Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

NeuroReport

Volumn 9, Issue 7, 1998, Pages 1481-1486

  Brockhaus, Manfred ^a   Grünberg, Jürgen ^b   Röhrig, Sascha ^c   Loetscher, Hansruedi ^a   Wittenburg, Nicole ^c   Baumeister, Ralf ^c   Jacobsen, Helmut ^a   Haass, Christian ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c Genzentrum   (Germany)

Author keywords

Alzheimer's disease; Amyloid peptide; Caspases; Death substrates; NOTCH signaling; Presenilin; Proteolytic processing; Sel 12

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

EID: 0032507667     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-199805110-00043     Document Type: Article

References (24)

1. Selkoe DJ. J Biol Chem 271, 18296-18298 (1996).
2. Burdick D, Soreghan B and Kwon M. J Biol Chem 267, 546-554 (1992).
3. Sherrington R, Rogaev EI, Liang Y et al. Nature 375, 754-760 (1995).
4. Haass C. Neuron 18, 687-690 (1997).
5. Levy-Lahad E, Wasco W, Poorkaj P et al. Science 269, 973-977 (1995).
6. Rogaev EI, Sherrington R, Rogaeva EA et al. Nature 376, 775-778 (1995).
7. Doan A, Thinakaran G, Borchelt DR et al. Neuron 17, 1023-1030 (1996).
8. De Strooper B, Beullens M, Contreras B et al. J Biol Chem 272, 3590-3598 (1997).
9. Levitan D, Doyle T, Brousseau D et al. Proc Natl Acad Sci USA 93, 14940-14944 (1996).
10. Baumeister R, Leimer U, Zweckbronner I et al. Genes Function 1, 149-159 (1997).
11. Shen J, Bronson RT, Chen DF et al. Cell 89, 629-639 (1997).
12. Wong PC, Zheng H, Chen H et al. Nature 387, 288-292 (1997).
13. Thinakaran G, Borchelt DR, Lee MK et al. Neuron 17, 181-190 (1998).
14. Mercken M, Takahashi H, Honda T et al. FEBS Lett 389, 297-303 (1995).
15. Thinakaran G, Regard JB, Bouton CM et al. Neurobiol Dis in press.
16. Capell, A, Grünberg, J, Pesold B et al. J Biol Chem 37, 2263-2270 (1998).
17. Kim T-W, Pettingell WH, Jung Y-K et al. Science 277, 373-376 (1997).
18. Loetscher H, Deuschle U, Brockhaus M et al. J Biol Chem 272, 20655-20659 (1997).
19. Grünberg J, Walter J, Loetscher H et al. Biochemistry 273, 3205-3211 (1998).
20. Vito PV, Ghayur T and D'Adamio LD. J Biol Chem 272, 28315-28320 (1997).
21. Jacobson MD, Weil M and Raff MC. Cell 88, 347-354 (1997).
22. Hobert O, Mori I, Yamashita Y et al. Neuron 19, 345 (1997).
23. Li X and Greenwald I. Neuron 17, 1015-1021 (1996).
24. Holtzman DM and Deshmukh M. Nature Med 3, 954-955 (1997).