Expression of murine IL-12 is regulated by translational control of the p35 subunit

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 4069-4078

  Babik, Jennifer M ^a   Adams, Elizabeth ^a   Tone, Yukiko ^a   Fairchild, Paul J ^a   Tone, Masahide ^a   Waldmann, Herman ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; MESSENGER RNA; PROTEIN P40;

ANIMAL CELL; ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DNA FLANKING REGION; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

EID: 0033120525     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Trinchieri, G. 1995. Interleukin 12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
2. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
3. + T cells. J. Immunol. 154:5071.
4. Heufler, C., F. Koch, U. Stanzl, G. Topar, M. Wysocka, G. Trinchieri, A. Enk. R. M. Steinman, N. Romani, and G. Schüler. 1996. Interleukin-12 is produced by dendritic cells and mediates T helper I development as well as interferon-γ production by T helper I cells. Eur. J. Immunol. 26:659.
5. Sypek, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin-12 initiates a protective T helper type I immune response. J. Exp. Med. 177:1797.
6. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin-12 is required for the T lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
7. Shu, U., M. Kiniwa, C. Y. Wu, C. Maliszewski, N. Vezzio, J. Hakimi, M. Gately, and G. Delespesse. 1995. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1125.
8. Gately, M. K., L. M. Renzetti, J. Magram, A. S. Stern, L. Adorini, U. Gubler, and D. H. Presky. 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:495.
9. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), acytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
10. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, et al. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143.
11. Bette, M., J. Shen-Chu, T. Germann, M. K.-H. Schäfer, E. Weihe, E. Rüde, and B. Fleischer. 1994. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 24:2435.
12. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646.
13. Snijders, A., C. M. U. Hilkens, T. C. T. M. van der Pouw Kraan, M. Engel, L. A. Aarden, and M. L. Kapsenberg. 1996. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156:1207.
14. Aste-Amezaga, M., X. Ma, A. Sartori, and G. Trinchieri. 1998. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J. Immunol. 160: 5936.
15. Chong, C., K. L. Bost, and J. D. Clements. 1996. Differential production of IL-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infect. Immun. 64:1154.
16. Kincy-Cain, T., and K. L. Bost. 1997. Substance P-induced IL-12 production by murine macrophages. J. Immunol. 158:2334.
17. Aloisi, F., G. Penna, J. Cerase, B. M. Iglesias, and L. Adorini. 1997. IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol. 159:1604.
18. Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258.
19. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147.
20. Ma, X., M. Neurath, G. Gri, and G. Trinchieri. 1997. Identification and characterization of a novel ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J. Biol. Chem. 272:10389.
21. Taki, S., T. Sato, K. Ogasawara, T. Fukuda, M. Sato, S. Hida, G. Suzuki, M. Mitsuyama, E. Shin, S. Kojima, et al. 1997. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 6:673.
22. Seharton-Kersten, T., C. Contursi, A. Masumi, A. Sher, and K. Ozato. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186:1523.
23. Plevy, S. E., J. H. M. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572.
24. Schoenhaut, D. S., A. O. Chua, A. G. Wolitzky, P. M Quinn, C. M. Dwyer, W. McComas, P. C. Familletti, M. K. Gately, and U. Gubler. 1992. Cloning and expression of murine IL-12. J. Immunol. 148:3433.
25. Tone, Y., S. A. J. Thompson, J. M. Babik, K. F. Nolan, M. Tone, C. Raven, and H. Waldmann. 1996. Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. Eur. J. Immunol. 26:1222.
26. Yoshimoto, T., K. Kojima, T. Funakoshi, Y. Endo, T. Fujita, and H. Nariuchi. 1996. Molecular cloning and characterization of murine IL-12 genes. J. Immunol. 156:1082.
27. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
28. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
29. Tone, M., S. A. J. Thompson, Y. Tone, P. J. Fairchild, and H. Waldmann. 1997. Regulation of IL-18 (IFN-γ-inducing factor) gene expression. J. Immunol. 159: 6156.
30. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger mRNAs. Nucleic Acids Res. 15:8125.
31. Kozak, M. 1991. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115:887.
32. Frohman, M. A., M. K. Dush, and G. R. Martin. 1988. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85:8998.
33. Baier, M., N. Bannert, A. Werner, K. Lang, and R. Kurth. 1997. Molecular cloning, sequence, expression, and processing if the interleukin 16 precursor. Proc. Natl. Acad. Sci. USA 94:5273.
34. Adam, M. F., A. Belmouden, P. Binisti, A. P. Brézin, F. Valtot, A. Béchetoille, J. Dascotte, B. Copin, L. Gomez, A. Chaventré, et al. 1997. Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma. Hum. Mol. Genet. 6:2091.
35. Kelleher, P., and S. C. Knight. 1998. IL-12 increases CD80 expression and the stimulatory capacity of bone marrow-derived dendritic cells. Int. Immunol. 10: 749.
36. Garnier, G., A Circolo, and H. R. Colten. 1995. Transnational regulation of murine complement factor B alternative transcripts by upstream AUG codons. J. Immunol. 154:3275.
37. Bamford, R. N., A P. Battiata, J. D. Burton, H. Sharma, and T. A. Waldmann. 1996. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/ IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 translation. Proc. Natl. Acad. Sci. USA 93:2897.
38. Bost, K. L., and J. D. Clements. 1997. Intracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages. Infect. Immun. 65:3186.
39. Stalder, A. K., A. Pagenstecher, N. Chen Yu, C. Kincaid, C. Chiang, M. V. Hobbs, F. E. Bloom, and I. L. Campbell. 1997. Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia. J. Immunol. 159:1344.
40. Galbiati, F., L. Rogge, J. C. Guery, S. Smiroldo, and L. Adorini. 1998. Regulation of the IL-12 receptor β2 subunit by soluble antigen and IL-12 in vivo. Eur. J. Immunol. 28:209.
41. Brunvand, M. W., A. Krumm, and M. Groudine. 1993. In vivo footprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells. Nucleic Acids Res. 21:4824.
42. Agarwal, S., and R. Anjana. 1998. Long-range transcriptional regulation of cytokine gene expression. Curr. Opin. Immunol. 10:345.
43. Merberg, D. M., S. F. Wolf, and S. C. Clark. 1992. Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol. Today 13:77.
44. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewick, et al. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074.
45. Fan, X., V. Sibalic, E. Niederer, and R. P. Wuthrich. 1996. The proinflammatory cytokine interleukin-12 occurs as a cell membrane-bound form on macrophages. Biochem. Biophys. Res. Commun. 225:1063.