Endothelium-dependent relaxation by substance P in human isolated omental arteries and veins: Relative contribution of prostanoids, nitric oxide and hyperpolarization

British Journal of Pharmacology

Volumn 120, Issue 1, 1997, Pages 25-30

  Wallerstedt, Susanna M ^a   Bodelsson, Mikael ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Human blood vessels; Hyperpolarization; K+ channels; Nitric oxide; Substance P

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; CLOTRIMAZOLE; CYTOCHROME P450 INHIBITOR; GLIBENCLAMIDE; INDOMETACIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; SUBSTANCE P; TETRYLAMMONIUM; THROMBOXANE A2;

ADULT; AGED; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; MUSCLE ISOMETRIC CONTRACTION; OMENTUM; PRIORITY JOURNAL; VEIN DILATATION; VENOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETYLCHOLINE; ADULT; AGED; AGED, 80 AND OVER; ARTERIES; ELECTROPHYSIOLOGY; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; MIDDLE AGED; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PROSTAGLANDINS; SUBSTANCE P; TETRAETHYLAMMONIUM COMPOUNDS; THROMBOXANE A2; VASOCONSTRICTOR AGENTS; VEINS;

EID: 0031037450     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700879     Document Type: Article

References (32)

1. ANDREW, L., McCARTHY, M.B., WOOLFSON, R.G., EVANS, B.J., DAVIES, D.R., RAJU, S.K. & POSTON, L. (1994). Functional characteristics of small placental arteries. Am. J. Obstet. Gynecol., 170, 945-951.
2. ARNER, M., HÖGESTÄTT, E.D. & USKI, T.K. (1991). Characterization of contraction-mediating prostanoid receptors in human hand veins: effects of the thromboxane receptor antagonists BM 13,505 and AH23848. Acta Physiol. Scand., 141, 79-86.
3. BAUERSACHS, J., HECKER, M. & BUSSE, R. (1994). Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic metabolite in the coronary microcirculation. Br. J. Pharmacol., 113, 1548-1553.
4. BODELSSON, G., MARSAL, K. & STJERNQUIST, M. (1995). Reduced contractile effect of endothelin-1 and noradrenalin in human umbilical artery from pregnancies with abnormal umbilical artery flow velocity waveforms. Early Hum. Dev., 42, 15-28.
5. BODELSSON, G. & STJERNQUIST, M. (1994). Endothelium-dependent relaxation to substance P in human umbilical artery is mediated via prostanoid synthesis. Hum. Reprod., 9, 733-737.
6. BODELSSON, M., ARNEKLO-NOBIN, B. & TÖRNEBRANDT, K. (1989). Cooling augments contractile response to 5-hydroxytryptamine via an endothelium-dependent mechanism. Blood Vessels, 26, 347-359.
7. BODELSSON, M., ARNEKLO-NOBIN, B. & TÖRNEBRANDT, K. (1990). Effect of cooling on smooth muscle response to 5-hydroxytryptamine in human hand veins. Acta Physiol. Scand., 140, 331-339.
8. + channel opened by cromakalim, acetylcholine and substance P in rat aorta and porcine coronary artery. Br. J. Pharmacol., 102, 585-594.
9. COLEMAN, R.A., HUMPHREY, P.P.A., KENNEDY, I. & LUMLEY, P. (1984). Prostanoid receptors - the development of a working classification. Trends Pharmacol. Sci., 5, 303-306.
10. EDWARDS, G. & WESTON, A.H. (1994). Effect of potassium channel modulating drugs on isolated smooth muscle. In Handbook of Experimental Pharmacology, ed. Szekeres, L. & Papp, J.G. III, pp. 469-531. Heidelberg: Springer.
11. ENOKIBORI, M., OKAMURA, T. & TODA, N. (1994). Mechanism underlying substance P-induced relaxation in dog isolated superficial temporal arteries. Br. J. Pharmacol., 111, 77-82.
12. FISCUS, R.R., GROSS, D.R. & HAO, H. (1992). N-omega-nitro-L-arginine blocks the second phase but not the first phase of the endothelium-dependent relaxations induced by substance P in isolated rings of pig carotid artery. J. Cardiovasc. Pharmacol., 20 (suppl.12), 105-108.
13. FOLKOW, B. & NEIL, E. (1971). Gastrointestinal and liver circulations. In Circulation. pp.466-467, New York: Oxford University Press.
14. GROSS, D.R., FISCUS, R.R., AREDEN, W.A., MALEY, R.H., LANZO, S. & SALLEY, R.K. (1994). Substance P induces biphasic endothelium-dependent relaxations in pig and rabbit carotid arteries. Neuropeptides, 26, 329-341.
15. + channel in vascular smooth muscle by cytochrome P450 metabolites of arachidonic acid. Eur. J. Pharmacol., 230, 215-221.
16. LISCHKE, V., BUSSE, R. & HECKER, M. (1995). Selective inhibition by barbiturates of the synthesis of endothelium-derived hyperpolarizing factor in the rabbit carotid artery. Br. J. Pharmacol., 115, 969-974.
17. KILPATRICK, E.V. & COCKS, T.M. (1994). Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery. Br. J. Pharmacol., 112, 557-565.
18. MADSEN, G., TOTTRUP, A., ANDERSSON, K-E. & FORMAN, A. (1992). Mechanical effects of some prostanoids on isolated human oesophageal submucosal veins. Pharmacol. Toxicol., 71, 330-334.
19. NAGAO, T. & VANHOUTTE, P.M. (1992). Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery. J. Physiol., 445, 355-367.
20. NOREL, X., LABAT, C., GARDINER, P.J. & BRINK, C. (1991). Inhibitory effects of BAY u3405 on prostanoid-induced contractions in human isolated bronchial and pulmonary arterial muscle preparations. Br. J. Pharmacol., 104, 591-595.
21. ONOUE, H., NAKAMURA, N. & TODA, N. (1988). Endothelium-dependent and -independent responses to vasodilators of isolated dog cerebral arteries. Stroke, 19, 1388-1393.
22. PERNOW, J. (1989). Actions of constrictor (NPY and endothelin) and dilator (substance P, CGRP and VIP) peptides on pig splenic and human skeletal muscle arteries: involvement of the endothelium. Br. J. Pharmacol., 97, 983-989.
23. PETERSSON, J., ZYGMUNT, P.M., BRANDT, L. & HÖGESTÄTT, E.D. (1995). Substance P-induced relaxation and hyperpolarization in human cerebral arteries. Br. J. Pharmacol., 115, 889-894.
24. ROSENBLUM, W.I., SHIMIZU, T. & NELSON, G.H. (1993). Endothelium-dependent effects of substance P and calcitonin gene-related peptide on mouse pial arterioles. Stroke, 24, 1043-1048.
25. SHARMA, N.R. & DAVIS, M.J. (1994). Mechanism of substance P-induced hyperpolarization of porcine coronary artery endothelial cells. Am. J. Physiol., 266, H156-H164.
26. TADJKARIMI, S., O'NEIL, G.S., SCHYNS, C.H., BORLAND, J.A., CHESTER, A.H. & YACOUB, M.H. (1993). Vasoconstrictor profile of the inferior epigastric artery. Ann. Thorac. Surg., 56, 1090-1095.
27. TAYLOR, S.G. & WESTON, A.H. (1988). Endothelium-derived hyperpolarization factor: a new endogenous inhibitor from the vascular endothelium. Trends Pharmacol. Sci., 9, 272-274.
28. TÖRNEBRANDT, K., NOBIN, A. & OWMAN, C. (1987). Vasomotor effects of nine neuropeptides on isolated human mesenteric blood vessels. Peptides, 8, 251-256.
29. WATSON, S. & GIRDLESTONE, D. (1996). 1996 Receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci., 17 (suppl.), 72-77.
30. ZHANG, G., YAMAMOTO, Y., MIWA, K. & SUZUKI, H. (1994). Vasodilatation induced by substance P in guinea pig carotid arteries. Am. J. Physiol., 266, H1132-H1137.
31. ZYGMUNT, P.M., GRUNDEMAR, L. & HÖGESTÄTT, E.D. (1994a). Endothelium-dependent relaxation resistant to N-omega-nitro-L-arginine in the rat hepatic artery and aorta. Acta Physiol. Scand., 152, 107-114.
32. ZYGMUNT, P.M., WALDECK, K. & HÖGESTÄTT, E.D. (1994b). The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery. Acta Physiol. Scand., 152, 375-384.