The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery

British Journal of Pharmacology

Volumn 125, Issue 3, 1998, Pages 533-541

  White, Richard ^a   Hiley, C Robin ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Anandamide; Caffeine; Cannabinoid antagonists; Cannabinoids; Palmitoylethanolamide; Rat small mesenteric artery; SR 141716A

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; CAFFEINE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; DEXANABINOL; METHOXAMINE; POTASSIUM CHLORIDE; RIMONABANT;

ANIMAL TISSUE; ARTERY DILATATION; ARTERY TONE; ARTICLE; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; EXTRACELLULAR CALCIUM; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; ARACHIDONIC ACIDS; CANNABINOIDS; CYCLOHEXANOLS; ENDOTHELIUM, VASCULAR; LIGANDS; MALE; MESENTERIC ARTERIES; METHOXAMINE; MORPHOLINES; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NAPHTHALENES; PALMITIC ACIDS; POLYUNSATURATED ALKAMIDES; RATS; RATS, WISTAR; TETRAHYDROCANNABINOL;

EID: 0031714873     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702111     Document Type: Article

References (35)

1. ABADJI, V., LIN, S.Y., TAHA, G., GRIFFIN, G., STEVENSON, L.A., PERTWEE, R.G. & MAKRIYANNIS, A. (1994). (R)-methanandamide - a chiral novel anandamide possessing higher potency and metabolic stability. J. Med. Chem., 37, 1889-1893.
2. 2+ concentration produced by noradrenaline in rat mesenteric artery smooth muscle cells. J. Physiol., 482, 247-258.
3. 2+ current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism. Br. J. Pharmacol., 106, 231-232.
4. 2+ channel antagonists and inhibition of protein kinase C each block contraction but not depolarization to 5-hydroxytryptamine in the rabbit basilar artery. Eur. J. Pharmacol., 235, 113-116.
5. CRIDDLE, D.N., DEMOURA, R.S., GREENWOOD, I.A. & LARGE, W.A. (1996). Effect of niflumic acid on noradrenaline-induced contractions of the rat aorta. Br. J. Pharmacol., 118, 1065-1071.
6. DEUTSCH, D.G., GOLIGORSKY, M.S., SCHMID, P.C., KREBSBACH, R.J., SCHMID, H.H.O., DAS, S.K., DEY, S.K., ARREAZA, G., THORUP, C., STEFANO, G. & MOORE, L.C. (1997). Production and physiological actions of anandamide in the vasculature of the rat kidney. J. Clin. Invest., 100, 1538-1546.
7. DI MARZO, V., FONTANA, A., CADAS, H., SCHINELLI, S., CIMINO, G., SCHWARTZ, J.-C. & PIOMELLI, D. (1994). Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature, 372, 686-691.
8. FACCI, L., DALTOSO, R., ROMANELLO, S., BURIANI, A., SKAPER, S.D. & LEON, A. (1995). Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc. Natl. Acad. Sci. USA., 92, 3376-3380.
9. 2 receptors. Mol. Pharmacol., 48, 443-450.
10. i increases partly sensitive to capacitative store refilling. Eur. J. Pharmacol., 336, R1-R3.
11. 2+ influx by unsaturated fatty acids. Cell Calcium, 21, 375-385.
12. GARCHA, R.S. & HUGHES, A.D. (1995). Inhibition of norepinephrine and caffeine-induced activation by ryanodine and thapsigargin in rat mesenteric arteries. J. Cardiovasc. Pharmacol., 25, 840-846.
13. HOWLETT, A.C. (1995). Pharmacology of cannabinoid receptors. Ann. Rev. Pharmacol. Toxicol., 35, 607-634.
14. JULOU-SCHAEFFER, G. & FRESLON, J.L. (1988). Effects of ryanodine on tension development in rat aorta and mesenteric resistance vessels. Br. J. Pharmacol., 95, 605-613.
15. KARAKI, H., OZAKI, H., HORI, M., MITSUISAITO, M., AMANO, K.I., HARADA, K.I., MIYAMOTO, S., NAKAZAWA, H., WON, K.J. & SATO, K. (1997). Calcium movements, distribution, and functions in smooth muscle. Pharmacol. Rev., 49, 157-230.
16. KIRKUP, A.J., EDWARDS, G., GREEN, M.E., MILLER, M., WALKER, S.D. & WESTON, A.H. (1996). Modulation of membrane currents and mechanical activity by niflumic acid in rat vascular smooth muscle. Eur. J. Pharmacol., 317, 165-174.
17. 1-like cannabinoid receptors. J. Pharmacol. Exp. Ther., 281, 1030-1037.
18. MATSUDA, L.A., LOLAIT, S.J., BROWNSTEIN, M.J., YOUNG, A.C. & BONNER, T.I. (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346, 561-564.
19. MULVANY, M.J. & HALPERN, W. (1977). Contractile responses of small resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res., 41, 19-26.
20. MUNRO, S., THOMAS, K.L. & ABU-SHAAR, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 61-65.
21. PLANE, F., HOLLAND, M., WALDRON, G.J., GARLAND, C.J. & BOYLE, J.P. (1997). Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. Br. J. Pharmacol., 121, 1509-1511.
22. 1 cannabinoid receptor. Am. J. Physiol., 43, H375-H381.
23. RANDALL, M.D., ALEXANDER, S.P.H., BENNETT, T., BOYD, E.A., FRY, J.R., GARDINER, S.M., KEMP, P.A., McCULLOCH, A.I. & KENDALL, D.A. (1996). An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem. Biophys. Res. Commun., 229, 114-120.
24. RANDALL, M.D. & KENDALL, D.A. (1998). Endocannabinoids: a new class of vasoactive substances. Trends Pharmacol. Sci., 19, 55-58.
25. RINALDI-CARMONA, M., BARTH, F., HEAULEME, M., SHIRE, D., CALANDRA, B., CONGY, C., MARTINEZ, S. MARUANI, J., NELIAT, G., CAPUT, D., FERRARA, P., SOUBRIE, P., BRELIERE, J.C. & LE FUR, G. (1994). SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett., 350, 240-244.
26. 1 cannabinoid receptor isoforms. J. Pharm. Exp. Ther., 278, 871-878.
27. SHIRE, D., CARILLON, C., KAGHAD, M., CALANDRA, B., RINALDI-CARMONA, M., LE FUR, G., CAPUT, D. & FERRARA, P. (1995). An amino terminal variant of the central cannabinoid receptor resulting from alternative splicing. J. Biol. Chem., 270, 3726-3731.
28. 2): identification of cannabinoid receptor subtype selective ligands. J. Pharm. Exp. Ther., 278, 989-999.
29. VENANCE, L., SAGAN, S. & GIAUME, C. (1997). (R)-methanandamide inhibits receptor-induced calcium responses by depleting internal calcium stores in cultured astrocytes. Pflugers Archiv., 434, 147-149.
30. VIDRIO, H., SANCHEZ-SALVATORI, M.A. & MEDINA, M. (1996). Cardiovascular effects of (-)-11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl in rats. J. Cardiovasc. Pharmacol., 28, 332-336.
31. 1 cannabinoid receptors in haemorrhagic shock. Nature, 390, 518-521.
32. WHITE, R. & HILEY, C.R. (1997). A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. Br. J. Pharmacol., 122, 1573-1584.
33. WHITE, R. & HILEY, C.R. (1998a). Studies on the effects of cannabinoid receptor ligands in the small mesenteric artery of the rat. Br. J. Pharmacol., 123, 65P.
34. WHITE, R. & HILEY, C.R. (1998b). The actions of the cannabinoid receptor antagonist, SR 141716a, in the rat isolated mesenteric artery. Br. J. Pharmacol., In press.
35. ZYGMUNT, P.M., HÖGESTÄTT, E.D., WALDECK, K., EDWARDS, G., KIRKUP, A.J. & WESTON, A.H. (1997). Studies on the effects of anandamide in rat hepatic artery. Br. J. Pharmacol., 122, 1679-1686.