Origin and function of epoxyeicosatrienoic acids in vascular endothelial cells: More than just endothelium-derived hyperpolarizing factor?

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 10, 1998, Pages 826-830

  Hoebel, Bernhard G ^a   Steyrer, Ernst ^a   Graier, Wolfgang F ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Bradykinin; Capacitative Ca2+ entry; Cytochrome P450 epoxygenase; Endothelial cells; Endothelium derived hyperpolarizing factor; Tyrosine kinase

Indexed keywords

ARACHIDONIC ACID; BRADYKININ; CALCIUM ION; CLOFIBRATE; CYTOCHROME P450; DEXAMETHASONE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ICOSATRIENOIC ACID; PROTEIN TYROSINE KINASE; THAPSIGARGIN; THIOPENTAL; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; CALCIUM TRANSPORT; CATTLE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMMUNOBLOTTING; MEMBRANE POTENTIAL; NONHUMAN; PROTEIN ELECTROPHORESIS; PROTEIN EXPRESSION; SMOOTH MUSCLE; SWINE; VASCULAR ENDOTHELIUM;

EID: 0031693438     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02162.x     Document Type: Conference Paper

References (27)

1. Busse R, Mülsch A, Flemming I, Hecker M. Mechanisms of nitric oxide release from the vascular endothelium. Circulation 1993; 87 (Suppl. V): V18-25.
2. Feletou MV, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br. J. Pharmacol. 1988; 93: 515-24.
3. Rubany GMV, Vanhoutte PM. Nature of endothelium-derived relaxing factor: Are there two relaxing mediators? Circ. Res. 1987; 61: II61-7.
4. Hecker M, Bara AT, Bauernsachs J, Busse R. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J. Physiol. 1995; 481: 407-14.
5. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 1996; 78: 415-23.
6. G-nitroarginine/indomethacin-resistant relaxation in bovine and porcine coronary arteries. Br. J. Pharmacol. 1996; 119: 1177-86.
7. Gebremedhin D, Ma Y-H, Falck JR, Roman RJ, VanRollins M. Harder DR. Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am. J. Physiol. 1992; 263: H519-25.
8. + channels in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acids. Eur. J. Pharmacol. 1993; 230: 215-21.
9. + channels in coronary smooth muscle through a guanine nucleotide binding protein. Circ. Res. 1997; 80: 877-84.
10. Karara A, Breyer M, Falck JR, Capdevila J. Epoxyeicosatrienoic acids (EETs) elevate cytosolic calcium in isolated rat hepatocytes. FASEB J. 1991; 6: A1053.
11. Madhun ZT, Goldthwait DA, McKay D. Hopfer U, Douglas JG. An epoxygenase metabolite of arachidonic acid mediates angiotensin II-induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells. J. Clin. Invest. 1991; 88: 456-61.
12. 2+ entry. J. Physiol. 1995; 482: 259-74.
13. 2+ entry in porcine aortic endothelial cells. Br. J. Pharmacol. 1997; 121: 1579-88.
14. 2+ signaling in cultured endothelial cells. Cell Calcium 1997; 21: 43-51.
15. i. Biophys. J. 1993; 65: 561-2.
16. Hoebel B, Graier WF. 11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells. Eur. J. Pharmacol. 1998; 346: 115-17.
17. Steyrer E. Durovic S, Frank S et al. The role of lecithin:cholesterol acyltransferase for lipoprotein (a) assembly. J. Clin. Invest. 1994; 94: 2330-40.
18. Edgell CJS, McDonald CC, Graham JB. Permanent cell line expressing factor VIII related antigen established by hybridization. Proc. Natl Acad. Sci. USA 1983; 80: 3734-7.
19. Lin JH-C, Kobari Y, Zhu Y, Stemerman MB, Pritchard KA. Human umbilical vein endothelial cells express P450, 2C8 mRNA. Cloning of endothelial P450 epoxygenase. Endothelium 1995; 4: 219-29.
20. Zeldin DC, Foley J, Ma J et al. CYP2J subfamily P450s in the lung: Expression, localization, and potential functional significance. Mol. Pharmacol. 1996; 50: 1111-17.
21. Irizar A, loannides C. Expression and inducibility of cytochrome P450 proteins belonging to families 2, 3 and 4 in the rabbit aorta. Biochem. Biophys. Res. Commun. 1995; 213: 916-21.
22. Lischke V, Busse R, Hecker M. Selective inhibition by barbiturates of the synthesis of endothelium-derived hyperpolarizing factor in the rabbit carotid artery. Br. J. Pharmacol. 1995; 115: 969-74.
23. Fleming I, Fisslthaler B, Busse R. Calcium signaling in endothelial cells involves activation of tyrosine kinase and leads to activation of mitogen-activated protein kinase. Circ. Res. 1995; 76: 522-9.
24. Fleming I, Fisslthaler B, Busse R. Interdependence of calcium signaling and protein tyrosine phosphorylation in human endothelial cells. J. Biol. Chem. 1996; 271: 11 009-15.
25. Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ. Res. 1996; 79: 984-91.
26. Cui X-L, Douglas JG. Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells. Proc. Nalt Acad. Sci. USA 1997; 94: 3771-6.
27. 2+ regulation and endothelial vascular function. Endothelium 1994; 1: 223-36.