The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication

Journal of Physiology

Volumn 520, Issue 2, 1999, Pages 539-550

  Chaytor, A T ^a   Martin, P E M ^a   Evans, W H ^a   Randall, M D ^b   Griffith, T M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

18ALPHA GLYCYRRHETINIC ACID; 4 [6 METHOXY 2 (4 METHOXYPHENYL) 3 BENZOFURANYLCARBONYL]BENZONITRILE; ANANDAMIDE; ARACHIDONIC ACID; CANNABINOID; CANNABINOID RECEPTOR ANTAGONIST; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GAP JUNCTION PROTEIN; INDOMETACIN; LUCIFER YELLOW; METHANANDAMIDE; N (4 HYDROXYPHENYL)ARACHIDONYLETHANOLAMIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN SYNTHASE; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID 1 RECEPTOR; CONNEXIN 40; CONNEXIN 43; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; N(G) NITROARGININE METHYL ESTER;

ANIMAL TISSUE; ARTICLE; CELL JUNCTION; CONTROLLED STUDY; CYTOSOL; DIFFUSION; ENZYME INHIBITION; FIBROBLAST; GAP JUNCTION; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; SUPERIOR MESENTERIC ARTERY; VASCULAR ENDOTHELIUM; VASODILATATION; ANIMAL CELL; ARTERY RELAXATION; BLOOD VESSEL PARAMETERS; CELL COMMUNICATION; ENDOTHELIUM CELL; HEART MUSCLE RELAXATION; HYPERPOLARIZATION; MESENTERIC ARTERY; NEW ZEALAND WHITE (RABBIT);

ACETYLCHOLINE; ANIMALS; ARACHIDONIC ACIDS; BENZOFURANS; CANNABINOIDS; COS CELLS; ENDOCANNABINOIDS; GAP JUNCTIONS; GLYCYRRHETINIC ACID; INDOMETHACIN; ISOQUINOLINES; MALE; MESENTERIC ARTERY, SUPERIOR; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; PHENYLEPHRINE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RABBITS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0033569702     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.00539.x     Document Type: Article

References (47)

1. ABADJI, V., LIN, S., TAHA, G., GRIFFIN, G., STEVENSON, L. A., PERTWEE, R. G. & MAKRIYANNIS, A. (1994). (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. Journal of Medicinal Chemistry 37, 1889-1893.
2. ADEAGBO, A. S. & HENZEL, M. K. (1998). Calcium-dependent phospholipase A2 mediates the production of endothelium-derived hyperpolarizing factor in perfused rat mesenteric prearteriolar bed. Journal of Vascular Research 35, 27-35.
3. BELTRAMO, M., STELLA, N., CALIGNANO, A., LIN, S. Y., MAKRIYANNIS, A. & PIOMELLI, D. (1997). Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277, 1094-1097.
4. BÉNY, J.-L. & PACICCA, C. (1994). Bidirectional electrical communication between smooth muscle and endothelial cells in the pig coronary artery. American Journal of Physiology 266, H1465-1472.
5. BILFINGER, T. V., SALZET, M., FIMIANI, C., DEUTSCH, D. G., TRAMU, G. & STEFANO, G. B. (1998). Pharmacological evidence for anandamide amidase in human cardiac and vascular tissues. International Journal of Cardiology 64, S15-22.
6. CALIGNANO, A., LA RANA, G., BELTRAMO, M., MAKRIYANNIS, A. & PIOMELLI, D. (1997). Potentiation of anandamide hypotension by the transport inhibitor, AM404. European Journal of Pharmacology 337, R1-2.
7. CAMPBELL, W. B., GEBREMEDHIN, D., PRATT, P. F. & HARDER, D. R. (1996). Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circulation Research 78, 415-423.
8. 3. Journal of Cell Science 109, 1765-1773.
9. CHAYTOR, A. T., EVANS, W. H. & GRIFFITH, T. M. (1997). Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. Journal of Physiology 503, 99-110.
10. CHAYTOR, A. T., EVANS, W. H. & GRIFFITH, T. M. (1998). Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. Journal of Physiology 508, 561-573.
11. DAVIDSON, J. S. & BAUMGARTEN, I. M. (1988). Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap junctional intercellular communication. Structure-activity relationships. Journal of Pharmacology and Experimental Therapeutics 246, 1104-1107.
12. DEUTSCH, D. G., GOLIGORSKY, M. S., SCHMID, P. C., KREBSBACH, R. J., SCHMID, H. H., DAS, S. K., DEY, S. K., ARREAZA, G., THORUP, C., STEFANO, G. & MOORE, L. C. (1997). Production and physiological actions of anandamide in the vasculature of the rat kidney. Journal of Clinical Investigation 100, 1538-1546.
13. DORA, K. A., MARTIN, P. E. M., CHAYTOR, A. T., EVANS, W. H., GARLAND, C. J. & GRIFFITH, T. M. (1999). Role of heterocellular gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptide. Biochemical and Biophysical Research Communications 254, 27-31.
14. ELFGANG, C., ECKERT, R., LICHTENBERG-FRATE, H., BUTTERWECK, A., TRAUB, O., KLEIN, R. A., HULSER, D. F. & WILLECKE, K. (1995). Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. Journal of Cell Biology 129, 805-817.
15. ELLIS, E. F., MOORE, S. F. & WILLOUGHBY, K. A. (1995). Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin. American Journal of Physiology 269, H1859-1864.
16. FELDER, C. C., JOYCE, K. E., BRILEY, E. M., GLASS, M., MACKIE, K. P., FAHEY, K. J., CULLINAN, G. J., HUNDEN, D. C., JOHNSON, D. W., CHANEY, M. O., KOPPEL, G. A. & BROWNSTEIN, M. (1998). LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. Journal of Pharmacology and Experimental Therapeutics 284, 291-297.
17. FULTON, D., MCGIFF, J. C. & QUILLEY, J. (1996). Role of phospholipase C and phospholipase A2 in the nitric oxide-independent vasodilator effect of bradykinin in the rat perfused heart. Journal of Pharmacology and Experimental Therapeutics 278, 518-526.
18. GEORGE, C. H., KENDALL, J. M., CAMPBELL, A. K. & EVANS, W. H. (1998). Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells. Journal of Biological Chemistry 273, 29822-29829.
19. HECKER, M., BARA, A. T., BAUERSACHS, J. & BUSSE, R. (1994). Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. Journal of Physiology 481, 407-414.
20. 2. Circulation Research 84, 53-63.
21. LI, X. & SIMARD, J. M. (1996). Multiple connexins form gap junction channels in rat basilar artery smooth muscle cells. Circulation Research 84, 1277-1284.
22. LITTLE, T. L., XIA, J. & DULING, B. R. (1995). Dye tracers define differential endothelial and smooth muscle coupling patterns within the arteriolar wall. Circulation Research 76, 498-504.
23. MARCHENKO, S. M. & SAGE, S. O. (1993). Electrical properties of resting and acetylcholine-stimulated endothelium in intact rat aorta. Journal of Physiology 462, 735-751.
24. MEHRKE, G. & DAUT, J. (1990). The electrical response of cultured guinea-pig coronary endothelial cells to endothelium-dependent vasodilators. Journal of Physiology 430, 251-272.
25. MOMBOULI, J. V., BISSIRIOU, I., AGBOTON, V. D. & VANHOUTTE, P. M. (1996). Bioassay of endothelium-derived hyperpolarizing factor. Biochemical and Biophysical Research Communications 221, 484-488.
26. MOMBOULI, J.-V. & VANHOUTTE, P. M. (1997). Endothelium-derived hyperpolarizing factor(s): updating the unknown. Trends in Pharmacological Sciences 18, 252-256.
27. MUNARI-SILEM, Y., LEBRETHON, M. C., MORAND, I., ROUSSET, B. & SAEZ, J. M. (1995). Gap junction-mediated cell-to-cell communication in bovine and human adrenal cells. A process whereby cells increase their responsiveness to physiological corticotropin concentrations. Journal of Clinical Investigation 95, 1429-1439.
28. NADARAJAH, B., MAKARENKOVA, H., BECKER, D. L., EVANS, W. H., PARNAVELAS, J. G. (1998). Basic FGF increases communication between cells of the developing neocortex. Journal of Neuroscience 18, 7881-7890.
29. PETERSSON, J., ZYGMUNT, P. M. & HOGESTATT, E. D. (1997). Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries. British Journal of Pharmacology 120, 1344-1350.
30. PLANE, F., HOLLAND, M., WALDRON, G. J., GARLAND, C. J. & BOYLE, J. P. (1997). Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. British Journal of Pharmacology 121, 1509-1511.
31. PRATT, P. F., HILLARD, C. J., EDGEMOND, W. S. & CAMPBELL, W. B. (1998). N-Arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. American Journal of Physiology 274, H375-381.
32. RANDALL, M. D., ALEXANDER, S. P., BENNETT, T., BOYD, E. A., FRY, J. R., GARDINER, S. M., KEMP, P. A., MCCULLOCH, A. I. & KENDALL, D. A. (1996). An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochemical and Biophysical Research Communications 229, 114-120.
33. RANDALL, M. D. & KENDALL, D. A. (1997). Involvement of a cannabinoid in endothelium-derived hyperpolarizing factor-mediated coronary vasorelaxation. European Journal of Pharmacology 335, 205-209.
34. RANDALL, M. D. & KENDALL, D. A. (1998). Endocannabinoids: a new class of vasoactive substances. Trends in Pharmacological Sciences 19, 55-58.
35. RANDALL, M. D., MCCULLOCH, A. I. & KENDALL, D. A. (1997). Comparative pharmacology of endothelium-derived hyperpolarizing factor and anandamide in rat isolated mesentery. European Journal of Pharmacology 333, 191-197.
36. SCHMILINSKY-FLURI, G., VALIUNAS, V., WILLI, M. & WEINGART, R. (1997). Modulation of cardiac gap junctions: the mode of action of arachidonic acid. Journal of Molecular and Cellular Cardiology 29, 1703-1713.
37. SPAGNOLI, L. G., VILLASCHI, S., NERI, L. & PALMIERI, G. (1982). Gap junctions in myo-endothelial bridges of rabbit carotid arteries. Experientia 38, 124-125.
38. TAYLOR, H. J., CHAYTOR, A. T., EVANS, W. H. & GRIFFITH, T. M. (1998). Inhibition of the gap junctional component of endothelium-dependent relaxations in rabbit iliac artery by 18-α-glycyrrhetinic acid. British Journal of Pharmacology 125, 1-4.
39. VENANCE, L., PIOMELLI, D. & GLOWINSKI, J. & GIAUME, C. (1995). Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature 376, 590-594.
40. WAGNER, J. A., VARGA, K., JARAI, Z. & KUNOS, G. (1999). Mesenteric vasodilation mediated by endothelial anandamide receptors. Hypertension 33, 429-434.
41. WARNER, A., CLEMENTS, D. K., PARIKH, S., EVANS, W. H. & DEHAAN, R. L. (1995). Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes. Journal of Physiology 488, 721-728.
42. m-sensitive gating mechanism. Pflügers Archiv 435, 301-309.
43. WHITE, R. & HILEY, C. R. (1997). A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. British Journal of Pharmacology 122, 1573-1584.
44. YAMAMOTO, Y., IMAEDA, K. & SUZUKI, H. (1999). Endothelium-dependent hyperpolarization and intercellular electrical coupling in guinea-pig mesenteric arterioles. Journal of Physiology 514, 505-513.
45. YEAGER, M. & NICHOLSON, B. J. (1996). Structure of gap junction intercellular channels. Current Opinion in Structural Biology 6, 183-192.
46. ZYGMUNT, P. M., EDWARDS, G., WESTON, A. H., LARSSON, B. & HÖGESTÄTT, E. D. (1997a). Involvement of voltage-dependent potassium channels in the EDHF-mediated relaxation of rat hepatic artery. British Journal of Pharmacology 121, 141-149.
47. ZYGMUNT, P. M., HÖGESTÄTT, E. D., WALDECK, K., EDWARDS, G., KIRKUP, A. J. & WESTON, A. H. (1997b). Studies on the effects of anandamide in rat hepatic artery. British Journal of Pharmacology 122, 1679-1686.