Evidence against a role of cytochrome P450-derived arachidonic acid metabolites in endothelium-dependent hyperpolarization by acetylcholine in rat isolated mesenteric artery

British Journal of Pharmacology

Volumn 120, Issue 3, 1997, Pages 439-446

  Fukao, Mitsuhiro ^a   Hattori, Yuichi ^a   Kanno, Morio ^a   Sakuma, Ichiro ^a   Kitabatake, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Arachidonic acid; Cytochrome P450; Endothelium derived hyperpolarizing factor; Epoxyeicosatrienoic acid; Hyperpolarization; Rat mesenteric artery

Indexed keywords

ACETYLCHOLINE; ALPHA NAPHTHOFLAVONE; ANTIFUNGAL AGENT; ARACHIDONIC ACID DERIVATIVE; CLOTRIMAZOLE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLIBENCLAMIDE; KETOCONAZOLE; LIPOPOLYSACCHARIDE; MEPACRINE; METYRAPONE; MICONAZOLE; NITROPRUSSIDE SODIUM; PENTOBARBITAL; PHOSPHOLIPASE INHIBITOR; PINACIDIL; PROADIFEN; TROLEANDOMYCIN;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; HYPERPOLARIZATION; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL;

ACETYLCHOLINE; ANIMALS; ANTIFUNGAL AGENTS; ARACHIDONIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIUM, VASCULAR; GUANIDINES; IMIDAZOLES; LIPOPOLYSACCHARIDES; MALE; MESENTERIC ARTERIES; MUSCLE, SMOOTH, VASCULAR; PHOSPHOLIPASES A; PINACIDIL; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0031017779     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700932     Document Type: Article

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