Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+-dependent K+ channel

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 271, Issue 5 15-5, 1996, Pages

  Devor, Daniel C ^a   Singh, Ashvani K ^a   Frizzell, Raymond A ^a   Bridges, Robert J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

1 ethyl 2 benzimidazolinone; chloride secretion; potassium channels

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; BENZIMIDAZOLE DERIVATIVE; CALCIUM ION; CHARYBDOTOXIN; FORSKOLIN; NYSTATIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; RUBIDIUM 86; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CHLORIDE TRANSPORT; COLON MUCOSA; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT CIRCUIT CURRENT; TRACHEA MUCOSA;

EID: 0029958489     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.271.5.l775     Document Type: Article

References (41)

1. Anderson, M. P., and M. J. Welsh. Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia. Proc. Natl. Acad. Sci. USA 88: 6003-6007, 1991.
2. Andres, H., R. Bock, R. J. Bridges, W. Rummel, and J. Schreiner. Submucosal plexus and electrolyte transport across rat colonic mucosa. J. Physiol. Lond. 364: 301-312, 1985.
3. + currents by secretory stimulation in human epithelial cells. J. Physiol. Lond. 478: 469-482, 1994.
4. Barrett, K. E. Positive and negative regulation of chloride secretion in T84 cells. Am. J. Physiol. 265 (Cell Physiol. 34): C859-C868, 1993.
5. + uptake into colonic enterocyte membrane vesicles. Am. J. Physiol. 254 (Cell Physiol. 23): C484-C490, 1988.
6. Bridges, R. J., W. Rummel, and P. Wollenberg. Effects of vasopressin on electrolyte transport across isolated colon from normal and dexamethasone-treated rats. J Physiol. Lond. 355: 11-23, 1984.
7. Clarke, L. L., K. A. Burns, J.-Y. Bayle, R. C. Boucher, and M. R. Van Scott. Sodium- and chloride-conductive pathways in cultured mouse tracheal epithelium. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L519-L525, 1992.
8. --secreting epithelial cells. Proc. Natl. Acad. Sci. USA 87: 4956-4960, 1990.
9. Dawson, D. C., and N. W. Richards. Basolateral K conductance: role in regulation of NaCl absorption and secretion. Am. J. Physiol. 259 (Cell Physiol. 28): C181-C195, 1990.
10. -, and nonselective cation conductances in T84 cells: a perforated patch-clamp study. Am. J. Physiol. 263 (Cell Physiol. 32): C780-C787, 1992.
11. - channels in primary cultures of spiny dogfish (Squalus acanthias) rectal gland. Am. J. Physiol. 268 (Cell Physiol. 37): C70-C79, 1995.
12. - channel in colonic secretory cells. Am. J. Physiol. 265 (Cell Physiol. 34): C1271-C1280, 1993.
13. - channel in T84 colonic secretory cells (Abstract). FASEB J. 8: A295, 1994.
14. Devor, D. C., S. M. Simasko, and M. E. Duffey. Carbachol induces oscillations of membrane potassium conductance in a colonic cell line, T84. Am. J. Physiol. 258 (Cell Physiol. 27): C318-C326, 1990.
15. K. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L785-L795, 1996.
16. 84-Cells. Am. J. Physiol. 256 (Cell Physiol. 25): C1224-C1230, 1989.
17. Dharmsathaphorn, K., and S. J. Pandol. Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line. J. Clin. Invest. 77: 348-354, 1986.
18. Galvez, A., G. Gimenez-Gallego, J. P. Reuben, L. Roy-Contancin, P. Feigenbaum, G. J. Kaczorowski, and M. L. J. Garcia. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 265: 11083-11090, 1990.
19. Garty, H., B. Rudy, and S. J. D. Karlish. A simple and sensitive procedure for measuring isotope fluxes through ion-specific channels in heterogeneous populations of membrane vesicles. J. Biol. Chem. 258: 13094-13099, 1983.
20. Gasko, O. D., A. F. Knowles, H. G. Shertzor, E. M. Soulina, and E. Racker. The use of ion-exchange resins for studying ion transport in biological systems. Anal. Biochem. 72: 57-65, 1976.
21. Gribkoff, V. K., G. Champigny, P. Barbry, S. I. Dworetzky, N. A. Meanwell, and M. Lazdunski. The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel. J. Biol. Chem. 269: 10983-10986, 1994.
22. - secretion in nasal epithelia of CF mice. Am. J. Physiol. 266 (Cell Physiol. 35): C1478-C1483, 1994.
23. Kachintorn, U., M. Vajanaphanich, A. E. Traynor-Kaplan, K. Dharmsathaphorn, and K. E. Barrett. Activation by calcium alone of chloride secretion in T84 epithelial cells. Br. J. Pharmacol. 109: 510-517, 1993.
24. Knaus, H.-G., O. B. McManus, S. H. Lee, W. A. Schmalhofer, M. Garcia-Calvo, L. M. H. Helms, M. Sanchez, K. Giangiacomo, J. P. Reuben, A. B. Smith III, G. J. Kaczorowski, and M. L. Garcia. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33: 5819-5828, 1994.
25. Knowles, M., G. Murray, J. Shallal, F. Askin, V. Ranga, J. Gatzy, and R. Boucher. Bioelectric properties and ion flow across excised human bronchi. J. Appl. Physiol. 56: 868-877, 1984.
26. Knowles, M. R., L. L. Clarke, and R. C. Boucher. Activation by extracellular nucleotides of chloride secretion in the airway epithelium of patients with cystic fibrosis. N. Engl. J. Med. 325: 533-538, 1991.
27. + conductance. Pfluegers Arch. 429: 517-530, 1995.
28. McCann, J. D., R. C. Bhalla, and M. J. Welsh. Release of intracellular calcium by two different second messengers in airway epithelium. Am. J. Physiol. 257 (Lung Cell. Mol. Physiol. 1): L116-L124, 1989.
29. 2+ and block by charybdotoxin. Am. J. Physiol. 258 (Lung Cell. Mol. Physiol. 2): L334-L342, 1990.
30. McKay, M. C., S. I. Dworetzky, N. A. Meanwell, S.-P. Olesen, P. H. Reinhart, I. B. Levitan, J. P. Adelman, and V. K. Gribkoff. Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004. J. Neurophysiol. 71: 1873-1882, 1994.
31. + transport in a human colonic epithelial cell line. J. Biol. Chem. 260: 14163-14172, 1985.
32. + channels by novel benzimidazolone. Eur. J. Pharmacol. 251: 53-59, 1994.
33. 2+ and phosphorylation in normal (T84) and cystic fibrosis (CFPAC-1) epithelial cells. Pfluegers Arch. 426: 355-363, 1995.
34. Schultz, B. D., A. D. G. DeRoos, C. J. Venglarik, A. K. Singh, R. A. Frizzell, and R. J. Bridges. Glibenclamide blockade of CFTR chloride channels. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L192-L200, 1996.
35. Schultz, S. G. Homocellular regulatory mechanisms in sodium-transporting epithelia: avoidance of extinction by "flush-through." Am. J. Physiol. 241 (Renal Fluid Electrolyte Physiol. 10): F579-F590, 1981.
36. Ca channels in acutely dissociated neurons from the rat ventromedial hypothalamus by NS1619. Br. J. Pharmacol. 113: 659-661, 1994.
37. - channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents. J. Gen. Physiol. 100: 573-591, 1992.
38. Singh, A. K., C. J. Venglarik, and R. J. Bridges. Development of chloride channel modulators. Kidney Int. 48: 985-993, 1995.
39. Smith, P. L., and R. A. Frizzell. Chloride secretion by canine tracheal epithelum. IV. Basolateral membrane K permeability parallels secretion rate. J. Membr. Biol. 77: 187-199, 1984.
40. 84 epithelial cell line by calcium, nucleotides, and kinases. J. Membr. Biol. 142: 255-266, 1994.
41. K explore calcium's role. J. Gen. Physiol. 96: 1271-1285, 1990.