Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance

European Journal of Immunology

Volumn 28, Issue 10, 1998, Pages 3128-3136

  Karp, Christopher L ^a,b,f   Wysocka, Maria ^c   Ma, Xiaojing ^c   Marovich, Mary ^d   Factor, Rachel E ^b   Nutman, Thomas ^d   Armant, Myriam ^d   Wahl, Larry ^e   Cuomo, Peter ^b   Trinchieri, Giorgio ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c WISTAR INSTITUTE   (United States)

^d NATIONAL INSTRUMENTS   (United States)

^e NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Dendritic cell; Endotoxin tolerance; IL 12; Macrophage; Monocyte; Sepsis

Indexed keywords

ENDOTOXIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

CELLS, CULTURED; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MONOCYTES; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 14444267318     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199810)28:10<3128::AID-IMMU3128>3.0.CO;2-T     Document Type: Article

References (36)

1. Fearon, D. T. and Locksley, R. M., The instructive role of innate immunity in the acquired immune response. Science 1996. 272: 50-54.
2. Dinarello, C. A., The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J. Infect. Dis. 1991. 163: 1177-1184.
3. Tracey, K., Fong, Y., Hesse, D., Manogue, K., Lee, A., Kuo, G., Lowry, S. and Cerami, A., Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987. 330: 662-664.
4. Morrison, D. C. and Ryan, J. L., Endotoxins and disease mechanisms. Annu. Rev. Med. 1987. 38: 417-432.
5. Haimovitz-Friedman, A., Gordon-Cardo, C., Bayoumy, S., Garzotto, M., McLoughlin, M., Gallily, R., Edwards III, C. K., Schuchman, E. H., Fuks, Z. and Kolesnick, R., Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med. 1997. 186: 1831-1841.
6. Beeson, P. B., Tolerance to bacterial pyrogens. I. Factors influencing its development. J. Exp. Med. 1947. 86: 29-38.
7. Mengozzi, M. and Ghezzi, P., Cytokine downregulation in endotoxin tolerance. Eur. Cytokine Netw. 1993. 4: 89-98.
8. Munoz, C., Carlet, J., Fitting, C., Misset, B., Bleriot, J. P. and Cavaillon, J. M., Dysregulation of in vitro cytokine production by monocytes during sepsis. J. Clin. Invest. 1991. 88: 1747-1754.
9. Granowitz, E. V., Porat, R., Mier, J. W., Orencole, S. F., Kaplanski, G., Lynch, E. A., Ye, K., Vannier, E., Wolff, S. M. and Dinarello, C. A., Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans. J. Immunol. 1993. 151: 1637-1645.
10. Ertel, W., Kremer, J. P., Kenney, J., Steckholzer, U., Jarrar, D., Trentz, O. and Schildberg, F. W., Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995. 85: 1341-1347.
11. Randow, F., Syrbe, U., Meisel, C., Krausch, D., Zuckermann, H., Platzer, C. and Volk, H.-D., Mechanisms of endotoxin desensitization: Involvement of interleukin 10 and transforming growth factor β. J. Exp. Med. 1995. 181: 1887-1892.
12. van der Poll, T., Coyle, S. M., Moldawer, L. L. and Lowry, S. F., Changes in endotoxin-induced cytokine production by whole blood after in vivo exposure of normal humans to endotoxin. J. Infect Dis. 1996. 174: 1356-1360.
13. Berg, D. J., Kuhn, R., Rajewsky, K., Muller, W., Menon, S., Davidson, N., Grunig, G. and Rennick, D., Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and Schwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 1995. 96: 2339-2347.
14. Volk, H. D., Thieme, M., Ruppe, U., Heym, S., Döcke, W.-D., Manger, D., Zuckermann, S., Golosubow, A., Nieter, B., Klug, H. and van Baehr, R., Alterations in function and phenotype of monocytes from patients with septic disease: predictive value and new therapeutic strategies. In Faist, E. and Meakins, J. L. (Eds.) Host Defense Dysfunction in Trauma, Shock, and Sepsis. Springer, Berlin 1993, pp 246-271.
15. Döcke, W.-D., Syrbe, U., Meinecke, A., Platzer, C., Makki, A., Asadullah, K. A., Klug, C., Zuckermann, H., Reinke, P., Brunner, H., von Baehr, R. and Volk, H. D., Improvement of monocytic function: a new therapeutic approach? In Reinhart, K., Eyrich, K. and Sprung, C. (Eds.) Sepsis: Current Perspectives in Pathophysiology and Therapy. Springer, Berlin 1994, pp 437-500.
16. Döcke, W.-D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K. A., Reinke, P., Volk, H.-D. and Kox, W., Monocyte deactivation in septic patients: Restoration by IFN-γ treatment. Nature Med. 1997. 3: 678-681.
17. Randow, F., Döcke, W.-D., Bundschuh, D. S., Hartung, T., Wendel, A. and Volk, H.-D., In vitro prevention and reversal of lipopolysaccharide desensitization by IFN-γ, IL-12, and granulocyte-macrophage colony-stimulating factor. J. Immunol. 1997. 158: 2911-2918.
18. Bundschuh, D. S., Barsig, J., Hartung, T., Randow, F., Döcke, W.-D., Volk, H.-D. and Wendel, A., Granulocyte-macrophage colony-stimulating factor and IFN-γ restore the systemic TNF-α response to endotoxin in lipopolysaccharide-desensitized mice. J. Immunol. 1997. 158: 2862-2871.
19. Trinchieri, G., Interleukin-12: A cytokine at the interface of inflammation and immunity. Adv. Immunol. 1998. 70, in press.
20. Heinzel, F. P., The role of IFN-γ in the pathology of experimental endotoxemia. J. Immunol. 1990. 145: 2920-2924.
21. Heinzel, F. P., Rerko, R. M., Ling, P., Hakimi, J. and Schoenhaut, D. S., Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect. Immun. 1994. 62: 4244-4249.
22. Wysocka, M., Kubin, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P. and Trinchieri, G., Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 1995. 25: 672-676.
23. Ozmen, L., Pericin, M., Hakimi, J., Chizzonite, R. A., Wysocka, M., Trinchieri, G., Gately, M. and Garotta, G., Interleukin 12, interferon γ, and tumor necrosis factor α, are the key cytokines of the generalized Schwartzman reaction. J. Exp. Med. 1994. 180: 907-915.
24. Mattner, F., Ozmen, L., Podlaski, F. J., Wilkinson, V. L., Presky, D. H., Gately, M. K. and Alber, G., Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect. Immun. 1997. 65: 4734-4737.
25. Zisman, D. A., Kunkel, S. L., Strieter, R. M., Gauldie, J., Tsai, W. C., Bramson, J., Wilkowski, J. M., Bucknell, K. A. and Standiford, T. J., Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis. Shock 1997. 8: 349-356.
26. Brandzaeg, P., Kierulf, P., Gaustad, P., Skulberg, A., Bruun, J. N., Halvorsen, S. and Sorensen, E., Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease. J. Infect. Dis. 1989. 159: 195-204.
27. Karp, C. L., Wysocka, M., Wahl, L. M., Ahearn, J. M., Cuomo, P. J., Sherry, B., Trinchieri, G. and Griffin, D. E., Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996. 273: 228-231.
28. Zuckerman, S. H. and Evans, G. F, Endotoxin tolerance: In vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level. Cell Immunol. 1992. 140: 513-519.
29. Marchant, A., Guetdan, C., Houzet, L, Amraoui, Z., Sels, A., Huez, G., Goldman, M. and Kuys, V., Defective translation of tumor necrosis factor mRNA in lipopolysaccharide-tolerant macrophages. J. Inflamm. 1996. 46: 114-123.
30. Ertel, W., Kremer, J.-P., Steckholzer, U., Jarrar, D., Trentz, O. and Schildberg, F. W., Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 1995. 85: 1341-1347.
31. Sousa, C. R., Heiny, S., Scharton-Kersten, T., Jankovic, D., Charest, H., Germain, R. N. and Sher, A., In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 1997. 186: 1819-1829.
32. Ertel, W., Keel, M., Neidhardt, R., Steckholzaer, U., Kremer, J.-P., Ungethuern, U. and Trentz, O., Inhibition of the defense system stimulating interleukin-12 interferon-γ pathway during critical illness. Blood 1997. 89: 1612-1620.
33. Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S., Pryor, K., Walsh, B. J., Nicholson, R. C., Fairlie, W. D., Por, S. B., Robbins, J. M. and Brent, S. N., MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily. Proc. Natl. Acad. Sci. USA 1997. 94: 11514-11519.
34. Mertz, P. M., DeWitt, D. L., Stetler-Stevenson, W. G. and Wahl, L. M., Interleukin 10 suppression of monocyte prostaglandin H synthase-2: Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production. J. biol. Chem. 1994. 269: 21322-21329.
35. Blauvelt, A., Asada, H., Saville, M. W., Klaus-Kovtun, V., Altman, D. J., Yarchoan, R. and Katz, S. I., Productive infection of dendritic cells by HIV-1 and their ability to capture virus are mediated through separate pathways. J. Clin. Invest. 1997. 100: 2043-2053.
36. Ma, X., Chow, J. M., Gri, G., Carra, G., Gerosa, F., Wolf, S. F., Dzialo, R. and Trinchieri, G., The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 1996. 183: 147-157.