Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide

Blood

Volumn 94, Issue 5, 1999, Pages 1717-1726

  Wittmann, Miriam ^a   Larsson, Vivi Ann ^a   Schmidt, Petra ^a   Begemann, Gabriele ^a   Kapp, Alexander ^a   Werfel, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN P40; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOREGULATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033198660     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.5.1717     Document Type: Article

References (45)

1. Germann T, Rude E: Interleukin-12. Int Arch Allergy Immunol 108:103, 1995
2. Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 88:4143, 1991
3. Hayes MP, Wang J, Norcross MA: Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646, 1995
4. Ling P, Gately MK, Gubler U, Stern AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J: Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol 154:116, 1995
5. Gately MK, Desai BB, Wolitzky AG, Quinn PM, Dwyer CM, Podlaski FJ, Familletti PC, Sinigaglia F, Chizonnite R, Gubler U: Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 147:874, 1991
6. Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM: Development of TH1 CD4+ T-cells through IL-12 produced by Listeria-induced macrophages. Science 260:547, 1993
7. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 146:3074, 1991
8. Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, Romagnani S: Natural killer cell stimulatory factor (interleukin 12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 177:1199, 1993
9. Trinchieri G: Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 14:335, 1993
10. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 176:1387, 1992
11. Skeen MJ, Miller MA, Shinnick TM, Ziegler HK: Regulation of murine macrophage JL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J Immunol 156:1196, 1996
12. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 178:1041, 1993
13. Snijders A, Hilkens CM, Van der Pouw Kraan TC, Engel M, Aarden LA, Kapsenberg ML: Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 156:1207, 1996
14. Van der Pouw Kraan TC, Boeije LC, Snijders A, Smeenk RJ, Wijdenes J, Aarden LA: Regulation of IL-12 production by human monocytes and the influence of prostaglandin E2. Ann N Y Acad Sci 795:147, 1996
15. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G: Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 181:537, 1995
16. Zerbini M, Gibellmi D, Musiani M, Venturoli S, Gallinella G, Gentilomi G: Automated detection of digoxigenin-labelled B19 parvovirus amplicons by a capture hybridization assay. J Virol Methods 55:1, 1995
17. Jung T, Schauer U, Heusser C, Neumann C, Rieger C: Detection of intracellular cytokines by flow cytometry. J Immunol Methods 159:197, 1993
18. Ma X, Chow JM, Gri G, Carra G, Gerosa F, Wolf SF, Dzialo R, Trinchieri G: The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 183:147, 1996
19. Freudenberg MA, Galanos C: Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect Immun 56:1352, 1988
20. Bogdan C, Vodovotz Y, Paik J, Xie QW, Nathan C: Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages. J Immunol 151:301, 1993
21. Granowitz EV, Porat R, Mier JW, Orencole SF, Kaplanski G, Lynch EA, Ye K, Vannier E, Wolff SM, Dinarello CA: Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans. J Immunol 151:1637, 1993
22. Mackensen A, Galanos C, Wehr U, Engelhardt R: Endotoxin tolerance: Regulation of cytokine production and cellular changes in response to endotoxin application in cancer patients. Eur Cytokine Netw 3:571, 1992
23. Mengozzi M, Fantuzzi G, Sironi M, Bianchi M, Fratelli M, Peri G, Bernasconi S, Ghezzi P: Early down-regulation of TNF production by LPS tolerance in human monocytes: Comparison with IL-1 beta, IL-6, and IL-8. Lymphokine Cytokine Res 12:231, 1993
24. Takasuka N, Tokunaga T, Akagawa KS: Preexposure of macrophages to low doses of lipopolysaccharide inhibits the expression of tumor necrosis factor-alpha mRNA but not of IL-1 beta mRNA. J Immunol 146:3824, 1991
25. Zhang X, Morrison DC: Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages. J Exp Med 177:511, 1993
26. Ziegler-Heitbrock HW, Frankenberger M, Wedel A: Tolerance to lipopolysaccharide in human blood monocytes. Immunobiology 193: 217, 1995
27. Ziegler-Heitbrock HW, Blumenstein M, Kafferlein E, Kieper D, Petersmann I, Endres S, Flegel WA, Northoff H, Riethmuller G, Haas JG: In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion. Immunology 75:264, 1992
28. Randow F, Syrbe U, Meisel C, Krausch D, Zuckermann H, Platzer C, Volk HD: Mechanism of endotoxin desensitization: Involvement of interleukin 10 and transforming growth factor beta. J Exp Med 181:1887, 1995
29. Lauener RP, Goyert SM, Geha RS, Vercelli D: Interleukin 4 down-regulates the expression of CD14 in normal human monocytes. Eur J Immunol 20:2375, 1990
30. Hilkens CM, Snijders A, Vermeulen H, van der Meide PH, Wierenga EA, Kapsenberg ML: Accessory cell-derived IL-12 and prostaglandin E2 determine the IFN-gamma level of activated human CD4+ T-cells. J Immunol 156:1722, 1996
31. Tannenbaum CS, Major JA, Hamilton TA: IFN-gamma and lipopolysaccaride differentially modulate expression of tumor necrosis factor receptor mRNA in murine peritoneal macrophages. J Immunol 151:6833, 1993
32. Rothe H, Hartmann B, Geerlings P, Kolb H: Interleukin-12 gene-expression of macrophages is regulated by nitric oxide. Biochem Biophys Res Commun 224:159, 1996
33. Fahmi H, Charon D, Mondange M, Chaby R: Endotoxin-induced desensitziation of mouse macrophages is mediated in part by nitric oxide production. Infect Immun 63:1863, 1995
34. Hodge-Dufour J, Marino MW, Horton MR, Jungbluth A, Burdick MD, Strieter RM, Noble PW, Hunter CA, Pure E: Inhibition of Interferon gamma induced interleukin 12 production: A potential mechanism of the anti-inflammatory activities of tumor necrosis factor. Proc Natl Acad Sci USA 95:13806, 1998
35. Huang FP, Niedbala W, Wei XQ, Xu D, Feng GJ, Robinson JH, Lam C, Liew FY: Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur J Immunol 28:4062, 1998
36. Mattner F, Fischer S, Guckes S, Jin S, Kaulen H, Schmitt E, Rude E, Germann T: The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur J Immunol 23:2202, 1993
37. Karp CL, Wysocka M, Ma X, Marovich M, Factor RE, Nutman T, Armant M, Wahl L, Cuomo P, Trinchieri G: Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. Eur J Immunol 28:3128, 1998
38. Breuninger L, Goonewardene IM, Dempsey WL, Murasko DM: Monocyte culture and adherence modifies LPS-induced IL-6 production and inhibition by hydrocortisone. Clin Immunol Immunopathol 72:264, 1994
39. Fahmi H, Chaby R: Desensitization of macrophages to endotoxin effects is not correlated with a down-regulation of lipopolysaccharide-binding sites. Cell Immunol 150:216, 1993
40. Manthey CL, Perera PY, Salkowski CA, Vogel SN: Taxol provides a second signal for marine macrophage tumoricidal activity. J Immunol 152:825, 1994
41. Ding AH, Porteu F, Sanchez E, Nathan CF: Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science 248:370, 1990
42. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282:2085, 1998
43. Manthey CL, Qureshi N, Stutz PL, Vogel SN: Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages. J Exp Med 178:695, 1993
44. Sutterwala FS, Noel GJ, Clynes R, Mosser DM: Selective suppression of interleukin-12 induction after macrophage receptor ligation. J Exp Med 185:1977, 1997
45. Wittmann M, Zwirner J, Larsson V-A, Kirchhoff K, Begemann G, Kapp A, Götze O, Werfel T: C5a suppresses the production of IL-12 by IFN-γ-primed and lipopolysaccharide-challenged human monocytes. J Immunol 162:6763, 1999