodia S., Thinakaran G., Tanzi R., Greengard P., Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. USA. 94:1997;5090-5094.
37. Shen J., Bronson R. T., Chen D. F., Xia W., Selkoe D. J., Tonekawa S. Skeletal and CNS defects in presenilin-1-deficient mice. Cell. 89:1997;629-639.
38. Sherrington R., Rogaev E., Liang Y., Rogaeva E., Levesque G., Ikeda M., Chi H., Lin C., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A., Montesi M., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R., Wasco W., da Silva H., Haines J., Pericak-Vance M., Tanzi R., Roses A., Fraser P., Rommens J., St. George-Hyslop P. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
39. Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell. 93:1998;649-660.
40. Struhl G., Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 398:1999;522-525.
41. Thinakaran G., Borchelt D., Lee M., Slunt H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Norstedt C., Seeger M., Hardy J., Levey A., Gandy S., Jenkins N., Copeland N., Price D., Sisodia S. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17:1996;181-190.
42. Thompson J. D., Higgins D. G., Gibson T. J. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:1994;4673-4680.
43. rd) residue. Proc. Natl. Acad. Sci. USA. 94:1997;2025-2030.
44. Wolfe M. S., Xia W., Moore C. L., Leatherwood D. D., Ostaszewski B. L., Rahmati T., Donkor I. O., Selkoe D. J. Peptidometic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 38:1999a;4720-4727.
45. Wolfe M. S., Xia W., Ostaszewski B. L., Diehl T. S., Kimberly W. T., Selkoe D. J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature. 398:1999b;513-517.
46. Wong P., Zheng, Chen H., Becker M., Sirinathsinghji D. J. S., Trumbauer M. E., Chen H. Y., Price D. L., Van der Ploeg L. H. T., Sisodia S. Presenilin is required for Notch 1 and Dll 1 expression in the paraxial mesoderm. Nature. 387:1997;288-291.
47. Ye Y., Fortini M. E. Characterization of Drosophila Presenilin and its colocalization with Notch during development. Mech. Dev. 79:1998;199-211.
48. Ye Y., Lukinova N., Fortini M. E. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 398:1999;525-529.