Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-κB downregulation in transcriptional repression of the p40 gene

Journal of Clinical Investigation

Volumn 101, Issue 1, 1998, Pages 252-262

  D'Ambrosio, Daniele ^a   Cippitelli, Marco ^b   Cocciolo, Maria Gabriella ^a   Mazzeo, Daniela ^a   Di Lucia, Pietro ^a   Lang, Rosmarie ^a   Sinigaglia, Francesco ^a   Panina Bordignon, Paola ^a  

^a ROCHE MILANO RICERCHE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Antiinflammatory drug; Autoimmunity; NF B; T helper; VDR

Indexed keywords

CALCITRIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION REGULATION;

EID: 0031974910     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1050     Document Type: Article

References (65)

1. Hsieh, C.S., S.E. Macatonia, C.S. Tripp, S.F. Wolf, A. O'Garra, and K.M. Murphy. 1993. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:547-549.
2. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
3. Manetti, R., P. Parronchi, M.G. Giudizi, M.P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
4. Scott, P. 1993. IL-12: Initiation cytokine for cell-mediated immunity. Science. 260:496-497.
5. Kobayashi, M., L. Fitz, M. Ryan, R.M. Hewick, S.C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827-845.
6. Stern, A.S., F.J. Podlaski, J.D. Hulmes, Y.C. Pan, P.M. Quinn, A.G. Wolitzky, P.C. Familletti, D.L. Stremlo, T. Truitt, R. Chizzonite, and M.K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA. 87:6808-6812.
7. D'Andrea, A., M. Rengaraju, J. Valiante, J. Chehimi, M. Kubin, M. Aste, S.H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387-1398.
8. Wolf, S.D., D. Seithburth, B. Perussia, J. Yetz-Adalpe, A. D'Andrea, and G. Trinchieri. 1992. Cell sources of natural killer cell stimulatory factor (NKSF/ IL-12) transcripts and subunit expression. Fed. Am. Soc. Exp. Biol. (FASEB) J. 6:1335.
9. Gubler, U., A.O. Chua, D.S. Schoenhaut, C.M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A.G. Wolitzky, P.M. Quinn, P.C. Familletti, et al. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA. 88:4143-4147.
10. Cella, M., D. Scheidegger, K. Palmer-Lehman, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on human dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747-752.
11. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kämpgen, N. Romani, and G. Schuler. 1996. High level of IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741-746.
12. Ma, X., J.M. Chow, G. Gri, G. Carra, F. Gerosa, S.F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147-157.
13. Ma, X., M. Neurath, G. Gri, and G. Trinchieri. 1997. Identification and characterization of a novel ets-2-related nuclear complex implicated in the activation of the human IL-12 p40 gene promoter. J. Biol. Chem. 272:10389-10395.
14. Murphy, T.L., M.G. Cleveland, P. Kuleszka, J. Magram, and K.M. Murphy. 1995. Regulation of interleukin-12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258-5267.
15. Tone, Y., S.A. Thompson, J.M. Babik, K.F. Nolan, M. Tone, C. Raven, and H. Waldmann. 1996. Structure and chromosomal location of mouse interleukin-12 p35 and p40 subunit genes. Eur. J. Immunol. 26:1222-1227.
16. Yoshimoto, T., K. Kojima, T. Funakoshi, Y. Endo, T. Fujita, and H. Nariuchi. 1996. Molecular cloning and characterization of murine IL-12 genes. J. Immunol. 156:1082-1088.
17. Trembleau, S., T. Germann, M.K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmmune diseases. Immunol. Today. 16:383-386.
18. 3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl. Acad. Sci. USA. 93:7861-7864.
19. 3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J. Clin. Invest. 87:1103-1107.
20. 3 on the induction of experimental autoimmune thyroiditis. Clin. Immunol. Immunopathol. 54:53-63.
21. 3. Clin. Exp. Immunol. 94:412-417.
22. 3 attenuates the expression of experimental murine lupus of MRL/1 mice. Autoimmunity. 12:143-148.
23. 3 prevents insulitis in NOD mice. Diabetes. 41:1491-1495.
24. Panina-Bordignon, P., D. Mazzeo, P. Di Lucia, D. D'Ambrosio, R. Lang, L. Fabbri, C. Self, and F. Sinigaglia. 1997. β2-Agonists prevent Th1 development by selective inhibition of interleukin 12. J. Clin. Invest. 100:1513-1519.
25. 3. J. Steroid Biochem. Mol. Biol. 53:599-602.
26. De Luca, H.F., and H.K. Schnoes. 1983. Vitamin D: recent advances. Annu. Rev. Biochem. 52:411-439.
27. Bouillon, R., W.H. Okamura, and A.W. Norman. 1995. Structure-function relationships in the vitamin D endocrine system. Endoc. Rev. 16:200-256.
28. 3. Proc. Natl. Acad. Sci. USA. 80:5907-5911.
29. 3 induces normal mononuclear blood cells to differentiate in the direction of monocyte-macrophage. Haematologia. 23:9.
30. 3. Blood. 76:2457.
31. 3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages. Blood. 82:1300-1307.
32. 3 inhibits antigen-induced T cell activation. J. Immunol. 133:1748-1754.
33. 3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Cell. Immunol. 98:311-322.
34. 3 J. Clin. Invest. 79:1659-1664.
35. Baker, A.R., D.P. McDonnell, M. Hughes, T.M. Crisp, D.J. Mangelsdorf, M.R. Haussler, J.W. Pike, J. Shine, and B.W. O'Malley. 1988. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. USA. 85:3294-3298.
36. 3: a steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms. J. Steroid Biochem. 30:33-39.
37. Beato, M. 1989. Gene regulation by steroid hormones. Cell. 56:335-344.
38. Carlberg, C., I. Bendik, A. Wyss, E. Meier, L.J. Sturzenbecker, J.F. Grippo, and W. Hunziker. 1993. Two nuclear signaling pathways for vitamin D. Nature. 361:657-660.
39. Schräder, M., K.M. Müller, and C. Carlberg. 1994. Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D responsive elements by thyroid hormone. J. Biol. Chem. 269:5501-5504.
40. 3 signaling. Nature. 355:446-449.
41. Schräder, M., I. Bendik, M. Becker-André, and C. Carlberg. 1993. Interaction between retinoic acid and vitamin D signaling pathways. J. Biol. Chem. 268:17830-17836.
42. Nishikawa, J., M. Kitaura, M. Matsumoto, M. Imagawa, and T. Nishihara. 1994. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer. Nucleic Acids Res. 22:2902-2907.
43. 3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol. Cell. Biol. 15:5789-5799.
44. 3. Proc. Natl. Acad. Sci. USA. 92:10990-10994.
45. Lane, P., C. Burdet, F. McConnell, A. Lanzavecchia, and E. Padovan. 1995. CD40L-independent B cell activation revealed by CD40L-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation. Eur. J. Immunol. 25:1788-1793.
46. Recalde, H.R. 1984. A simple method of obtaining monocytes in suspension. J. Immunol. Methods. 69:71-77.
47. Romani, N., D. Reider, M. Heuer, S. Ebner, E. Kampgen, B. Eibl, D. Niederwieser, and G. Schuler. 1996. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol. Methods. 196:137-151.
48. Zhang, M., M.K. Gately, E. Wang, J. Gong, S.F. Wolf, S. Lu, R.L. Modlin, and P.F. Barnes. 1994. Interleukin-12 at the site of disease in tuberculosis. J. Clin. Invest. 93:1733-1739.
49. de Wet, J.R., K.V. Wood, M. De Luca, D.R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
50. Dellabona, P., F. Latron, A. Maffei, L. Scarpellino, and R.S. Accolla. 1989. Transcriptional control of MHC class II gene expression during differentiation from B cells to plasma cells. J. Immunol. 142:2902-2910.
51. Dignam, J.D., R.M. Lebowitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
52. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
53. Macatonia, S., N.A. Hosken, M. Litton, P. Vieira, C.-S. Hsieh, I.A. Culpepper, M. Wysocka, G. Trinchieri, K.M. Murphy, and A. O'Garra. 1995. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154:5071-5079.
54. 3 inhibits γ-interferon synthesis by normal human peripheral blood. Proc. Natl. Acad. Sci. USA. 84:3385-3389.
55. 3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol. Cell. Biol. 14:3329-3338.
56. 3. Mol. Endocrinol. 9:1814-1824.
57. Lohoff, M., D. Ferrick, H.W. Mittrucker, G.S. Duncan, S. Bischof, M. Rollinghoff, and T.W. Mak. 1997. Interferon regulatory factor-1 is required for Th1 immune response in vivo. Immunity. 6:681-689.
58. Taki, S., T. Sato, K. Ogasawara, T. Fukuda, M. Sato, S. Hida, G. Suzuki, M. Mitsuyama, E. Shin, S. Kojima et al. 1997. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity. 6:673-679.
59. Reis, L.F., H. Harada, J.D. Wolchok, T. Taniguchi, and J. Vilcek. 1992. Critical role of a common transcription factor. IRF-1, in the regulation of IFN-β and IFN-inducible genes. EMBO J. 13:4798-4806.
60. 3. Blood. 76:189-197.
61. Ten, R., C. Paya, N. Israel, O. Le Bail, M. Mattei, J.L. Virelizier, P. Kourilsky, and A. Israel. 1992. The characterization of the promoter of the gene encoding the p50 subunit of NF-κB indicates that it participates in its own regulation. EMBO J. 11:195-203.
62. Auphan, N., J. Di Donato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science. 270:286-290.
63. Scheinman, R., P. Cogswell, A. Lofquist, and A. Baldwin. 1995. Role of transcriptional activation of IκB alpha in mediation of immunosuppression of glucocorticoids. Science. 270:283-285.
64. 3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J. Clin. Endocrinol. Metab. 64:1.
65. 3 by interferon-gamma stimulated normal human bone marrow and alveolar macrophages. J. Biol. Chem. 262:10931.