Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro- L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries

Journal of Cardiovascular Pharmacology

Volumn 29, Issue 6, 1997, Pages 827-832

  Van De Voorde, J ^a   Vanheel, B ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Cromakalim; Cytochrome P 450; EDHF; Endothelium; Miconazole; Proadifen

Indexed keywords

1 AMINOBENZOTRIAZOLE; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; CROMAKALIM; CYTOCHROME P450; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; MICONAZOLE; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; PROADIFEN; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; ENZYME INHIBITION; FEMALE; HEART MUSCLE TENSION; HYPERPOLARIZATION; MESENTERIC ARTERY; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; VASCULAR RESISTANCE;

ACETYLCHOLINE; ANIMALS; BENZOPYRANS; BIOLOGICAL FACTORS; CROMAKALIM; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS, UNSATURATED; FEMALE; MESENTERIC ARTERIES; MICONAZOLE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITROARGININE; NOREPINEPHRINE; PROADIFEN; PYRROLES; RATS; RATS, WISTAR; TRIAZOLES; VASODILATOR AGENTS;

EID: 0030754606     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199706000-00018     Document Type: Article

References (31)

1. Vanhoutte PM, ed. Endothelium-derived hyperpolarizing factor. (Endothelial cell research series, vol 1). Amsterdam: Harward Academic publishers, 1996.
2. Cohen RA, Vanhoutte PM. Endothelium-dependent hyperpolarization: beyond nitric oxide and cyclic GMP. Circulation 1995;92:3337-49.
3. Garland CJ, Plane F, Kemp B, Cocks T. Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol Sci 1995;16:23-30.
4. 2+channels. Br J Pharmacol 1996;117:1035-40 .
5. Hwa JJ, Ghibaudi L, Williams P, Chatterjee M. Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed. Am J Physiol 1994;266:H952-8.
6. + channel opened by cromakalim. Br J Pharmacol 1991;103:1184-90.
7. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol 1988;93:515-24.
8. Chen G, Yamamoto Y, Miwa K, Suzuki H. Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances. Am J Physiol 1991;260:H1888-92.
9. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 1996;78:415-23.
10. Hecker M, Bara AT, Bauersachs J, Busse R. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol 1994;481:407-14.
11. Bauersachs J, Hecker M, Busse R. Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary micro-circulation. Br J Pharmacol 1994;113:1548-53.
12. Corriu C, Feletou M, Canet E, Vanhoutte PM. Inhibitors of the cytochrome P450-monooxygenase and endothelium-dependent hyperpolarizations in the guinea-pig carotid artery. Br J Pharmacol 1996;117:607-10.
13. Zygmunt PM, Edwards G, Weston AH, Davis SG, Högestätt D. Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. Br J Pharmacol 1996;118:1147-52.
14. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977;41:19-26.
15. Furchgott RF, Zawadzki JV. The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
16. Singer HA, Saye JA, Peach MJ. Effects of cytochrome P-450 inhibitors on endothelium-dependent relaxation in rabbit aorta. Blood Vessels 1984;21:223-30.
17. Moore SA, Spector AA, Hart MN. Eicosanoid metabolism in cerebromicrovascular endothelium. Am J Physiol 1988;254: C37-44.
18. Pinto A, Abraham NG, Mullane KM. Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway. J Pharmacol Exp Ther 1987;240:856-63.
19. Gebremedhin D, Ma Y-H, Falck JR, Roman RJ, Vanrollins M, Harder DR. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol 1992;263:H519-25.
20. +-channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid. Eur J Pharmacol 1993;230:215-21.
21. Fulton D, Mahboubi K, McGiff JC, Quilley J. Cytochrome P450-dependent effects of bradykinin in the rat heart. Br J Pharmacol 1995;114:99-102.
22. Fulton D, McGiff JC, Quilley J. Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney. Br J Pharmacol 1992;107:722-5.
23. Fujii K, Ohmori S, Tominaga M, et al. Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. Am J Physiol 1993;265:H509-16.
24. Murray M, Reidy GF. Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents. Pharmacol Rev 1990;42:85-101.
25. Bennett BM, McDonald BJ, Nigam R, Long PG, Simon WC. Inhibition of nitrovasodilator- and acetylcholine-induced relaxation and cyclic GMP accumulation by the cytochrome P-450 substrate, 7-ethoxyresorufin. Can J Phvsiol Pharmacol 1992;70: 1297-303.
26. + channels by cytochrome P-450 inhibitors. J Biol Chem 1992;267:11789-93.
27. Edwards G, Zygmunt PM, Högestätt ED, Weston AH. Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br J Pharmacol 1996;119:691-701.
28. + currents in pulmonary arterial myocytes. Am J Physiol 1995;268:C259-70.
29. Mathews JM, Dostal LA, Bend JR. Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J Pharmacol Exp Ther 1985;235:186-90.
30. G-nitro-L-arginine in rat aorta. Eur J Pharmacol 1995;274:25-32.
31. Zou A-P, Ma Y-H, Sui Z-H, et al. Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid ω-hydroxylase, on renal function in rats. J Pharmacol Exp Ther 1994;268:474-81.