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Volumn 18, Issue 24, 1999, Pages 6973-6982

Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells

Author keywords

CpG DNA; IL 12; Innate immunity; MAP kinase; TNF

Indexed keywords

DNA; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR;

EID: 0343114462     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.24.6973     Document Type: Article
Times cited : (106)

References (61)
  • 1
    • 0030480268 scopus 로고    scopus 로고
    • The role of IL-12 in the pathogenesis of Th1 cell-mediated autoimmune diseases
    • Adorini, L., Gregori, S., Magram, J. and Trembleau, S. (1996) The role of IL-12 in the pathogenesis of Th1 cell-mediated autoimmune diseases. Ann. NY Acad. Sci., 795, 208-215.
    • (1996) Ann. NY Acad. Sci. , vol.795 , pp. 208-215
    • Adorini, L.1    Gregori, S.2    Magram, J.3    Trembleau, S.4
  • 3
    • 0028135018 scopus 로고
    • IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines
    • Aragane, Y. et al. (1994) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol. 153, 5366-5372.
    • (1994) J. Immunol. , vol.153 , pp. 5366-5372
    • Aragane, Y.1
  • 4
    • 0029554196 scopus 로고
    • Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis and signaling by tumor necrosis factor itself
    • Beutler, B. and Kruys, V. (1995) Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis and signaling by tumor necrosis factor itself. J. Cardiovasc. Pharmacol. Suppl. 2, 25, S1-S8.
    • (1995) J. Cardiovasc. Pharmacol. Suppl. 2 , vol.25
    • Beutler, B.1    Kruys, V.2
  • 5
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures
    • Bhat, N.R., Zhang, P., Lee, J.C. and Hogan, E.L. (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci., 18, 1633-1641.
    • (1998) J. Neurosci. , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 8
    • 0031045622 scopus 로고    scopus 로고
    • Origin, maturation and antigen presenting function of dendritic cells
    • Cella, M., Sallusto, F. and Lanzavecchia, A. (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol., 9, 10-16.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 10-16
    • Cella, M.1    Sallusto, F.2    Lanzavecchia, A.3
  • 9
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley, S., Paterson, H., Kemp, P. and Marshall, C.J. (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell, 77, 841-852.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 10
    • 0026701132 scopus 로고
    • Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
    • D'Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med., 176, 1387-1398.
    • (1992) J. Exp. Med. , vol.176 , pp. 1387-1398
    • D'Andrea, A.1
  • 11
    • 0031718359 scopus 로고    scopus 로고
    • Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family
    • de Groot, R.P., Coffer, P.J. and Koenderman, L. (1998) Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell Signal., 10, 619-628.
    • (1998) Cell Signal. , vol.10 , pp. 619-628
    • De Groot, R.P.1    Coffer, P.J.2    Koenderman, L.3
  • 13
    • 0025936177 scopus 로고
    • A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP. Are translated from the same mRNA
    • Descombes, P. and Schibler, U. (1991) A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP. are translated from the same mRNA. Cell, 67, 569-579.
    • (1991) Cell , vol.67 , pp. 569-579
    • Descombes, P.1    Schibler, U.2
  • 15
    • 0029836383 scopus 로고    scopus 로고
    • 2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan
    • 2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan. J. Infect. Dis., 174, 777-785.
    • (1996) J. Infect. Dis. , vol.174 , pp. 777-785
    • Dziarski, R.1    Jin, Y.P.2    Gupta, D.3
  • 16
    • 14444279192 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of mitogen-activated protein kinase kinase
    • Favata, M.F. et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem., 273, 18623-18632.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18623-18632
    • Favata, M.F.1
  • 17
    • 0030831201 scopus 로고    scopus 로고
    • Seeking wisdom in innate immunity
    • Fearon, D.T. (1997) Seeking wisdom in innate immunity. Nature, 388, 323-324.
    • (1997) Nature , vol.388 , pp. 323-324
    • Fearon, D.T.1
  • 18
    • 0025808629 scopus 로고
    • Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor
    • Gubler, U. et al. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl Acad. Sci. USA, 88, 4143-4147.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 4143-4147
    • Gubler, U.1
  • 19
    • 0033390212 scopus 로고    scopus 로고
    • Signal transduction pathways activated by CpG-DNA
    • Häcker, H. (1999) Signal transduction pathways activated by CpG-DNA. Curr. Top. Microbiol. Immunol., 247, 77-92.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.247 , pp. 77-92
    • Häcker, H.1
  • 20
    • 0032476602 scopus 로고    scopus 로고
    • CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
    • Häcker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G.B. and Wagner, H. (1998) CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J., 17, 6230-6240.
    • (1998) EMBO J. , vol.17 , pp. 6230-6240
    • Häcker, H.1    Mischak, H.2    Miethke, T.3    Liptay, S.4    Schmid, R.5    Sparwasser, T.6    Heeg, K.7    Lipford, G.B.8    Wagner, H.9
  • 21
    • 0030768744 scopus 로고    scopus 로고
    • CSF-1 signal transduction
    • Hamilton, J.A. (1997) CSF-1 signal transduction. J. Leukoc. Biol., 62, 145-155.
    • (1997) J. Leukoc. Biol. , vol.62 , pp. 145-155
    • Hamilton, J.A.1
  • 23
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
    • Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. and Steinman, R.M. (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med., 176, 1693-1702.
    • (1992) J. Exp. Med. , vol.176 , pp. 1693-1702
    • Inaba, K.1    Inaba, M.2    Romani, N.3    Aya, H.4    Deguchi, M.5    Ikehara, S.6    Muramatsu, S.7    Steinman, R.M.8
  • 24
    • 0030728946 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade
    • Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kolch, W. and Hammerschmidt, W. (1997) Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J., 16, 6478-6485.
    • (1997) EMBO J. , vol.16 , pp. 6478-6485
    • Kieser, A.1    Kilger, E.2    Gires, O.3    Ueffing, M.4    Kolch, W.5    Hammerschmidt, W.6
  • 25
    • 0029831666 scopus 로고    scopus 로고
    • High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
    • Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N. and Schuler, G. (1996) High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Mecl., 184, 741-746.
    • (1996) J. Exp. Mecl. , vol.184 , pp. 741-746
    • Koch, F.1    Stanzl, U.2    Jennewein, P.3    Janke, K.4    Heufler, C.5    Kampgen, E.6    Romani, N.7    Schuler, G.8
  • 29
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford, G.B., Bauer, M., Blank, C., Reiter, R., Wagner, H. and Heeg, K. (1997a) CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol., 27, 2340-2344.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 30
    • 0031460777 scopus 로고    scopus 로고
    • Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
    • Lipford, G.B., Sparwasser, T., Bauer, M., Zimmermann, S., Koch, E.S., Heeg, K. and Wagner, H. (1997b) Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol., 27, 3420-3426.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3420-3426
    • Lipford, G.B.1    Sparwasser, T.2    Bauer, M.3    Zimmermann, S.4    Koch, E.S.5    Heeg, K.6    Wagner, H.7
  • 31
    • 0033118982 scopus 로고    scopus 로고
    • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
    • Lu, H.T., Yang, D.D., Wysk, M., Gatti, E., Mellman, I., Davis, R.J. and Flavell, R.A. (1999) Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J., 18, 1845-1857.
    • (1999) EMBO J. , vol.18 , pp. 1845-1857
    • Lu, H.T.1    Yang, D.D.2    Wysk, M.3    Gatti, E.4    Mellman, I.5    Davis, R.J.6    Flavell, R.A.7
  • 32
    • 0023649835 scopus 로고
    • CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
    • Luckow, B. and Schutz, G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res., 15, 5490.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 5490
    • Luckow, B.1    Schutz, G.2
  • 33
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M.B., Kukutsch, N., Ogilvie, A.L., Rossner, S., Koch, F., Romani, N. and Schuler, G. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods, 223, 77-92.
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rossner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 36
    • 0029143632 scopus 로고
    • Regulation of interleukin 12 p40 expression through an NF-κ B half-site
    • Murphy, T.L., Cleveland, M.G., Kulesza, P., Magram, J. and Murphy, K.M. (1995) Regulation of interleukin 12 p40 expression through an NF-κ B half-site. Mol. Cell. Biol., 15, 5258-5267.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5258-5267
    • Murphy, T.L.1    Cleveland, M.G.2    Kulesza, P.3    Magram, J.4    Murphy, K.M.5
  • 37
    • 0030018413 scopus 로고    scopus 로고
    • Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor
    • Neumann, B., Luz, A., Pfeffer, K. and Holzmann, B. (1996) Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med., 184, 259-264.
    • (1996) J. Exp. Med. , vol.184 , pp. 259-264
    • Neumann, B.1    Luz, A.2    Pfeffer, K.3    Holzmann, B.4
  • 38
    • 0027297663 scopus 로고
    • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    • Pfeffer, K. et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell, 73, 457-467.
    • (1993) Cell , vol.73 , pp. 457-467
    • Pfeffer, K.1
  • 39
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky, D.S. (1996) Immune activation by bacterial DNA: a new genetic code. Immunity, 5, 303-310.
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 40
    • 0030872393 scopus 로고    scopus 로고
    • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
    • Plevy, S.E., Gemberling, J.H., Hsu, S., Dorner, A.J. and Smale, S.T. (1997) Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol., 17, 4572-4588.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4572-4588
    • Plevy, S.E.1    Gemberling, J.H.2    Hsu, S.3    Dorner, A.J.4    Smale, S.T.5
  • 41
    • 0029090620 scopus 로고
    • Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor α
    • Prichett, W., Hand, A., Sheilds, J. and Dunnington, D. (1995) Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor α. J. Inflamm., 45, 97-105.
    • (1995) J. Inflamm. , vol.45 , pp. 97-105
    • Prichett, W.1    Hand, A.2    Sheilds, J.3    Dunnington, D.4
  • 42
    • 0031964902 scopus 로고    scopus 로고
    • Relative contribution of transcription and translation to the induction of tumor necrosis factor-α by lipopolysaccharide
    • Raabe, T., Bukrinsky, M. and Currie, R.A. (1998) Relative contribution of transcription and translation to the induction of tumor necrosis factor-α by lipopolysaccharide. J. Biol. Chem., 273, 974-980.
    • (1998) J. Biol. Chem. , vol.273 , pp. 974-980
    • Raabe, T.1    Bukrinsky, M.2    Currie, R.A.3
  • 43
    • 0031775746 scopus 로고    scopus 로고
    • Dendritic cell survival and maturation are regulated by different signaling pathways
    • Rescigno, M., Martino, M., Sutherland, C.L., Gold, M.R. and Ricciardi-Castagnoli, P. (1998) Dendritic cell survival and maturation are regulated by different signaling pathways. J. Exp. Med., 188, 2175-2180.
    • (1998) J. Exp. Med. , vol.188 , pp. 2175-2180
    • Rescigno, M.1    Martino, M.2    Sutherland, C.L.3    Gold, M.R.4    Ricciardi-Castagnoli, P.5
  • 44
    • 0029935860 scopus 로고    scopus 로고
    • Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages
    • Sanghera, J.S., Weinslein, S.L., Aluwalia, M., Girn, J. and Pelech, S.L. (1996) Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages. J. Immunol., 156, 4457-4465.
    • (1996) J. Immunol. , vol.156 , pp. 4457-4465
    • Sanghera, J.S.1    Weinslein, S.L.2    Aluwalia, M.3    Girn, J.4    Pelech, S.L.5
  • 46
    • 0032030339 scopus 로고    scopus 로고
    • FLT3: Receptor and ligand. Biology and potential clinical application
    • Shurin, M.R., Esche, C. and Lotze, M.T. (1998) FLT3: receptor and ligand. Biology and potential clinical application. Cytokine Growth Factor Rev., 9, 37-48.
    • (1998) Cytokine Growth Factor Rev. , vol.9 , pp. 37-48
    • Shurin, M.R.1    Esche, C.2    Lotze, M.T.3
  • 47
    • 0030844212 scopus 로고    scopus 로고
    • T-cell-independent granuloma formation in response to Mycobacterium avium: Role of tumour necrosis factor-α and interferon-γ
    • Smith, D., Hansch, H., Bancroft, G. and Ehlers, S. (1997) T-cell-independent granuloma formation in response to Mycobacterium avium: role of tumour necrosis factor-α and interferon-γ. Immunology, 92, 413-421.
    • (1997) Immunology , vol.92 , pp. 413-421
    • Smith, D.1    Hansch, H.2    Bancroft, G.3    Ehlers, S.4
  • 48
    • 0000060327 scopus 로고    scopus 로고
    • In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
    • Sousa, C.R., Hieny, S., Scharton-Kersten, T., Jankovic, D., Charest, H., Germain, R.N. and Sher, A. (1997) In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med., 186, 1819-1829.
    • (1997) J. Exp. Med. , vol.186 , pp. 1819-1829
    • Sousa, C.R.1    Hieny, S.2    Scharton-Kersten, T.3    Jankovic, D.4    Charest, H.5    Germain, R.N.6    Sher, A.7
  • 50
    • 0030816325 scopus 로고    scopus 로고
    • Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-α-mediated shock
    • Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Hacker, H., Heeg, K. and Wagner, H. (1997b) Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol., 27, 1671-1679.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1671-1679
    • Sparwasser, T.1    Miethke, T.2    Lipford, G.3    Erdmann, A.4    Hacker, H.5    Heeg, K.6    Wagner, H.7
  • 51
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser, T., Koch, E.S., Vabulas, R.M., Heeg, K., Lipford, G.B., Ellwart, J.W. and Wagner, H. (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol., 28, 2045-2054.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6    Wagner, H.7
  • 52
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activated by bacterial DNA
    • Stacey, K.J., Sweet, M.J. and Hume, D.A. (1996) Macrophages ingest and are activated by bacterial DNA. J. Immunol., 157, 2116-2122.
    • (1996) J. Immunol. , vol.157 , pp. 2116-2122
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 53
    • 0025299347 scopus 로고
    • The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model
    • Sved, J. and Bird, A. (1990) The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. Proc. Natl Acad. Sci. USA, 87, 4692-4696.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 4692-4696
    • Sved, J.1    Bird, A.2
  • 55
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization and antitumor activity
    • Tokunaga, T. et al. (1984) Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization and antitumor activity. J. Natl Cancer Inst., 72, 955-962.
    • (1984) J. Natl Cancer Inst. , vol.72 , pp. 955-962
    • Tokunaga, T.1
  • 56
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: A cytokine at the interface of inflammation and immunity
    • Trinchieri, G. (1998) Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol., 70, 83-243.
    • (1998) Adv. Immunol. , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 57
    • 0032995849 scopus 로고    scopus 로고
    • Bacterial CpG-DNA activates immune cells to signal 'infectious danger'
    • Wagner, H. (1999) Bacterial CpG-DNA activates immune cells to signal 'infectious danger'. Adv. Immunol., 73, 329-368.
    • (1999) Adv. Immunol. , vol.73 , pp. 329-368
    • Wagner, H.1
  • 59
    • 0025875022 scopus 로고
    • Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
    • Wolf, S.F. et al. (1991) Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol., 146, 3074-3081.
    • (1991) J. Immunol. , vol.146 , pp. 3074-3081
    • Wolf, S.F.1
  • 60
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
    • Yamamoto, S., Yamamoto, T., Kataoka, T., Kuramoto, E., Yano, O. and Tokunaga, T. (1992) Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol., 148, 4072-4076.
    • (1992) J. Immunol. , vol.148 , pp. 4072-4076
    • Yamamoto, S.1    Yamamoto, T.2    Kataoka, T.3    Kuramoto, E.4    Yano, O.5    Tokunaga, T.6
  • 61
    • 0032209664 scopus 로고    scopus 로고
    • Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
    • Yi, A.K. and Krieg, A.M. (1998) Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA. J. Immunol., 161, 4493-4497.
    • (1998) J. Immunol. , vol.161 , pp. 4493-4497
    • Yi, A.K.1    Krieg, A.M.2


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