Endothelium-derived relaxing factors: A focus on endothelium-derived hyperpolarizing factor(s)

Canadian Journal of Physiology and Pharmacology

Volumn 79, Issue 6, 2001, Pages 443-470

  McGuire, J J ^a   Ding, H ^a   Triggle, C R ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Endothelium; Gap junctions; Hyperpolarization; Nitric oxide; Potassium channels

Indexed keywords

ADENOSINE; ANANDAMIDE; CANNABINOID; CITRULLINE; CYCLIC AMP; CYCLIC GMP; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; EPOXYICOSATRIENOIC ACID; HYDROGEN PEROXIDE; NITRIC OXIDE; POTASSIUM CHANNEL; POTASSIUM ION; PROSTACYCLIN; VASODILATOR AGENT;

ANGIOGENESIS; ATHEROSCLEROSIS; CELL COMMUNICATION; CELL FUNCTION; CELL SPECIFICITY; ENDOTHELIUM CELL; GAP JUNCTION; HUMAN; HYPERPOLARIZATION; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0034885499     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y01-025     Document Type: Review

References (274)

1. Ion channels and regulation of intracellular calcium in vascular endothelial cells
2. +]: A functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed
3. Control of gap junction formation in canine trachea by arachidonic acid metabolites
4. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide
5. Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation
6. Expression and localization of CYP3A4 and CYP3A5 in human lung
7. Ca channel activity
8. Functional role of high-affinity anandamide transport, as revealed by selective inhibition
9. Bidirectional electrical communication between smooth muscle and endothelial cells in the pig coronary artery
10. Hydrogen peroxide: An endogenous smooth muscle cell hyperpolarizing factor
11. The role of adenosine in the regulation of coronary blood flow
12. Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue
13. Arachidonic acid amide inhibitors of gap junction cell-cell communication
14. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
15. 2+ changes and dilation in isolated resistance arteries
16. + channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with cholecalciferol
17. ir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells
18. Regulation of arterial tone by activation of calcium-dependent potassium channels
19. Gap junction voltage dependence: A clear picture emerges
20. Mechanisms of nitric oxide release from the vascular endothelium
21. Hydrogen peroxide, potassium currents, and membrane potential in human endothelial cells
22. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone
23. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal AA epoxygenase
24. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
25. Cytochrome P-450-dependent HETEs: Profile of biological activity and stimulation by vasoactive peptides
26. Voltage-gated potassium channels, their electrophysiology and function
27. Epoxyeicosatrienoic acids, potassium channel blockers and endothelium-dependent hyperpolarization in the guinea-pig carotid artery
28. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries
29. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries
30. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries
31. The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication
32. Characterization of acetyl-choline-induced membrane hyperpolarization in endothelial cells
33. Modulation of endothelium-dependent hyperpolarization and relaxation to acetylcholine in rat mesenteric artery by cytochrome P450 enzyme activity
34. Calcium dependency of the endothelium-dependent hyperpolarization in smooth muscle cells of the rabbit carotid artery
35. Endothelium-dependent hyperpolarization elicited by adenine compounds in rabbit carotid artery
36. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels
37. Membrane potential of vascular smooth muscle and hypertension in spontaneously hypertensive rats
38. Regulation of vascular tone by endothelium-derived hyperpolarizing factor
39. Analysis of the presence and physiological relevance of subconducting states of connexin 43-derived gap junction channels in cultured human corporal vascular smooth muscle cells
40. Gap junctions in vascular tissues. Evaluating the role of intercellular communications in the modulation of vasomotor tone
41. Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery
42. + currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels
43. Potassium channel pharmacology
44. Molecular cloning and regulation of expression of two novel mouse cyp4f genes: Expression in peroxisome proliferator-activated receptor alpha- deficient mice upon lipopolysaccharide and clofibrate challenges
45. Arginosuccinate synthetase, arginosuccinate lyase and NOS in canine gastrointestinal tract: Immunocytochemical studies
46. 2+-induced rat aortic relaxation in the absence of endothelium
47. The role of the membrane potential of endothelial and smooth muscle cells in the regulation of coronary blood flow
48. Glycyrrhetinic acid derivatives: A novel class of inhibitiors of gap-junctional intercellular communication. Structure-Activity relationships
49. Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid
50. + exchanges and the direct inhibitory effects of acetylcholine on canine femoral arteries
51. + channel
52. ·), the only nitrogen monoxide redox form capable of activating soluble guanylate cyclase
53. Pharmacological characterization of potassium channels in intact mesenteric arteries and single smooth muscle cells from eNOS -/- and +/+ mice
54. Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase
55. The other endothelium-derived relaxing factor: A review of recent findings concerning the nature and cellular actions of endothelium-derived hyperpolarizing factor (EDHF)
56. 2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery
57. Roles of calcium-activated and voltage-gated delayed rectifier potassium channels in endothelium-dependent vasorelaxation of the rabbit middle cerebral artery
58. Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels
59. Role of heterocellular gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: Inhibition by a connexin-mimetic peptide
60. Endothelial cell protein kinase G inhibits release of EDHF through a PKG-sensitive cation channel
61. Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium
62. Potassium does not mimic EDHF in rat mesenteric arteries
63. +
64. Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits
65. Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: Role of epoxyeicosatrienoic acid
66. Inward rectificaiton in sub-mucosal arterioles of guinea-pig ileum
67. Inward rectification in rat cerebral arterioles: Involvement of potassium ions in autoregulation
68. Endothelium-derived hyperpolarizing factor - A critical appraisal
69. EDHF - Are there gaps in the pathway?
70. Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein
71. + is an endothelium-derived hyperpolarizing factor in rat arteries
72. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries
73. Further investigation of endothelium-derived hyperpolarizing factor (EDHF) in rat hepatic artery: Studies using 1-EBIO and ouabain
74. Role of gap junctions and EETS in endothelium-dependent hyperpolarization of porcine coronary artery
75. Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta
76. Endothelial cell pathway for conduction of hyperpolarization and vasodilation along hamster feed artery
77. Electrical coupling between endothelial cells and smooth muscle cells in hamster feed arteries: Role in vasomotor control
78. Electrical activation of endothelium evokes vasodilation and hyperpolarization along hamster feed arteries
79. Functional implications of a newly characterized pathway of 11,12- epoxyeicosatrienoic acid metabolism in arterial smooth muscle
80. Expression of cytochrome P450s and microsomal epoxide hydrolase in primary cultures of human umbilical vein endothelial cells
81. The soluble guanylyl cyclase inhibitor 1H-( 1,2,4)oxadiazolo-(4,3-a)quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and cytochrome P-450 enzymes involved in nitric oxide donor bioactivation
82. Endothelium-dependent hyperpolarization of canine coronary smooth muscle
83. The alternative: EDHF
84. Cytochrome P450 2C is an EDHF synthase in coronary arteries
85. Myoendothelial gap junctions. The gap is there, but does EDHF go through it?
86. + pump in smooth muscle. Physiologic and pharmacologic significance
87. Evidence against a role of cytochrome P450-derived arachidonic acid metabolites in endothelium-dependent hyperpolarization by acetylcholine in rat isolated mesenteric artery
88. Ca channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid
89. Cytochrome P450-dependent effects of bradykinin in the rat heart
90. Pharmacological evaluation of an epoxide as the putative hyperpolarizing factor mediating the nitric oxide-independent vasodilator effect of bradykinin in the rat heart
91. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
92. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
93. Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery
94. Endothelium-dependent hyperpolarization: A role in the control of vascular tone
95. Rat coronary endothelial cell membrane potential responses during hypertension
96. G)-nitro-L-arginine and indomethacin in coronary circulation
97. 2+ current
98. Production of 20-HETE and its role in autoregulation of cerebral blood flow
99. Connexin-aequorin chimerae report cytoplasmic calcium environment along trafficking pathway leading to gap junction biosynthesis in living COS-7 cells
100. 2+ entry in human and bovine endothelial cells
101. Pharmacological characterization of five cloned voltage-gated K-channels, types Kv 1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines
102. +-ATPase activity by nitric oxide: A cGMP-independent effect
103. The mechanism of potassium vasodilation
104. +-ATPase
105. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels
106. Transduction of physical force by the vascular wall. Role of phospholipase C and cytochrome P450 metabolites of arachidonic acid
107. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone
108. Characterization of cannabinoid receptors coupled to vasorelaxation by endothelium-derived hyperpolarizing factor
109. + channels which contribute to the acetylcholine-induced hyperpolarization in smooth muscle of the guinea-pig submucosal arteriole
110. + channels
111. Endothelium-derived hyperpolarizing factor - Fact or fiction?
112. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals
113. The influence of nitric oxide synthesis on contractile and relaxant properties of rat carotid and mesenteric arteries
114. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type ii diabetes mellitus
115. Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3
116. Sodium pump hyperpolarization relaxation in rat caudal artery
117. 2+ entry in porcine aortic endothelial cells
118. Origin and function of epoxyeicosatrienoic acids in vascular endothelial cells: More than just endothelium-derived hyperpolarizing factor?
119. + channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid
120. 2
121. Determinants of apamin and d-tubocurarine block in SK potassium channels
122. A human intermediate conductance calcium-activated potassium channel
123. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles
124. 2 - Receptor-cAMP system in human aortic endothelial cells
125. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 and CB2 receptors
126. Inhibition of nitric oxide-induced vasodilation by gap junction inhibitors: A potential role for a cGMP-independent nitric oxide pathway
127. Nitric oxide synthesis by tracheal smooth muscle cells by a nitric oxide synthase-independent pathway
128. + release in isolated renal arteries of rats
129. Mechanisms of nitric oxide-independent relaxations induced by carbachol and acetyl-choline in rat isolated renal arteries
130. Possible existence of novel endothelium-derived relaxing factors in the endothelium of rat mesenteric arterial bed
131. Cytochrome P450 activity and endothelial dysfunction in insulin resistance
132. Glomerular stereospecific synthesis and hemodynamic actions of 8,9- epoxyeicosatrienoic acid in rat kidney
133. Inhibitors of cytochrome P-450 attenuate the myogenic response to dog renal arcuate arteries
134. Evidence that mechanisms dependent and independent of nitric oxide mediate endothelium-dependent relaxation to bradykinin in human small resistance-like coronary arteries
135. 2B receptors
136. Cytochrome P450 catalyzed nitric oxide synthesis: A theoretical study
137. Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term
138. +-induced hyperpolarization and dilations of rat coronary cerebral arteries involve inward rectifier channels
139. Endothelium-derived hyperpolarizing factor
140. Defective vascular development in connexin 45-deficient mice
141. The role of myoendothelial cell contact in non-nitric oxide, non-prostanoid-mediated endothelium-dependent relaxation of porcine coronary artery
142. The gap junction communication channel
143. Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity
144. Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide
145. Evidence against potassium as an endothelium-derived hyperpolarizing factor in rat mesenteric small arteries
146. Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms
147. Nitric oxide attenuates signal transduction - Possible role in dissociating caveolin-1 scaffold
148. Human umbilical vein endothelial cells express P450 2C8 mRNA: Cloning of endothelial P450 epoxygenase
149. Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vitro
150. Dye tracers define differential endothelial and smooth muscle coupling patterns within the arteriolar wall
151. Difference in endothelium-derived hyperpolarizing factor-mediated hyperpolarization and nitric oxide release between human internal mammary artery and saphenous vein
152. Potassium channel block by cytoplasmic polamines as the mechanism of intrinsic rectification
153. Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery
154. Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential
155. The pathogenesis of cardiovascular disease: Role of the endothelium as a target and mediator
156. P2U-receptor mediated endothelium-dependent but nitric oxide-independent vascular relaxation
157. Calcium-activated potassium currents in the endothelium of the intact rat aorta
158. Citrulline does not relax isolated rat and rabbit vessels
159. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice
160. Microsomal cytochrome P450 1A1 dependent monooxygenase activity in guinea-pig heart: Induction, inhibition and increased activity by addition of exogenous NADPH-cytochrome P450 reductase
161. Potassium dilates rat cerebral arteries by two independent mechanisms
162. Missing links: Cytochrome P450 arachidonate products. A new class of lipid mediators
163. Expression of the cytochromes P450-NADPH-cytochrome P450 reductase system during in vivo tolerance and identification of CYPs in human peripheral arteries
164. Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydribiopterin deficiency
165. Nitric oxide synthase-independent release of nitric oxide induced by KCl in the perfused mesenteric bed of the rat
166. Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels
167. Ca) in smooth muscle cells isolated from the rat mesentery artery
168. + channels
169. + channels
170. Arachidonic acid blocks gap junctions between retinal horizontal cells
171. Endothelium-derived hyperpolarizing factor(s): Updating the unknown
172. Bioassay of endothelium-derived hyperpolarizing factor
173. 2+ in endothelial cells
174. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels
175. Endothelium-derived hyperpolarizing factor and endothelium-dependent relaxations
176. Specific localization of gap junction protein, connexin45, in the deep muscular plexus of dog and rat small intestine
177. Physiological roles and properties of potassium channels in arterial smooth muscle
178. Potassium channels activated in the endothelium-dependent hyperpolarization in guinea-pig coronary artery
179. Determination of 14,15-epoxyeicosatrienoic acid and 14,15- dihydroxyeicosatrienoic acid by fluoroimmunoassay
180. Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns
181. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation
182. Stretch revealed three components in the hyperpolarization of guinea-pig coronary artery in response to acetylcholine
183. Role of membrane potential in endothelium-dependent relaxation of guinea-pig coronary arterial smooth muscle
184. Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries
185. Characterization of endothelium-dependent relaxation in guinea-pig basilar artery - Effect of hypoxia and role of cytochrome P450 mono-oxygenase
186. Identification of the 11,14,15- and 11,12,15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta
187. Identification of 11,12,15-trihydroxyeicosatrienoic acid as the mediator of acetylcholine- and arachidonic acid-induced relaxation in rabbit aorta
188. Multiple pathways underlying endothelium-dependent relaxation in the rabbit isolated femoral artery
189. Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries
190. A transferable β-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells
191. Metabolism of arachidonic acid to 20-hydroxy-5,8,11,14-eicosatetraenoic acid by P450 enzymes in human liver: Involvement of CYP4F2 and CYP4A11
192. 20-HETE relaxes bovine coronary arteries through the release of prostacyclin
193. N-arachidonylethanolamine relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor
194. Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs
195. K+-induced dilation of a small renal artery: No role for inward rectifier K+ channels
196. Inward rectifier K+ currents in smooth muscle cells from rat resistance sized cerebral arteries
197. The properties and distribution of inward rectifier potassium currents in pig coronary smooth muscle
198. Potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig carotid and porcine coronary arteries
199. + channels in smooth muscle cells of the rabbit and guinea-pig carotid arteries
200. Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery
201. Is EDHF an epoxyeicosatrienoic acid?
202. Hyperpolarizing factors
203. Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF
204. Anandamide and endothelium-derived hyperpolarizing factor act via a common vasorelaxant mechanism in rat mesentery
205. An endogenous cannabinoid as an endothelium-derived vasorelaxant
206. Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue
207. cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery
208. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension
209. Renal and cardiovascular actions of 20- hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids
210. Relaxant effects of L-citrulline in rabbit vascular smooth muscle
211. L-citrulline, the by-product of nitric oxide synthesis, decreases vascular smooth muscle cell proliferation
212. Effect of 18β-glycyrrhetinic acid on electrochemical coupling in the guinea-pig renal pelvis and ureter
213. Incidence of myoendothelial gap junctions in the proximal and distal mersenteric arteries of the rat is suggestive of a role in endothelium-derived hyperpolarizing factor-mediated responses
214. Exogenous NG-hydroxyl-L-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity
215. Characterization of 1H (1,2,4)-oxadiazolo(4,3-a)quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase
216. Flow control among microvessels co-ordinated by intercellular conduction
217. Cytochrome P450 monooxygenase system: Localization in smooth muscle of rabbit aorta
218. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation
219. In vitro simultaneous measurements of relaxation and nitric oxide concentrations in rat superior mesenteric artery
220. Effects of cytochrome P-450 inhibitors on endothelium-dependent relaxation in rabbit aorta
221. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
222. Regulation of shear stress in the canine coronary microcirculation
223. Origin of superoxide production by endothelial nitric oxide synthase
224. Cytochrome P-450 arachidonate metabolites in rat kidney: Characterization and hemodynamic responses
225. Important role of endothelium-derived hyperpolarizing factor in shear stress - Induced endothelium-dependent relaxations in the rat mesenteric artery
226. EDHF, NO and a prostanoid: Hyperpolarization-dependent and -independent relaxation in guinea-pig arteries
227. Inhibition of the gap junctional component of endothelium-dependent relaxations in rabbit iliac artery by 18-βglycyrrhetinic acid
228. 2+ channels in lung microvascular cells
229. Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: Implications for endothelial dysfunction and vascular biology
230. Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: Importance of processes mediating precontractions
231. Coronary nitric oxide production in response to excercise and endothelium-dependent agonists
232. + channels, membrane potential and the release of vasoactive factors from the vascular endothelium
233. Endothelium-derived hyperpolarizing factor(s): Species and tissue heterogenity
234. Importance of endothelium-derived hyperpolarizingfFactor in human arteries
235. Influence of cytochrome P-450 inhibitors on endothelium-dependent nitric-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries
236. 2+ and relation to potassium ions
237. Evidence against the involvement of cytochrome P450 metabolites in endothelium-dependent hyperpolarization of the rat main mesenteric artery
238. Barium decreases endothelium-dependent smooth muscle responses to transient but not more prolonged acetylcholine applications
239. EDHF and residual NO: Different factors
240. + currents
241. Old timer makes a comeback
242. Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals
243. Defective endothelium-dependent relaxation in fructose-hypertensive rats
244. Tetrahydrobiopterin improves endothelial function in human saphenous veins
245. Effect of potassium channel blockers on L-NAME insensitive relaxations in rat small mesenteric artery
246. Endothelium-dependent hyperpolarization of vascular smooth muscle: Role for a non-nitric oxide synthase product
247. Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase
248. + current of vascular myoctes by clotrimazole but not involving inhibition of cytochrome P450
249. Monovalent ion selectivity sequences of the rat connexin 43 gap junction channel
250. Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: Arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein
251. Endothelium-dependent relaxation by substance P in human isolated omental arteries and veins: Relative contribution of prostanoids, nitric oxide and hyperpolarization
252. A case for myoendothelial gap junctions
253. Role of EDHF in conduction of vasodilation along hamster cheek pouch arterioles in vivo
254. A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery
255. The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery
256. Cytochrome P-450 pathway in acetyl-choline-induced canine coronary microvascular vasodilation in vivo
257. Different responses to acetylcholine in the presence of nitric oxide inhibitor in rat aortae and mesenteric arteries
258. Loss of acetylcholine-induced relaxation by M3-receptor activation in mesenteric arteries of spontaneously hypertensive rats
259. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
260. Endothelium-dependent hyperpolarization and intercellular electrical coupling in guinea-pig mesenteric arterioles
261. Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney
262. +-mediated vasodilation
263. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: Characterization and significance
264. CYP2J subfamily P450s in the lung: Expression, localization, and potential functional significance
265. CYP2J subfamily cytochrome P450s in the gastrointestinal tract: Expression, localization, and potential functional significance
266. Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs
267. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries
268. Effects of 17-ODYA, a suicide-substrate inhibitor of P450 fatty acid ω-hydroxylase on renal function of rats
269. Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K1 channel activity
270. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery
271. Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery
272. Studies on the effects of anandamide in rat hepatic artery
273. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
274. Differential actions of anandamide, potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig basilar artery