Regulation of vascular tone by endothelium-derived hyperpolarizing factor

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 2, 1999, Pages 172-175

  Cheung, D W ^a   Chen, G ^a   MacKay, M J ^a   Burnette, E ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

Endothelium derived hyperpolarizing factor; Membrane potential; Mesenteric artery; Nitric oxide; Pinacidil

Indexed keywords

BIOLOGICAL FACTOR; ENDOTHELIUM DEPENDENT HYPERPOLARIZATION FACTOR; ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION FACTOR; NITRIC OXIDE; PINACIDIL; VASODILATOR AGENT;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; MALE; MESENTERIC ARTERY; PHYSIOLOGY; RAT; VASOCONSTRICTION; VASODILATATION; WISTAR KYOTO RAT;

ANIMALS; BIOLOGICAL FACTORS; MALE; MEMBRANE POTENTIALS; MESENTERIC ARTERIES; NITRIC OXIDE; PINACIDIL; RATS; RATS, INBRED WKY; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS;

EID: 0033069277     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03008.x     Document Type: Conference Paper

References (6)

1. Chen O, Suzuki H, Weston A. Acetylcholine releases endothelium-derived hyperpolarization factor and EDRF from rat blood vessels. Br. J. Pharmacol. 1988; 95: 1165-74.
2. Heeker M, Bara A, Bauersachs J, Busse R. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol. 1994; 481: 407-14.
3. Campbell W, Gebremedhin D, Pratt P, Harder D. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 1996; 78: 415-23.
4. Chen G, Cheung DW. Hyperpolarization and relaxation induced by acetylcholine and NO in the rat mesenteric arteries. In: Vanhoulte P (ed.). Endothelium-derived Hyperpolarizing Factor. Harwood Publishers, Amsterdam. 1996; Ch. 13.
5. Chen G, Cheung DW. Modulation of endothelium-dependent hyperpolarization and relaxation to acetylcholine in rat mesenteric artery by cytochrome P450 enzyme activity. Circ. Res. 1996; 79: 827-33.
6. +-thannel blockers on ACh-induced hyperpolarization and relaxation in mesenteric arteries. Am. J. Physiol. 1997; 272: H2306-12.