IL-4 is a mediator of IL-12p70 induction by human Th2 cells: Reversal of polarized Th2 phenotype by dendritic cells

Journal of Immunology

Volumn 165, Issue 4, 2000, Pages 1877-1881

  Kalinski, P ^a   Smits, H H ^a   Schuitemaker, J H N ^a   Vieira, P L ^a   Van Eijk, M ^a   De Jong, E C ^a   Wierenga, E A ^a   Kapsenberg, M L ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 39; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ANTIGEN PRESENTING CELL; ARTICLE; ATOPIC DERMATITIS; AUTOIMMUNITY; B LYMPHOCYTE; CELL POLARITY; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; INFECTION; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; TUMOR IMMUNITY;

EID: 0034663999     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.4.1877     Document Type: Article

References (27)

1. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
2. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype
3. T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching
4. In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation
5. A role for B cells in the development of T cell helper function in a malaria infection in mice
6. + T cells, analyzed at the single-cell level
7. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL- 13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor α production
8. Interleukin-12 production by dendritic cells: The role of CD40-CD40L interactions in Th1 T-cell responses
9. Regulation of bioactive IL-12 production in li-popolysaccharide- stimulated human monocytes is determined by the expression of the p35 subunit
10. Lack of IL-12 Signaling in human allergen-specific Th2 cells
11. Final maturation of dendritic cells is associated with impaired responsiveness to IFN γ and to bacterial IL-12 inducers: Decreased ability of mature DC to produce IL-12 during the interaction with T helper cells
12. + T cells
13. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
14. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: Comparison with IL-4 and modulation by IFN-γ or IL-10
15. Human Th2-like cell clones induce IL-12 production by dendritic cells and may express several cytokine profiles
16. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice
17. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
18. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells
19. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ
20. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis
21. Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells
22. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
23. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4
24. + T helper type 1 cell responses to Candida albicans
25. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
26. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
27. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-γ production by dendritic cells