Prostaglandin E2 and tumor necrosis factor α cooperate to activate human dendritic cells: Synergistic activation of interleukin 12 production

Journal of Experimental Medicine

Volumn 186, Issue 9, 1997, Pages 1603-1608

  Rieser, Claudia ^a   Böck, Günther ^b   Klocker, Helmut ^a   Bartsch, Georg ^a   Thurnher, Martin ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BUCLADESINE; CYCLIC AMP; FORSKOLIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MANNOSE RECEPTOR; MEMBRANE ANTIGEN; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL STIMULATION; CONTROLLED STUDY; DENDRITIC CELL; ENDOCYTOSIS; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; BUCLADESINE; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIC AMP; DENDRITIC CELLS; DINOPROSTONE; DRUG SYNERGISM; FORSKOLIN; HUMANS; INTERLEUKIN-12; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1842332654     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.9.1603     Document Type: Article

References (37)

1. Fearon, D.T., and R.M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science (Wash. DC). 272:50-53.
2. Portanova, J.P., Y. Zhang, G.D. Anderson, S.D. Hauser, J.L. Masferrer, K. Seibert, S.A. Gregory, and P.C. Isakson. 1996. Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. J. Exp. Med. 184:883-891.
3. Garrison, J.C. 1990. Histamin, bradykinin, 5-hydroxytryptamine and their antagonists. In The Pharmacological Basis of Therapeutics. A. Gilman, T.W. Rall, A.S. Nies, and P. Taylor, editors. Pergamon Press, New York. 574-599.
4. Moncada, S., R.M. Palmer, and E.A. Higgs. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142.
5. Vane, J.R., and R.M. Botting. 1994. Biological properties of cyclooxgenase products. In The Handbook of Immunopharmacology. F.M. Cunningham, editor. Academic Press, London. 61-97.
6. Williams, T.J., and J. Morley. 1973. Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature (Lond.). 246:215-217.
7. Moncada, S., S.H. Ferreira, and J.R. Vane. 1973. Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature (Lond.). 246:217-219.
8. van der Pouw Kraan, T.C., L.C. Boeije, R.J. Smeenk, J. Wijdenes, and L.A. Aarden. 1995. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775-779.
9. Strassmann, G., V. Patil Koota, F. Finkelman, M. Fong, and T. Kambayashi. 1994. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med. 180:2365-2370.
10. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
11. Cella, M., F. Sallusto, and A. Lanzavecchia. 1997. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9:10-16.
12. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cyokines and bacterial products. J. Exp. Med. 182:389-400.
13. Thurnher, M., R. Ramoner, G. Gastl, C. Radmayr, G. Böck, M. Herold, H. Klocker, and G. Bartsch. 1997. Bacillus Calmette-Guérin mycobacteria stimulate human blood dendritic cells. Int. J. Cancer. 70:128-134.
14. Verhasselt, V., C. Buelens, F. Willems, D. DeGroote, N. Haeffner-Cavaillon, and M. Goldman. 1997. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells - evidence for a soluble CD14-dependent pathway. J. Immunol. 158:2919-2925.
15. Austyn, J.M. 1996. New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 183:1287-1292.
16. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109-1118.
17. Romani, N., S. Gruner, D. Brang, E. Kämpgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P.O. Fritsch, R.M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83-93.
18. DeKruyff, R.H., R.S. Gieni, and D.T. Umetsu. 1997. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 158:359-366.
19. Romani, N., D. Reider, M. Heuer, S. Ebner, E. Kämpgen, B. Eibl, D. Niederwieser, and G. Schuler. 1996. Generation of mature dendritic cells from human blood: an improved method with special regard to clinical applicability. J. Immunol. Methods. 196:137-151.
20. Bender, A., M. Sapp, G. Schuler, R.M. Steinman, and N. Bhardwaj. 1996. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods. 196:121-135.
21. Caux, C., C. Massacrier, B. Vanbervliet, B. Dubois, C. Van Kooten, I. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263-1272.
22. Zhou, L.J., and T.F. Tedder. 1996. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl. Acad. Sci. USA. 93:2588-2592.
23. Thurnher, M., C. Papesh, R. Ramoner, G. Gastl, G. Böck, C. Radmayr, H. Klocker, and G. Bartsch. 1997. In vitro generation of CD834+ human blood dendritic cells for the active tumor immunotherapy. Exp. Hematol. (NY). 25:232-237.
24. Phipps, R.P., S.H. Stein, and R.L. Roper. 1991. A new view of prostaglandin E regulation of the immune response. Immunol. Today. 12:349-352.
25. Lorenz, J.J., P.J. Furdon, J.D. Taylor, M.W. Verghese, G. Chandra, T.A. Kost, S.A. Haneline, L.A. Roner, and J.G. Gray. 1995. A cyclic adenosine 3′,5′-monophosphate signal is required for the induction of IL-1 beta by TNF-α in human monocytes. J. Immunol. 155:836-844.
26. Sallusto, F., C. Nicolo, R. De Maria, S. Corinti, and R. Testi. 1996. Ceramide inhibits antigen uptake and presentation by dendritic cells. J. Exp. Med. 184:2411-2416.
27. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
28. Cella, M., D. Scheidegger, K. Palmer Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747-752.
29. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heutler, E. Kämpgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741-746.
30. Snijdewint, F.G., P. Kalinski, E.A. Wierenga, J.D. Bos, and M.L. Kapsenberg, 1993. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150:5321-5329.
31. Katamura, K., N. Shintaku, Y. Yamauchi, T. Fukui, Y. Ohshima, M. Mayumi, and K. Furusho. 195. Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-γ and IL-2, but not IL-4 and IL-5. J. Immunol. 155:4604-4612.
32. Hilkens, C.M., A. Snijders, H. Vermeulen, P.H. van der Meide, E.A. Wierenga, and M.L. Kapsenberg. 1996. Accessory cell-derived IL-12 and prostaglandin E2 determine the IFN-γ level of activated human CD4+ T cells. J. Immunol. 156:1722-1727.
33. Seitz, M., and W. Hunstein. 1985. Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus. Ann. Rheum. Dis. 44:438-445.
34. Firestein, G.S., J.M. Alvaro Gracia, R. Maki, and J.M. Alvaro Garcia. 1990. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J. Immunol. 144:3347-3353.
35. Schlaak, J.F., I. Pfers, K.H. Meyer Zum Büschenfelde, and E. Marker Hermann. 1996. Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies. Clin. Exp. Rheumatol. 14:155-162.
36. Fan, X., B. Oertli, and R.P. Wuthrich. 1997. Up-regulauon of tubular epithelial interleukin-12 in autoimmune MRL-Fas(lpr) mice with renal injury. Kidney Int. 51:79-86.
37. Huang, F.P., G.J. Feng, G. Lindop, D.I. Stott, and F.Y. Liew. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lpr/lpr mice. J. Exp. Med. 183:1447-1459.