Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

Immunity

Volumn 6, Issue 6, 1997, Pages 673-679

  Taki, Shinsuke ^a   Sato, Takeo ^a   Ogasawara, Kouetsu ^a   Fukuda, Taeko ^a   Sato, Mitsuharu ^a   Hida, Shigeaki ^a   Suzuki, Gen ^b   Mitsuyama, Masao ^c   Shin, Eun Hee ^d   Kojima, Soumei ^d   Taniguchi, Tadatsugu ^a   Asano, Yoshihiro ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; HELPER CELL; IMMUNE RESPONSE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030741433     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80443-4     Document Type: Article

References (56)

1. Abdollahi, A., Lord, K.A., Hoffman-Liebermann, B., and Liebermann, D.A. (1991). Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition. Cell Growth Diff. 2, 401-407.
2. Afonso, L.C., Scharton, T.M., Vieira, L.Q., Wysocka, M., Trinchieri, G., and Scott, P. (1994). The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263, 235-237.
3. Berberich, I., Shu, G.L., and Clark, E.A. (1994). Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B. J. Immunol. 153, 4357-4366.
4. Campbell, K.A., Ovendale, P.J., Kennedy, M.K., Fanslow, W.C., Reed, S.G., and Maliszewski, C.R. (1996). CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 4, 283-290.
5. Chua, A.O., Wilkinson, V.L., Presky, D.H., and Gubler, U. (1995). Cloning and characterization of a mouse IL-12 receptor-β component. J. Immunol. 155, 4286-4294.
6. Coffman, R.L., and Weid, T. (1997). Multiple Pathways for the Initiation of T helper 2 (Th2) Responses. J. Exp. Med. 185, 373-376.
7. Duncan, G.S., Mittrücker, H.-W., Kägi, D., Matsuyama, T., and Mak, T.W. (1996). The transcription factor interferon regulatory-1 is essential for natural killer cell function in vivo. J. Exp. Med. 184, 2043-2048.
8. Durbin, J.E., Hackenmiller, R., Simon, M.C., and Levy, D.E. (1996). Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450.
9. Farrar, M.A., and Schreiber, R.D. (1993). The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11, 571-611.
10. Fearon, D.T., and Locksley, R.M. (1996). The instructive role of innate immunity in the acquired immune response. Science 272, 50-53.
11. Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M.F., Mak, T.W., Horak, I., and Zinkernagel, R.M. (1997). Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J. Exp. Med. 185, 921-932.
12. Flesch, I.E., Hess, J.H., Huang, S., Aguet, M., Rothe, J., Bluethmann, H., and Kaufmann, S.H. (1995). Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181, 1615-1621.
13. Fujita, T., Reis, L.F., Watanabe, N., Kimura, Y., Taniguchi, T., and Vilcek, J. (1989). Induction of the transcription factor IRF-1 and interferon-β mRNAs by cytokines and activators of second-messenger pathways. Proc. Natl. Acad. Sci. USA 86, 9936-9940.
14. Fujiwara, H., Kikutani, H., Suematsu, S., Naka, T., Yoshida, K., Yoshida, K., Tanaka, T., Suemura, M., Matsumoto, N., Kojima, S., et al. (1994). The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc. Natl. Acad. Sci. USA 91, 6835-6839.
15. Güler, M.L., Gorham, J.D., Hsieh, C.S., Mackey, A.J., Steen, R.G., Dietrich, W.F., and Murphy, K.M. (1996). Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development. Science 271, 984-987.
16. + T helper cell phenotype development in aT cell receptor-αβ-transgenic model. J. Exp. Med. 182, 1579-1584.
17. Hou, J., Schindler, U., Henzel, W.J., Ho, T.C., Brasseur, M., and McKnight, S.L. (1994). An interleukin-4-induced transcription factor: IL-4 Stat. Science 265, 1701-1706.
18. Hsieh, C.S., Heimberger, A.B., Gold, J.S., O'Garra, A., and Murphy, K.M. (1992). Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89, 6065-6069.
19. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
20. Hsieh, C.S., Macatonia, S.E., O'Garra, A., and Murphy, K.M. (1995). T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181, 713-721.
21. Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E., Jr., and Murphy, K.M. (1995). Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181, 1755-1762.
22. Kamanaka, M., Yu, P., Yasui, T., Yoshida, K., Kawabe, T., Horii, T., Kishimoto, T., and Kikutani, H. (1996). Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 4, 275-282.
23. Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., Le, J., Koh, S.I., Kimura, T., Green, S.J., et al. (1994). Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263, 1612-1615.
24. Kaplan, M.H., Schindler, U., Smiley, S.T., and Grusby, M.J. (1996a). Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313-319.
25. Kaplan, M.H., Sun, Y.L., Hoey, T., and Grusby, M.J. (1996b). Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177.
26. Kaufman, S.H.E. (1993). Immunity to intracellular bacteria. Annu. Rev. Immunol. 11, 129-163.
27. Kopf, M., Gros, G.L., Bachmann, M., Lamers, M.C., Bluethmann, H., and Köhler, G. (1993). Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362, 245-248.
28. LeGros, G.G., Ben-Sasson, S.S., Seder, R., Finkelman, F.D., and Paul, W.E. (1990). Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929.
29. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5, 1119-1128.
30. Magram, J., Connaughton, S.E., Warrier, R.R., Carvajal, D.M., Wu, C.Y., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D.A., and Gately, M.K. (1996). IL-12-deficient mice are defective in IFN γ production and type 1 cytokine responses. Immunity 4, 471-481.
31. Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T.M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993). Targeted disruption of IRF-1 or IRF-2 results in abnormal type 1 IFN gene induction and aberrant lymphocyte development. Cell 75, 83-97.
32. Matter, F., Mattner, F., Magram, J., Ferrante, J., Launois, P., Padova, K.D., Behin, R., Gately, M.K., Louis, J.A., and Alber, G. (1996). Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26, 1553-1559.
33. Meraz, M.A., White, J.M., Sheehan, K.C., Bach, E.A., Rodig, S.J., Dighe, A.S., Kaplan, D.H., Riley, J.K., Greenlund, A.C., Campbell, D., et al. (1996). Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442.
34. Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., and Taniguchi, T. (1988). Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell 54, 903-913.
35. Mosmann, T.R., and Coffman, R.L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173.
36. Mosmann, T.R., and Sad, S. (1996). The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17, 138-146.
37. Murphy, K.M., Weaver, C.T., Elish, M., Allen, P.M., and Loh, D.Y. (1989). Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism. Proc. Natl. Acad. Sci. USA 86, 10034-10038.
38. Murphy, T.L., Cleveland, M.G., Kulesza, P., Magram, J., and Murphy, K.M. (1995). Regulation of interleukin 12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15, 5258-5267.
39. Neish, A.S., Read, M.A., Thanos, D., Pine, R., Maniatis, T., and Collins, T. (1995). Endothelial interferon regulatory factor 1 cooperates with NF-κB as a transcriptional activator of vascular cell adhesion molecule 1. Mol. Cell. Biol. 15, 2558-2569.
40. Presky, D., Yang, H., Minetti, L., Chua, A., Nabavi, N., Wu, C.-Y., Gately, M., and Gubler, U. (1996). A functional interleukin 12 receptor complex is composed of two-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93, 14002-14007.
41. Scharton-Kersten, T., Afonso, L.C., Wysocka, M., Trinchieri, G., and Scott, P. (1995). IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154, 5320-5330.
42. Scott, P. (1993). IL-12: initiation cytokine for cell-mediated immunity. Science 260, 496-497.
43. Scott, P., and Kaufman, S.H.E. (1991). The role of T-cell subsets and cytokines in the regulation of infection. Immunol. Today 12, 346-348.
44. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A., et al. (1996). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380, 630-633.
45. Swain, S.L., Weinberg, A.D., English, M., and Huston, G. (1990). IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145, 3796-3806.
46. + αβ T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells. J. Immunol. 156, 2436-2442.
47. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., and Akira, S. (1996). Essential role of Stat6 in IL-4 signaling. Nature 380, 627-630.
48. Tamura, T., Ishihara, M., Lamphier, M.S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T.W., Taki, S., and Taniguchi, T. (1995). An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376, 596-599.
49. Tanaka, N., Kawakami, T., and Taniguchi, T. (1993). Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 13, 4531-4538.
50. Thierfelder, W.E., van Deursen, J.M., Yamamoto, K., Tripp, R.A., Sarawar, S.R., Carson, R.T., Sangster, M.Y., Vignali, D.A., Doherty, P.C., Grosveld, G.C., et al. (1996). Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171-174.
51. Tripp, C.S., Wolf, S.F., and Unanue, E.R. (1993). Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90, 3725-3729.
52. Urban, J.F., Jr., Madden, K.B., Cheever, A.W., Trotta, P.P., Katona, I.M., and Finkelman, F.D. (1993). IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis. J. Immunol. 151, 7086-7094.
53. Urban, J.F., Jr., Maliszewski, C.R., Madden, K.B., Katona, I.M., and Finkelman, F.D. (1995). IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice. J. Immunol. 154, 4675-4684.
54. Watanabe, Y., Mitsuyama, M., Sano, M., Nakano, H., and Nomoto, K. (1986). Enhanced resistance against Listeria monocytogenes at an early phase of primary infection in pregnant mice: activation of macrophages during pregnancy. Infect. Immun. 52, 730-735.
55. Wolf, S.F., Temple, P.A., Kobayashi, M., Young, D., Dicig, M., Lowe, L., Dzialo, R., Fitz, L., Ferenz, C., Hewick, R.M., et al. (1991). Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146, 3074-3081.
56. Yoshimoto, T., Kojima, K., Funakoshi, T., Endo, Y., Fujita, T., and Nariuchi, H. (1996). Molecular cloning and characterization of murine IL-12 genes. J. Immunol. 156, 1082-1088.