Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery

British Journal of Pharmacology

Volumn 121, Issue 1, 1997, Pages 141-149

  Zygmunt, Peter M ^a   Edwards, Gillian ^a   Weston, Arthur H ^a   Larsson, Bengt ^b   Högestätt, Edward D ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apamin; Charybdotoxin; Ciclazindol; Dofetilide; Hyperpolarization; Potassium channels; Radioligand binding; Relaxation; Terikalant; Vascular endothelium; Whole cell patch clamp

Indexed keywords

ACETYLCHOLINE; AGITOXIN 2; APAMIN; CHARYBDOTOXIN; CICLAZINDOL; DENDROTOXIN; DOFETILIDE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; KALIOTOXIN; MARGATOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TERIKALANT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BRAIN CORTEX; FEMALE; HEPATIC ARTERY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

EID: 0030899401     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701108     Document Type: Article

References (47)

1. +]: a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed. J. Cardiovasc. Pharmacol., 21, 423 - 429.
2. BOLTON, T.B. & BEECH, D.J. (1992). Smooth muscle potassium channels, their electrophysiology and function. In Potassium Channel Modulators. ed. Weston, A.H. & Hamilton, T.C. pp. 144 - 180. Oxford: Blackwell Scientific.
3. BUSSE, R., MÜLSCH, A., FLEMING, I. & HECKER, M. (1993). Mechanisms of nitric oxide release from the vascular endothelium. Circulation, 87, (Suppl. V) V-18 - V-25.
4. CHANDY, K.G. & GUTMAN, G.A. (1995). Voltage-gated potassium channel genes. In Ligand- and Voltage-Gated Ion Channels. ed. North, R.A. pp. 2 - 71. Boca Raton: CRC Press.
5. CHEN, G., SUZUKI, H. & WESTON, A.H. (1988). Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br. J. Pharmacol. 95, 1165 - 1174.
6. COWAN, C.L., PALACINO, J.J., NAJIBI, S. & COHEN, R.A. (1993). Potassium-channel-mediated relaxation to acetylcholine in rabbit arteries. J. Pharmacol. Exp. Ther., 266, 1482 - 1489.
7. CORRIU, C., FELETOU, M., CANET, E. & VANHOUTTE, P.M. (1996). Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. Br. J. Pharmacol., 119, 959 - 964.
8. + channels characterized from Androctonus mauretanicus mauretanicus venom. J. Biol. Chem., 267, 1640 - 1647.
9. Ca channel opener, in rat portal vein. Br. J. Pharmacol., 113, 1538 - 1547.
10. EDWARDS, G. & WESTON, A.H. (1997). Effect of potassium channel modulating drugs on isolated smooth muscle. In Molecular Biology of the Neuron. ed. Davies, R.W. & Morris, B. pp. 145 - 175. Oxford: βios Scientific (in press).
11. FÉLÉTOU, M. & VANHOUTTE, P.M. (1988). Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br. J. Pharmacol., 93, 515 - 524.
12. + channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry, 33, 6834 - 6839.
13. GARCIA, M.L., KNAUS, H.-G., MUNUJOS, P., SLAUGHTER, R.S. & KACZOROWSKI, G.J. (1995). Charybdotoxin and its effects on potassium channels. Am. J. Physiol., 269, C1 - C10.
14. + conductance. Br. J. Pharmacol., 115, 1221 - 1230.
15. GARLAND, C.J., PLANE, F., KEMP, B.K. & COCKS, T.M. (1995). Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol. Sci., 16, 23 - 30.
16. GIANGIACOMO, K.M., GARCIA, M.L. & MCMANUS, O.B. (1992). Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle. Biochemistry, 31, 6719 - 6727.
17. GREEN, M.E., EDWARDS, G., KIRKUP, A.J., MILLER, M. & WESTON, A.H. (1996). Pharmacological characterization of the inwardly-rectifying current in the smooth muscle cells of the rat bladder. Br. J. Pharmacol., 119, 1509 - 1518.
18. GWILT, M., ARROWSMITH, J.E., BLACKBURN, K.J., BURGES, R.A., CROSS, P.E., DALRYMPLE, H.W. & HIGGINS, A.J. (1991). UK-68,798: A novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J. Pharmacol. Exp. Ther., 256, 318 - 324.
19. 3 receptor stimulation in guinea-pig coronary artery. Br. J. Pharmacol., 115, 717 - 722.
20. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv., 391, 85 - 100.
21. HECKER, M., BARA, A.T., BAUERSACHS, J. & BUSSE, R. (1994). Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol., 481, 407 - 414.
22. i of endothelial cells in situ and relaxes porcine coronary artery. Am. J. Physiol., 270, H2038 - H2049.
23. HORN, R. & MARTY, A. (1988). Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol., 92, 145 - 159.
24. HÖGESTÄTT, E.D., ANDERSSON, K.-E. & EDVINSSON, L. (1983). Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol. Scand., 117, 49 - 61.
25. KACZOROWSKI, G.J., KNAUS, H.G., LEONARD, R.J., McMANUS, O.B. & GARCIA, M.L. (1996). High-conductance calciumactivated potassium channels; structure, pharmacology, and function. J. Bioenerg. Biomembr. 28, 255 - 267.
26. KLÖCKNER, U. & ISENBERG, G. (1985). Action potential and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea-pig). Pflügers Archiv., 405, 329 - 339.
27. KÖHLER, M., HIRSCHBERG, B., BOND, C.T., KINZIE, J.M., MARRION, N.V., MAYLIE, J. & ADELMAN, J.P. (1996). Small-conductance, calcium-activated potassium channels from mammalian brain. Science, 273, 1709 - 1714.
28. LISCHKE, V., BUSSE, R. & HECKER, M. (1995). Selective inhibition by barbiturates of the synthesis of endothelium-derived hyperpolarizing factor in the rabbit carotid artery. Br. J. Pharmacol., 115, 969 - 974.
29. + channel blocking peptides. Neuron, 15, 5 - 10.
30. + channels mediated an endothelium-dependent hyperpolarization in rabbit mesenteric arteries. J. Physiol., 489, 723 - 734.
31. NAGAO, T. & VANHOUTTE, P.M. (1993). Endothelium-derived hyperpolarizing factor and endothelium-dependent relaxations. Am. J. Respir. Cell Mol. Biol., 8, 1 - 6.
32. NOACK, Th., EDWARDS, G., DEITMER, P., GREENGRASS, P., MORITA, T., ANDERSSON, P.-O., CRIDDLE, D., WYLLIE, M.G. & WESTON, A.H. (1992). The involvement of potassium channels in the action of ciclazindol in rat portal vein. Br. J. Pharmacol., 106, 17 - 24.
33. PARSONS, S.J.W., SUMNER, M. & GARLAND, C.J. (1996). Apaminsensitive responses to acetylcholine in rabbit isolated mesenteric arteries. Br. J. Pharmacol. Proc. Suppl., 117, 278p.
34. PETERSSON, J., ZYGMUNT, P.M., BRANDT, L. & HÖGESTÄTT, E.D. (1995). Substance P-induced relaxation and hyperpolarization in human cerebral arteries. Br. J. Pharmacol., 115, 889 - 894.
35. PETERSSON, J., ZYGMUNT, P.M. & HÖGESTÄTT, E.D. (1996). Charybdotoxin and apamin inhibit relaxations mediated by EDHF in the guinea-pig basilar artery. Br. J. Pharmacol. Proc. Suppl. 117, 119P.
36. RAE, J., COOPER, K., GATES, P. & WATSKY, M. (1991). Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Methods, 37, 15 - 26.
37. SOKOL, P.T., HU, W., YI, L., TORAL, J., CHANDRA, M. & ZIAI, M.R. (1994). Cloning of an apamin binding protein of vascular smooth muscle. J. Protein Chemistry, 13, 117 - 128.
38. TAYLOR, S.G. & WESTON, A H (1988). Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from the vascular endothelium. Trends Pharmacol. Sci., 9, 272 - 274.
39. VAZQUEZ, J., FEIGENBAUM, P., KING, V.F., KACZOROWSKI, G.J. & GARCIA, M.L. (1990). Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain, J. Biol. Chem., 265, 15564 - 15571.
40. + channel in aortic smooth muscle cells (A7r5 line and primary cultures). Pflügers Arch., 420, 417 - 423.
41. WALDRON, G.J. & GARLAND, C.J. (1994). Effect of potassium channel blockers on L-NAME insensitive relaxations in rat small mesenteric artery. Can. J. Physiol. Pharmacol., 72 (S1), 115.
42. WALKER, S., EDWARDS, G., GREEN, M.E. & WESTON, A.H. (1996). Characterisation of potassium currents in rat pulmonary arterial smooth muscle cells. Br. J. Pharmacol. Proc. Suppl., 119, 80P.
43. ZYGMUNT, P.M. (1995). Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle. PhD Thesis, Lund University.
44. ω-nitro-L-arginine in the rat hepatic artery and aorta. Acta Physiol. Scand., 152, 107 - 114.
45. ZYGMUNT, P.M & HÖGESTÄTT, E.D. (1996). Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br. J. Pharmacol., 117, 1600 - 1606.
46. ZYGMUNT, P.M., PETERSSON, J., WESTON, A.M. & HÖGESTÄTT, E.D. (1996). Effects of ciclazindol on EDHF-mediated relaxations in the rat hepatic and guinea-pig basilar arteries. Br. J. Pharmacol. Proc. Suppl., 119, 76P.
47. ZYGMUNT, P.M., WALDECK, K. & HÖGESTÄTT, E.D. (1994b). The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery. Acta Physiol. Scand., 152, 375 - 384.