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Volumn 163, Issue 12, 1999, Pages 6403-6412

Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; LIPOPHOSPHOGLYCAN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; SYNAPTOPHYSIN;

EID: 0032740614     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (297)

References (55)
  • 1
    • 0025191159 scopus 로고
    • Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
    • Green, S. J., M. S. Meltzer, J. B. Hibbs, and C. A. Nacy. 1990. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J. Immunol. 144:278.
    • (1990) J. Immunol. , vol.144 , pp. 278
    • Green, S.J.1    Meltzer, M.S.2    Hibbs, J.B.3    Nacy, C.A.4
  • 2
    • 0026062981 scopus 로고
    • Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages
    • Liew, F. Y., D. Moss, C. Parkinson, M. V. Rogers, and S. Moncada. 1991. Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur. J. Immunol. 21:3009.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 3009
    • Liew, F.Y.1    Moss, D.2    Parkinson, C.3    Rogers, M.V.4    Moncada, S.5
  • 6
    • 0028936417 scopus 로고
    • Effects of nitric oxide synthase inhibitors on murine infection with mycobacterium-tuberculosis
    • Chan, J., K. Tanaka, D. Carroll, J. Flynn, and B. R. Bloom. 1995. Effects of nitric oxide synthase inhibitors on murine infection with mycobacterium-tuberculosis. Infect. Immunity : 63:736.
    • (1995) Infect. Immunity , vol.63 , pp. 736
    • Chan, J.1    Tanaka, K.2    Carroll, D.3    Flynn, J.4    Bloom, B.R.5
  • 7
    • 0028092958 scopus 로고
    • Nitric oxide synthases: Roles, tolls, and controls
    • Nathan, C., and Q. Xie. 1994. Nitric oxide synthases: roles, tolls, and controls. Cell 78:915.
    • (1994) Cell , vol.78 , pp. 915
    • Nathan, C.1    Xie, Q.2
  • 8
    • 0029769511 scopus 로고    scopus 로고
    • Regulation of expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages
    • Proudfoot, L., A. Nikolaev, G. J. Feng, X. Q. Wei, M. A. J. Ferguson, J. S. Brimacombe, and F. Y. Liew. 1996. Regulation of expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc. Natl. Acad. Sci. USA 93:10984.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10984
    • Proudfoot, L.1    Nikolaev, A.2    Feng, G.J.3    Wei, X.Q.4    Ferguson, M.A.J.5    Brimacombe, J.S.6    Liew, F.Y.7
  • 10
    • 0028970060 scopus 로고
    • Interleukin-12 - A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. 1995. Interleukin-12 - a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251
    • Trinchieri, G.1
  • 13
    • 0028106830 scopus 로고
    • Role of interferon regulatory factor 1 in induction of nitric oxide synthase
    • Martin, E., C. Nathan, and Q. W. Xie. 1994. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:977.
    • (1994) J. Exp. Med. , vol.180 , pp. 977
    • Martin, E.1    Nathan, C.2    Xie, Q.W.3
  • 14
    • 0027939931 scopus 로고
    • Role of transcription factor NFκB/Rel in induction of nitric oxide synthase
    • Xie, Q. W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NFκB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4705
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 17
    • 0030891006 scopus 로고    scopus 로고
    • Identification and characterization of a novel Ets-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter
    • Ma, X. J., M. Neurath, G. Gri, and G. Trinchieri. 1997. Identification and characterization of a novel Ets-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J. Biol. Chem. 272:10389.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10389
    • Ma, X.J.1    Neurath, M.2    Gri, G.3    Trinchieri, G.4
  • 18
    • 0030872393 scopus 로고    scopus 로고
    • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and rel proteins
    • Plevy, S. E., J. H. M. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4572
    • Plevy, S.E.1    Gemberling, J.H.M.2    S, H.3    Dorner, A.J.4    Smale, S.T.5
  • 19
    • 0029912242 scopus 로고    scopus 로고
    • Inhibitions of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NFκB
    • Griscavage, J. M., S. Wilk, and L. J. Ignarro. 1996. Inhibitions of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NFκB. Proc. Natl. Acad. Sci. USA 93:3308.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3308
    • Griscavage, J.M.1    Wilk, S.2    Ignarro, L.J.3
  • 20
    • 0030664056 scopus 로고    scopus 로고
    • Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin12 p40 induction
    • Scharton-Kersten, T., C. Contursi, A. Masumi, A. Sher, and K. Ozato. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin12 p40 induction. J. Exp. Med. 186:1523.
    • (1997) J. Exp. Med. , vol.186 , pp. 1523
    • Scharton-Kersten, T.1    Contursi, C.2    Masumi, A.3    Sher, A.4    Ozato, K.5
  • 22
    • 0026530288 scopus 로고
    • Lipopolysaccharide-and interferon-γ-induced expression hck and lyn tyrosine kinases in murine bone marrow-derived macrophages
    • Boulet, I., S. Ralph, E. Stanley, P. Lock, A. R. Dunn, S. P. Green, and W. A. Philips. 1992. Lipopolysaccharide-and interferon-γ-induced expression hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogene 7:703.
    • (1992) Oncogene , vol.7 , pp. 703
    • Boulet, I.1    Ralph, S.2    Stanley, E.3    Lock, P.4    Dunn, A.R.5    Green, S.P.6    Philips, W.A.7
  • 23
    • 0027434028 scopus 로고
    • Lipopolysaccharide induces activation on CD14-associated protein tyrosine kinase p53/56lyn
    • Stefanova, I., M. L. Corcorna, E. M. Horak, L. M. Wahl, J. B. Bolen, and I. D. Horak. 1993. Lipopolysaccharide induces activation on CD14-associated protein tyrosine kinase p53/56lyn. J. Biol. Chem. 268:20725.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20725
    • Stefanova, I.1    Corcorna, M.L.2    Horak, E.M.3    Wahl, L.M.4    Bolen, J.B.5    Horak, I.D.6
  • 26
    • 0026712854 scopus 로고
    • Nitric oxide synthase regulatory site phosphorylation by cyclic AMP-dependent protein kinase C, and calcium calmodulin protein kinase identification of flavin and calmodulin binding sites
    • Bredt, D. S., C. D. Feris, and S. H. Snyder. 1992. Nitric oxide synthase regulatory site phosphorylation by cyclic AMP-dependent protein kinase C, and calcium calmodulin protein kinase identification of flavin and calmodulin binding sites. J. Biol. Chem. 267:10976.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10976
    • Bredt, D.S.1    Feris, C.D.2    Snyder, S.H.3
  • 27
    • 0028129888 scopus 로고
    • CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide
    • Liu, M. K., P. Herrera-Velit, R. W. Nrownsey, and N. E. Reiner. 1994. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153:2642.
    • (1994) J. Immunol. , vol.153 , pp. 2642
    • Liu, M.K.1    Herrera-Velit, P.2    Nrownsey, R.W.3    Reiner, N.E.4
  • 28
    • 0028535921 scopus 로고
    • Lipopolysaccharide signals activation of tumor-necrosis factor biosynthesis through the Ras/Raf-1/MEK/MAPK pathway
    • Geppert, T. D., C. E. Whitehurst, P. Thompson, and B. Beutler. 1994. Lipopolysaccharide signals activation of tumor-necrosis factor biosynthesis through the Ras/Raf-1/MEK/MAPK pathway. Mol. Med. 1:93.
    • (1994) Mol. Med. , vol.1 , pp. 93
    • Geppert, T.D.1    Whitehurst, C.E.2    Thompson, P.3    Beutler, B.4
  • 29
    • 0029054963 scopus 로고
    • Activation of Raf-1 and mitogen-activated protein-kinase in murine macrophages partially mimics lipopolysaccharide-induced signalling events
    • Hambleton, J., M. McMahon, and A. L. Defranco. 1995. Activation of Raf-1 and mitogen-activated protein-kinase in murine macrophages partially mimics lipopolysaccharide-induced signalling events. J. Exp. Med. 182:147.
    • (1995) J. Exp. Med. , vol.182 , pp. 147
    • Hambleton, J.1    McMahon, M.2    Defranco, A.L.3
  • 30
    • 0026659881 scopus 로고
    • Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein-kinases in macrophages
    • Weinstein, S. L., J. S. Sanghera, K. Lemke, A. L. Defranco, and S. L. Pelech. 1992. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein-kinases in macrophages. J. Biol. Chem. 267: 14955.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14955
    • Weinstein, S.L.1    Sanghera, J.S.2    Lemke, K.3    Defranco, A.L.4    Pelech, S.L.5
  • 31
    • 0029967151 scopus 로고    scopus 로고
    • Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide
    • Nick, J. A., N. J. Avdi, P. Gerwins, G. L. Johnson, and S. Worthen. 1996. Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J. Immunol. 156:4867.
    • (1996) J. Immunol. , vol.156 , pp. 4867
    • Nick, J.A.1    Avdi, N.J.2    Gerwins, P.3    Johnson, G.L.4    Worthen, S.5
  • 32
    • 0031035322 scopus 로고    scopus 로고
    • Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms
    • Guthridge, C. J., D. Eidlen, W. P. Arend, A. Gutierrez Hartmann, and M. F. Smith. 1997. Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms. Mol. Cell. Biol. 17:1118.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1118
    • Guthridge, C.J.1    Eidlen, D.2    Arend, W.P.3    Hartmann, A.G.4    Smith, M.F.5
  • 33
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signalregulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures
    • Bhat, N. R., P. S. Zhang, J. C. Lee, and E. L. Hogan. 1998. Extracellular signalregulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neuroscience 18:1633.
    • (1998) J. Neuroscience , vol.18 , pp. 1633
    • Bhat, N.R.1    Zhang, P.S.2    J C, L.3    Hogan, E.L.4
  • 34
    • 0026778409 scopus 로고
    • Signal transduction from cell-surface to nucleus in development and disease
    • Karin, M. 1992. Signal transduction from cell-surface to nucleus in development and disease. FASEB J. 6:2581.
    • (1992) FASEB J. , vol.6 , pp. 2581
    • Karin, M.1
  • 36
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb, M. H., and E. J. Goldsmith. 1995. How MAP kinases are regulated. J. Biol. Chem. 270:14843.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14843
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 37
    • 0027429621 scopus 로고
    • Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation
    • Her, J. H., S. Lakhani, K. Zu, J. Vila, P. Dent, T. W. Styrgill, and M. J. Weber. 1993. Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation. Biochem. J. 296:25.
    • (1993) Biochem. J. , vol.296 , pp. 25
    • Her, J.H.1    Lakhani, S.2    Zu, K.3    Vila, J.4    Dent, P.5    Styrgill, T.W.6    Weber, M.J.7
  • 38
    • 0028125887 scopus 로고
    • Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PACI
    • Ward, Y., S. Gupta, P. Jensen, M. Wartmann, R. J. Davis, and K. Kelly. 1994. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PACI. Nature 367:651.
    • (1994) Nature , vol.367 , pp. 651
    • Ward, Y.1    Gupta, S.2    Jensen, P.3    Wartmann, M.4    Davis, R.J.5    Kelly, K.6
  • 39
    • 0030866897 scopus 로고    scopus 로고
    • Activation mechanism of the MAP kinase Erk2 by dual phosphorylation
    • Canagarajah, B. J., A. Khokhlatchev, M. H. Cobb, and E. J. Goldsmith. 1997. Activation mechanism of the MAP kinase Erk2 by dual phosphorylation. Cell 90:859.
    • (1997) Cell , vol.90 , pp. 859
    • Canagarajah, B.J.1    Khokhlatchev, A.2    Cobb, M.H.3    Goldsmith, E.J.4
  • 40
    • 0029034774 scopus 로고
    • Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
    • Pang, L., T. Sawada, S. J. Decker, and A. R. Saltiel. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270:13585.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13585
    • Pang, L.1    Sawada, T.2    Decker, S.J.3    Saltiel, A.R.4
  • 41
    • 0028988138 scopus 로고
    • SB203580 is a specific inhibitor of a MAP kinase homolog which is stimulated by cellular stresses and interleukin-1
    • Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, and J. C. Lee. 1995. SB203580 is a specific inhibitor of a MAP kinase homolog which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:229.
    • (1995) FEBS Lett. , vol.364 , pp. 229
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6    Young, P.R.7    Lee, J.C.8
  • 42
    • 0029021946 scopus 로고
    • The chemical synthesis of Leishmania donovani phosphoglycan via polycondensation of a glycobiosyl hydrogenphosphonate monomer
    • Nikolaev, A. V., J. A. Chudek, and M. A. J. Ferguson. 1995. The chemical synthesis of Leishmania donovani phosphoglycan via polycondensation of a glycobiosyl hydrogenphosphonate monomer. Carbohydr. Res. 272:179.
    • (1995) Carbohydr. Res. , vol.272 , pp. 179
    • Nikolaev, A.V.1    Chudek, J.A.2    Ferguson, M.A.J.3
  • 44
    • 0023895357 scopus 로고
    • A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-messenger RNA splicing
    • Lee, K. A. W., A. Bindereif, and M. R. Green. 1988. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-messenger RNA splicing. Gene Anal. Techn. 5:22.
    • (1988) Gene Anal. Techn. , vol.5 , pp. 22
    • Lee, K.A.W.1    Bindereif, A.2    Green, M.R.3
  • 45
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding-proteins with mini-extracts, prepared from a small number of cells
    • Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding-proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res. 17:6419.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 46
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrew, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 2499
    • Andrew, N.C.1    Faller, D.V.2
  • 47
    • 0030977398 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-α and release of arachidonic acid in mast cells: Indications of communication between p38 and p42 MAP kinases
    • Zhang, C., R. A. Baumgartner, K. Yamada, and M. A. Beaven. 1997. Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-α and release of arachidonic acid in mast cells: indications of communication between p38 and p42 MAP kinases. J. Biol. Chem. 272:13397.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13397
    • Zhang, C.1    Baumgartner, R.A.2    Yamada, K.3    Beaven, M.A.4
  • 48
    • 0028139174 scopus 로고
    • The role of interleukin-12 in the immune-responses, disease and therapy
    • Trinchieri, G., and P. Scott. 1994. The role of interleukin-12 in the immune-responses, disease and therapy. Immunol. Today 15:460.
    • (1994) Immunol. Today , vol.15 , pp. 460
    • Trinchieri, G.1    Scott, P.2
  • 49
    • 0031985903 scopus 로고    scopus 로고
    • Regulation of morocyte IL-10 synthesis by endogenous IL-1 and TNF-α: Role of the p38 and p42/44 mitogen-activated protein kinases
    • Foey, A. D., S. L. Parry, L. M. Williams, M. Feldmann, B. M. J. Foxwell, and F. M. Brennan. 1998. Regulation of morocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J. Immunol. 160:920.
    • (1998) J. Immunol. , vol.160 , pp. 920
    • Foey, A.D.1    Parry, S.L.2    Williams, L.M.3    Feldmann, M.4    Foxwell, B.M.J.5    Brennan, F.M.6
  • 50
    • 0030997409 scopus 로고    scopus 로고
    • Activation of stall and subsequent transcription of inducible nitric oxide synthase gene in c6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21(ras)
    • Nishiya, T., T. Uehara, H. Edamatsu, Y. Kaziro, H. Itoh, and Y. Nomura. 1997. Activation of Stall and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21(ras). FEBS Lett. 408:33.
    • (1997) FEBS Lett. , vol.408 , pp. 33
    • Nishiya, T.1    Uehara, T.2    Edamatsu, H.3    Kaziro, Y.4    Itoh, H.5    Nomura, Y.6
  • 51
    • 0032510838 scopus 로고    scopus 로고
    • Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases
    • Larsen, C. M., K. A. W. Wadt, L. F. Juhl, H. U. Andersen, A. E. Karlsen, M. S. S. Su, K. Seedorf, L. Shapiro, C. A. Dinarello, and T. Mandrup Poulsen. 1998. Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J. Biol. Chem. 273:15294.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15294
    • Larsen, C.M.1    Wadt, K.A.W.2    Juhl, L.F.3    Andersen, H.U.4    Karlsen, A.E.5    Su, M.S.S.6    Seedorf, K.7    Shapiro, L.8    Dinarello, C.A.9    Poulsen, T.M.10
  • 52
    • 0030712362 scopus 로고    scopus 로고
    • Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes
    • DaSilva, J., B. Pierrat, J. L. Mary, and W. Lesslauer. 1997. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272:28373.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28373
    • Dasilva, J.1    Pierrat, B.2    Mary, J.L.3    Lesslauer, W.4
  • 53
    • 0031803059 scopus 로고    scopus 로고
    • SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes
    • Badger, A. M., M. N. Cook, M. W. Lark, T. M. NewmanTarr, B. A. Swift, A. H. Nelson, F. C. Barone, and S. Kumar. 1998. SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes. J. Immunol. 161:467.
    • (1998) J. Immunol. , vol.161 , pp. 467
    • Badger, A.M.1    Cook, M.N.2    Lark, M.W.3    Newmantarr, T.M.4    Swift, B.A.5    Nelson, A.H.6    Barone, F.C.7    Kumar, S.8
  • 54
    • 0030951146 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E(2) biosynthesis stimulated by interleukin-1β
    • Guan, Z. H., L. D. Baier, and A. R. Morrison. 1997. p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E(2) biosynthesis stimulated by interleukin-1β. J. Biol. Chem. 272:8083.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8083
    • Guan, Z.H.1    Baier, L.D.2    Morrison, A.R.3
  • 55
    • 0032513227 scopus 로고    scopus 로고
    • Synergistic regulation of the human interleukin-12 p40 promoter by NFκB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages
    • Gri, G., D. Savio, G. Trinchieri, and X. J. Ma. 1998. Synergistic regulation of the human interleukin-12 p40 promoter by NFκB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages. J. Biol. Chem. 273:6431.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6431
    • Gri, G.1    Savio, D.2    Trinchieri, G.3    Ma, X.J.4


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