Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 6880-6888

  Airoldi, I ^a   Gri, G ^a   Marshall, J D ^a   Corcione, A ^a   Facchetti, P ^a   Guglielmino, R ^a   Trinchieri, G ^a   Pistoia, V ^a  

^a G GASLINI INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18 RECEPTOR; RNA; STAT PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; B LYMPHOCYTE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOID TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; TONSIL;

EID: 0034672090     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.6880     Document Type: Article

References (60)

1. Interleukin-12 a proinflammatory cytokine with immuno-regulatory functions that bridges innate resistance and antigen-specific adaptive immunity
2. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokane with multiple biologic effects on human lymphocytes
3. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
4. Cloning of cDNA for natural killer stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural loller cells
5. Interleukin 12 induces stable priming for interferon gamma (IFN-γ) production during differentiatioon of human T helper (Th) cells and transient IFN-γ production in established Th2 clones
6. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
7. + T cells
8. Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signal CD40 ligand, interferon γ, and IL-10: Role of B cells in the maintenance of T cell responses
9. Differentiation of human NK cells into NK1 and NK2 subsets
10. Expression cloning of a human IL-12 receptor component
11. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
12. IL-12 receptor II Distribution and regulation of receptor expression
13. Regulation of IL-12 receptor β1 chain expression and IL-12 binding by human peripheral blood mononuclear cells
14. Regulation of the interleukin (IL)-12Rβ2 subunit expression
15. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
16. + T cells by costimulation with B7-B2 molecules
17. Antibodies to the IL-12 receptor β2 chain mark human Th1 but not Th2 cells in vitro and in vivo
18. IL-12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes
19. Activation of STAT4 by IL-12 and IFN-α evidence for the involvement of ligand-induced tyrosine and serine phosphorylation
20. Regulation of IL-12 receptor in early T-helper responses implies two phases of Th1 differentiation capacitance and development
21. Requirement for STAT-4 in interleukin-12-mediated responses of natural killer and T cells
22. Impaired IL-12 responses and enhanced development of Th2 cells in STAT4 deficient mice
23. JAKs and STATs biological implications
24. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production
25. The effects of IL12 on B cell subset function
26. Inhibition of murine B1 lymphocytes by interleukin-12
27. Effect of IL-12 neutralizing anti-cytokine antibodies on in vitro activation of B-cells interleukin-12 is required by Bla but not B2 cells
28. Role of IL-12 in human B lymphocyte proliferation and differentiation
29. Interleukin-12 stimulates B cell growth by reducing IFN-γ
30. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes
31. Direct binding of IL-12 to human and murine B lymphocytes
32. IL-12 expression in AIDS-related lymphoma B cell lines
33. Cloning of a new cytokine that induces IFN-γ production by T cells
34. Production of IL-18 (IFN-γ inducing factor) messenger RNA and functional protein by murine keratinocytes
35. Induction of IFN-γ inducing factor in the adrenal cortex
36. IL-18 accounts for both TNF-α and FasL-mediated hepatotoxic pathways in endotoxin-induced liver injury
37. Caspase-1 processes IFN-γ inducing factor and regulates LPS-induced IFN-γ production
38. Activation of IFN-γ inducing factor mediated by interleukin-1 β converting enzyme
39. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells synergism with IL-18 for IFN-γ production
40. + T lymphocytes
41. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB
42. Interaction of NF-κB and NFAT with the interferon-γ promoter
43. Purification and characterization of the human interleukin-18 receptor
44. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
45. Constitutive and induced IL-18 receptor expression by various peripheral blood cell subsets as determined by anti-hIL-18R monoclonal antibody
46. - B cell compartment identification of two major tonsillar B cell subsets
47. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
48. NFκB and Rel proteins evolutionary conserved mediators of immune responses
49. Mechanism of antigen-driven selection in germinal centers
50. Maturation of immune responses in germinal centers
51. Expansion, selection and mutartan of antigen-specific B cells in germinal centers
52. Germinal centers
53. Analysis of somatic mutation in five B cell subsets of human tonsil
54. Microanatomy of lymphoid tissues during humoral immune responses structure function relationships
55. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cell by rapid up-regulation of B7-1 and B7-2
56. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes
57. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection
58. Expression of granulocyte colony-stimulating factor and granulocyte colony-stimulating factor receptor genes in partially overlapping monoclonal B-cell populations from chronic lymphocytic leukemia patients
59. B-cell superantigens
60. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation a feedback regulation of Th1 development